|
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|
| Mar 02 • 19:00 | Philadelphia Union |  | - |  | Toronto FC | 1 | : | 3 |
| Mar 02 • 20:30 | Orlando City SC |  | - |  | New York City FC | 2 | : | 2 |
| Mar 02 • 22:30 | Columbus Crew |  | - |  | New York Red Bulls | 1 | : | 1 |
| Mar 02 • 22:30 | FC Dallas |  | - |  | New England Revolution | 1 | : | 1 |
| Mar 03 • 00:00 | Houston Dynamo |  | - |  | Real Salt Lake | 1 | : | 1 |
| Mar 03 • 00:00 | Colorado Rapids |  | - |  | Portland Timbers | 3 | : | 3 |
| Mar 03 • 00:00 | Vancouver Whitecaps |  | - |  | Minnesota United | 2 | : | 3 |
| Mar 03 • 02:00 | Los Angeles Galaxy |  | - |  | Chicago Fire | 2 | : | 1 |
| Mar 03 • 04:00 | Seattle Sounders |  | - |  | FC Cincinnati | 4 | : | 1 |
| Mar 03 • 04:00 | San Jose Earthquakes |  | - |  | Montreal Impact | 1 | : | 2 |
| Mar 04 • 00:00 | Washington DC United |  | - |  | Atlanta United | 2 | : | 0 |
| Mar 04 • 02:30 | Los Angeles FC |  | - |  | Sporting Kansas City | 2 | : | 1 |
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|
|
| Mar 09 • 19:00 | Chicago Fire | | - | | Orlando City SC | 1 | : | 1 |
| Mar 09 • 20:00 | New England Revolution | | - | | Columbus Crew | 0 | : | 2 |
| Mar 09 • 21:30 | FC Dallas | | - | | Los Angeles Galaxy | 2 | : | 0 |
| Mar 09 • 23:00 | Houston Dynamo | | - | | Montreal Impact | 2 | : | 1 |
| Mar 10 • 00:00 | Real Salt Lake | | - | | Vancouver Whitecaps | 1 | : | 0 |
| Mar 10 • 02:00 | San Jose Earthquakes | | - | | Minnesota United | 0 | : | 3 |
| Mar 10 • 04:00 | Seattle Sounders | | - | | Colorado Rapids | 2 | : | 0 |
| Mar 10 • 20:00 | Sporting Kansas City | | - | | Philadelphia Union | 2 | : | 0 |
| Mar 10 • 20:00 | New York City FC | | - | | Washington DC United | 0 | : | 0 |
| Mar 10 • 22:00 | Atlanta United | | - | | FC Cincinnati | 1 | : | 1 |
| Mar 11 • 00:30 | Los Angeles FC | | - | | Portland Timbers | 4 | : | 1 |
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| Mar 16 • 18:00 | Chicago Fire | | - | | Seattle Sounders | 2 | : | 4 |
| Mar 16 • 19:00 | Columbus Crew | | - | | FC Dallas | 1 | : | 0 |
| Mar 16 • 20:00 | Houston Dynamo | | - | | Vancouver Whitecaps | 3 | : | 2 |
| Mar 16 • 20:30 | New York Red Bulls | | - | | San Jose Earthquakes | 4 | : | 1 |
| Mar 16 • 21:00 | Orlando City SC | | - | | Montreal Impact | 1 | : | 3 |
| Mar 17 • 01:00 | Washington DC United | | - | | Real Salt Lake | 5 | : | 0 |
| Mar 17 • 03:30 | Los Angeles Galaxy | | - | | Minnesota United | 3 | : | 2 |
| Mar 17 • 20:00 | New York City FC | | - | | Los Angeles FC | 2 | : | 2 |
| Mar 17 • 22:00 | FC Cincinnati | | - | | Portland Timbers | 3 | : | 0 |
| Mar 18 • 00:00 | Atlanta United | | - | | Philadelphia Union | 1 | : | 1 |
| Mar 18 • 00:30 | Toronto FC | | - | | New England Revolution | 3 | : | 2 |
| Mar 18 • 02:00 | Colorado Rapids | | - | | Sporting Kansas City | 1 | : | 1 |
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|
| Mar 23 • 22:55 | FC Dallas | | - | | Colorado Rapids | 2 | : | 1 |
| Mar 24 • 00:30 | Philadelphia Union | | - | | Columbus Crew | 3 | : | 0 |
| Mar 24 • 00:30 | New York Red Bulls | | - | | Orlando City SC | 0 | : | 1 |
| Mar 24 • 03:30 | Los Angeles FC | | - | | Real Salt Lake | 2 | : | 1 |
| Mar 24 • 21:00 | New England Revolution | | - | | FC Cincinnati | 0 | : | 2 |
| Mar 30 • 01:00 | Toronto FC | | - | | New York City FC | 4 | : | 0 |
| Mar 30 • 18:00 | Chicago Fire | | - | | New York Red Bulls | 1 | : | 0 |
| Mar 30 • 19:00 | New England Revolution | | - | | Minnesota United | 2 | : | 1 |
| Mar 30 • 20:00 | Sporting Kansas City | | - | | Montreal Impact | 7 | : | 1 |
| Mar 30 • 20:30 | San Jose Earthquakes | | - | | Los Angeles FC | 0 | : | 5 |
| Mar 31 • 00:30 | FC Cincinnati | | - | | Philadelphia Union | 0 | : | 2 |
| Mar 31 • 00:30 | Columbus Crew | | - | | Atlanta United | 2 | : | 0 |
| Mar 31 • 03:00 | Colorado Rapids | | - | | Houston Dynamo | 1 | : | 4 |
| Mar 31 • 03:00 | Real Salt Lake | | - | | FC Dallas | 2 | : | 4 |
| Mar 31 • 04:00 | Vancouver Whitecaps | | - | | Seattle Sounders | 0 | : | 0 |
| Apr 01 • 00:30 | Orlando City SC | | - | | Washington DC United | 1 | : | 2 |
| Apr 01 • 03:00 | Los Angeles Galaxy | | - | | Portland Timbers | 2 | : | 1 |
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| Apr 06 • 04:00 | Vancouver Whitecaps | | - | | Los Angeles Galaxy | 0 | : | 2 |
| Apr 06 • 19:00 | New York City FC | | - | | Montreal Impact | 0 | : | 0 |
| Apr 06 • 21:00 | Washington DC United | | - | | Los Angeles FC | 0 | : | 4 |
| Apr 06 • 21:00 | Toronto FC | | - | | Chicago Fire | 2 | : | 2 |
| Apr 07 • 01:00 | New York Red Bulls | | - | | Minnesota United | 1 | : | 2 |
| Apr 07 • 01:30 | Orlando City SC | | - | | Colorado Rapids | 4 | : | 3 |
| Apr 07 • 01:30 | Philadelphia Union | | - | | FC Dallas | 2 | : | 1 |
| Apr 07 • 01:30 | Columbus Crew | | - | | New England Revolution | 1 | : | 0 |
| Apr 07 • 02:00 | San Jose Earthquakes | | - | | Portland Timbers | 3 | : | 0 |
| Apr 07 • 04:00 | Seattle Sounders | | - | | Real Salt Lake | 1 | : | 0 |
| Apr 07 • 21:00 | FC Cincinnati | | - | | Sporting Kansas City | 1 | : | 1 |
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|
|
| Apr 10 • 02:00 | Washington DC United | | - | | Montreal Impact | 0 | : | 0 |
| Apr 13 • 02:30 | Chicago Fire | | - | | Vancouver Whitecaps | 1 | : | 1 |
| Apr 13 • 19:00 | Montreal Impact | | - | | Columbus Crew | 1 | : | 0 |
| Apr 13 • 21:00 | Houston Dynamo | | - | | San Jose Earthquakes | 2 | : | 1 |
| Apr 13 • 22:00 | Seattle Sounders | | - | | Toronto FC | 3 | : | 2 |
| Apr 13 • 23:00 | Minnesota United | | - | | New York City FC | 3 | : | 3 |
| Apr 14 • 01:30 | New England Revolution | | - | | Atlanta United | 0 | : | 2 |
| Apr 14 • 02:00 | FC Dallas | | - | | Portland Timbers | 2 | : | 1 |
| Apr 14 • 03:00 | Real Salt Lake | | - | | Orlando City SC | 2 | : | 1 |
| Apr 14 • 03:00 | Colorado Rapids | | - | | Washington DC United | 2 | : | 3 |
| Apr 14 • 04:30 | Los Angeles Galaxy | | - | | Philadelphia Union | 2 | : | 0 |
| Apr 14 • 04:30 | Los Angeles FC | | - | | FC Cincinnati | 2 | : | 0 |
| Apr 15 • 01:00 | Sporting Kansas City | | - | | New York Red Bulls | 2 | : | 2 |
|
|
|
| Apr 18 • 04:00 | Vancouver Whitecaps | | - | | Los Angeles FC | 1 | : | 0 |
| Apr 20 • 01:30 | FC Cincinnati | | - | | Real Salt Lake | 0 | : | 3 |
| Apr 20 • 02:00 | Toronto FC | | - | | Minnesota United | 4 | : | 3 |
| Apr 20 • 05:00 | Los Angeles Galaxy | | - | | Houston Dynamo | 2 | : | 1 |
| Apr 20 • 19:00 | Chicago Fire | | - | | Colorado Rapids | 4 | : | 1 |
| Apr 20 • 19:00 | Philadelphia Union | | - | | Montreal Impact | 3 | : | 0 |
| Apr 20 • 21:00 | Orlando City SC | | - | | Vancouver Whitecaps | 1 | : | 0 |
| Apr 20 • 22:00 | Atlanta United | | - | | FC Dallas | 1 | : | 2 |
| Apr 21 • 01:30 | Columbus Crew | | - | | Portland Timbers | 1 | : | 3 |
| Apr 21 • 01:30 | New England Revolution | | - | | New York Red Bulls | 1 | : | 0 |
| Apr 21 • 04:00 | San Jose Earthquakes | | - | | Sporting Kansas City | 4 | : | 1 |
| Apr 21 • 22:00 | Washington DC United | | - | | New York City FC | 0 | : | 2 |
| Apr 22 • 01:00 | Los Angeles FC | | - | | Seattle Sounders | 4 | : | 1 |
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| Apr 25 • 01:00 | New York City FC | | - | | Chicago Fire | 1 | : | 0 |
| Apr 25 • 01:30 | Columbus Crew | | - | | Washington DC United | 0 | : | 1 |
| Apr 25 • 01:30 | New England Revolution | | - | | Montreal Impact | 0 | : | 3 |
| Apr 25 • 02:00 | Minnesota United | | - | | Los Angeles Galaxy | 0 | : | 0 |
| Apr 25 • 04:30 | Seattle Sounders | | - | | San Jose Earthquakes | 2 | : | 2 |
| Apr 27 • 19:00 | New York City FC | | - | | Orlando City SC | 1 | : | 1 |
| Apr 27 • 21:00 | Toronto FC | | - | | Portland Timbers | 1 | : | 2 |
| Apr 27 • 21:30 | FC Dallas | | - | | San Jose Earthquakes | 0 | : | 0 |
| Apr 27 • 23:00 | Vancouver Whitecaps | | - | | Philadelphia Union | 1 | : | 1 |
| Apr 28 • 00:00 | Atlanta United | | - | | Colorado Rapids | 1 | : | 0 |
| Apr 28 • 01:00 | New York Red Bulls | | - | | FC Cincinnati | 1 | : | 0 |
| Apr 28 • 02:30 | Houston Dynamo | | - | | Columbus Crew | 2 | : | 0 |
| Apr 28 • 02:30 | Sporting Kansas City | | - | | New England Revolution | 4 | : | 4 |
| Apr 28 • 18:30 | Montreal Impact | | - | | Chicago Fire | 1 | : | 0 |
| Apr 28 • 19:30 | Minnesota United | | - | | Washington DC United | 1 | : | 0 |
| Apr 28 • 21:30 | Seattle Sounders | | - | | Los Angeles FC | 1 | : | 1 |
| Apr 29 • 02:00 | Los Angeles Galaxy | | - | | Real Salt Lake | 2 | : | 1 |
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|
|
| May 02 • 01:30 | Philadelphia Union | | - | | FC Cincinnati | 2 | : | 0 |
| May 04 • 03:00 | Colorado Rapids | | - | | Vancouver Whitecaps | 2 | : | 3 |
| May 04 • 20:00 | New York Red Bulls | | - | | Los Angeles Galaxy | 3 | : | 2 |
| May 04 • 22:00 | Houston Dynamo | | - | | FC Dallas | 2 | : | 1 |
| May 04 • 22:00 | Orlando City SC | | - | | Toronto FC | 0 | : | 2 |
| May 04 • 23:00 | Montreal Impact | | - | | New York City FC | 0 | : | 2 |
| May 05 • 01:30 | Philadelphia Union | | - | | New England Revolution | 6 | : | 1 |
| May 05 • 02:00 | Washington DC United | | - | | Columbus Crew | 3 | : | 1 |
| May 05 • 02:00 | Minnesota United | | - | | Seattle Sounders | 1 | : | 1 |
| May 05 • 03:00 | Real Salt Lake | | - | | Portland Timbers | 1 | : | 2 |
| May 05 • 04:00 | San Jose Earthquakes | | - | | FC Cincinnati | 1 | : | 0 |
| May 05 • 04:30 | Los Angeles FC | | - | | Chicago Fire | 0 | : | 0 |
| May 06 • 03:00 | Sporting Kansas City | | - | | Atlanta United | 0 | : | 3 |
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|
|
| May 09 • 01:00 | Atlanta United | | - | | Toronto FC | 2 | : | 0 |
| May 09 • 01:30 | Columbus Crew | | - | | Los Angeles Galaxy | 3 | : | 1 |
| May 09 • 02:00 | Chicago Fire | | - | | New England Revolution | 5 | : | 0 |
| May 09 • 02:00 | New York Red Bulls | | - | | Montreal Impact | 1 | : | 2 |
| May 11 • 04:00 | Vancouver Whitecaps | | - | | Portland Timbers | 1 | : | 0 |
| May 11 • 19:00 | FC Cincinnati | | - | | Montreal Impact | 2 | : | 1 |
| May 11 • 20:00 | FC Dallas | | - | | New York Red Bulls | 1 | : | 3 |
| May 11 • 21:00 | Toronto FC | | - | | Philadelphia Union | 1 | : | 2 |
| May 11 • 22:00 | Los Angeles Galaxy | | - | | New York City FC | 0 | : | 2 |
| May 12 • 01:30 | Columbus Crew | | - | | Los Angeles FC | 0 | : | 3 |
| May 12 • 01:30 | New England Revolution | | - | | San Jose Earthquakes | 3 | : | 1 |
| May 12 • 02:00 | Chicago Fire | | - | | Minnesota United | 2 | : | 0 |
| May 12 • 03:00 | Colorado Rapids | | - | | Real Salt Lake | 2 | : | 3 |
| May 12 • 04:00 | Seattle Sounders | | - | | Houston Dynamo | 1 | : | 0 |
| May 12 • 20:30 | Atlanta United | | - | | Orlando City SC | 1 | : | 0 |
| May 13 • 01:00 | Washington DC United | | - | | Sporting Kansas City | 1 | : | 0 |
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| May 16 • 02:00 | Toronto FC | | - | | Washington DC United | 0 | : | 0 |
| May 16 • 02:30 | Houston Dynamo | | - | | Portland Timbers | 1 | : | 1 |
| May 16 • 04:00 | Vancouver Whitecaps | | - | | Atlanta United | 0 | : | 1 |
| May 16 • 04:30 | Seattle Sounders | | - | | Orlando City SC | 2 | : | 1 |
| May 17 • 04:00 | Los Angeles FC | | - | | FC Dallas | 2 | : | 0 |
| May 18 • 19:00 | Montreal Impact | | - | | New England Revolution | 0 | : | 0 |
| May 18 • 21:00 | Real Salt Lake | | - | | Toronto FC | 3 | : | 0 |
| May 18 • 21:30 | San Jose Earthquakes | | - | | Chicago Fire | 4 | : | 1 |
| May 19 • 01:30 | Philadelphia Union | | - | | Seattle Sounders | 0 | : | 0 |
| May 19 • 02:00 | Minnesota United | | - | | Columbus Crew | 1 | : | 0 |
| May 19 • 02:30 | Sporting Kansas City | | - | | Vancouver Whitecaps | 1 | : | 1 |
| May 19 • 02:30 | Houston Dynamo | | - | | Washington DC United | 2 | : | 1 |
| May 19 • 21:00 | Orlando City SC | | - | | FC Cincinnati | 5 | : | 1 |
| May 19 • 23:00 | New York Red Bulls | | - | | Atlanta United | 1 | : | 0 |
| May 20 • 01:30 | FC Dallas | | - | | Los Angeles FC | 1 | : | 1 |
| May 20 • 02:00 | Los Angeles Galaxy | | - | | Colorado Rapids | 0 | : | 1 |
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|
|
| May 23 • 02:00 | New York Red Bulls | | - | | Vancouver Whitecaps | 2 | : | 2 |
| May 25 • 01:00 | Orlando City SC | | - | | Los Angeles Galaxy | 0 | : | 1 |
| May 25 • 03:00 | Real Salt Lake | | - | | Atlanta United | 2 | : | 1 |
| May 25 • 04:30 | Los Angeles FC | | - | | Montreal Impact | 4 | : | 2 |
| May 25 • 21:30 | Chicago Fire | | - | | New York City FC | 1 | : | 1 |
| May 26 • 01:00 | Vancouver Whitecaps | | - | | FC Dallas | 2 | : | 1 |
| May 26 • 01:30 | New England Revolution | | - | | Washington DC United | 1 | : | 1 |
| May 26 • 01:30 | Philadelphia Union | | - | | Portland Timbers | 1 | : | 3 |
| May 26 • 01:30 | FC Cincinnati | | - | | New York Red Bulls | 0 | : | 2 |
| May 26 • 02:00 | Minnesota United | | - | | Houston Dynamo | 1 | : | 0 |
| May 26 • 03:00 | Colorado Rapids | | - | | Columbus Crew | 3 | : | 2 |
| May 27 • 00:00 | Sporting Kansas City | | - | | Seattle Sounders | 3 | : | 2 |
| May 27 • 01:30 | Toronto FC | | - | | San Jose Earthquakes | 1 | : | 2 |
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| May 30 • 01:00 | Atlanta United | | - | | Minnesota United | 3 | : | 0 |
| May 30 • 01:30 | Montreal Impact | | - | | Real Salt Lake | 2 | : | 1 |
| May 30 • 01:30 | Philadelphia Union | | - | | Colorado Rapids | 1 | : | 1 |
| May 30 • 02:00 | Washington DC United | | - | | Chicago Fire | 3 | : | 3 |
| May 30 • 02:30 | Sporting Kansas City | | - | | Los Angeles Galaxy | 0 | : | 2 |
| Jun 01 • 04:00 | Vancouver Whitecaps | | - | | Toronto FC | 1 | : | 1 |
| Jun 01 • 23:00 | Montreal Impact | | - | | Orlando City SC | 0 | : | 3 |
| Jun 02 • 00:00 | Atlanta United | | - | | Chicago Fire | 2 | : | 0 |
| Jun 02 • 01:00 | New York Red Bulls | | - | | Real Salt Lake | 4 | : | 0 |
| Jun 02 • 01:30 | Columbus Crew | | - | | New York City FC | 2 | : | 2 |
| Jun 02 • 02:00 | FC Dallas | | - | | Seattle Sounders | 2 | : | 1 |
| Jun 02 • 02:00 | Washington DC United | | - | | San Jose Earthquakes | 1 | : | 1 |
| Jun 02 • 02:30 | Houston Dynamo | | - | | Sporting Kansas City | 1 | : | 1 |
| Jun 02 • 02:30 | Colorado Rapids | | - | | FC Cincinnati | 3 | : | 1 |
| Jun 02 • 04:30 | Portland Timbers | | - | | Los Angeles FC | 2 | : | 3 |
| Jun 02 • 22:00 | Minnesota United | | - | | Philadelphia Union | 2 | : | 3 |
| Jun 03 • 04:30 | Los Angeles Galaxy | | - | | New England Revolution | 1 | : | 2 |
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| Jun 06 • 01:30 | Montreal Impact | | - | | Seattle Sounders | 2 | : | 1 |
| Jun 07 • 01:00 | New York City FC | | - | | FC Cincinnati | 5 | : | 2 |
| Jun 08 • 01:00 | Toronto FC | | - | | Sporting Kansas City | 2 | : | 2 |
| Jun 08 • 21:30 | San Jose Earthquakes | | - | | FC Dallas | 2 | : | 2 |
| Jun 09 • 01:30 | Philadelphia Union | | - | | New York Red Bulls | 3 | : | 2 |
| Jun 09 • 03:00 | Colorado Rapids | | - | | Minnesota United | 1 | : | 0 |
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|
|
| Jun 23 • 01:30 | FC Cincinnati | | - | | Los Angeles Galaxy | 0 | : | 2 |
| Jun 23 • 02:00 | FC Dallas | | - | | Toronto FC | 3 | : | 0 |
| Jun 23 • 02:00 | Chicago Fire | | - | | Real Salt Lake | 1 | : | 1 |
| Jun 23 • 04:00 | Vancouver Whitecaps | | - | | Colorado Rapids | 2 | : | 2 |
| Jun 23 • 05:00 | Portland Timbers | | - | | Houston Dynamo | 4 | : | 0 |
| Jun 23 • 23:30 | Columbus Crew | | - | | Sporting Kansas City | 0 | : | 1 |
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| Jun 27 • 01:00 | New England Revolution | | - | | Philadelphia Union | 1 | : | 1 |
| Jun 27 • 01:30 | Montreal Impact | | - | | Portland Timbers | 2 | : | 1 |
| Jun 27 • 02:00 | Washington DC United | | - | | Orlando City SC | 1 | : | 0 |
| Jun 27 • 02:00 | Toronto FC | | - | | Atlanta United | 3 | : | 2 |
| Jun 27 • 03:00 | FC Dallas | | - | | Vancouver Whitecaps | 2 | : | 2 |
| Jun 27 • 04:30 | San Jose Earthquakes | | - | | Houston Dynamo | 2 | : | 0 |
| Jun 29 • 02:00 | New York Red Bulls | | - | | Chicago Fire | 3 | : | 1 |
| Jun 29 • 04:00 | Colorado Rapids | | - | | Los Angeles FC | 1 | : | 0 |
| Jun 29 • 22:00 | Minnesota United | | - | | FC Cincinnati | 7 | : | 1 |
| Jun 30 • 00:00 | Atlanta United | | - | | Montreal Impact | 2 | : | 1 |
| Jun 30 • 01:00 | New York City FC | | - | | Philadelphia Union | 4 | : | 2 |
| Jun 30 • 01:30 | Columbus Crew | | - | | Orlando City SC | 0 | : | 2 |
| Jun 30 • 01:30 | New England Revolution | | - | | Houston Dynamo | 2 | : | 1 |
| Jun 30 • 02:00 | Washington DC United | | - | | Toronto FC | 1 | : | 1 |
| Jun 30 • 04:00 | Seattle Sounders | | - | | Vancouver Whitecaps | 1 | : | 0 |
| Jun 30 • 04:00 | San Jose Earthquakes | | - | | Los Angeles Galaxy | 3 | : | 0 |
| Jun 30 • 04:00 | Real Salt Lake | | - | | Sporting Kansas City | 2 | : | 0 |
| Jul 01 • 05:00 | Portland Timbers | | - | | FC Dallas | 1 | : | 0 |
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|
|
| Jul 04 • 01:00 | New York City FC | | - | | Seattle Sounders | 3 | : | 0 |
| Jul 04 • 01:30 | Orlando City SC | | - | | Philadelphia Union | 1 | : | 3 |
| Jul 04 • 02:00 | Chicago Fire | | - | | Atlanta United | 5 | : | 1 |
| Jul 04 • 02:00 | Minnesota United | | - | | San Jose Earthquakes | 3 | : | 1 |
| Jul 04 • 02:30 | Sporting Kansas City | | - | | Los Angeles FC | 1 | : | 5 |
| Jul 04 • 03:00 | Houston Dynamo | | - | | New York Red Bulls | 4 | : | 0 |
| Jul 04 • 04:00 | Real Salt Lake | | - | | Columbus Crew | 1 | : | 0 |
| Jul 05 • 03:00 | Colorado Rapids | | - | | New England Revolution | 1 | : | 2 |
| Jul 05 • 03:00 | FC Dallas | | - | | Washington DC United | 2 | : | 0 |
| Jul 05 • 04:30 | Los Angeles Galaxy | | - | | Toronto FC | 2 | : | 0 |
| Jul 07 • 01:30 | FC Cincinnati | | - | | Houston Dynamo | 3 | : | 2 |
| Jul 07 • 01:30 | Columbus Crew | | - | | Seattle Sounders | 1 | : | 2 |
| Jul 07 • 01:30 | Montreal Impact | | - | | Minnesota United | 2 | : | 3 |
| Jul 07 • 02:30 | Sporting Kansas City | | - | | Chicago Fire | 1 | : | 0 |
| Jul 07 • 04:30 | San Jose Earthquakes | | - | | Real Salt Lake | 1 | : | 0 |
| Jul 07 • 04:30 | Los Angeles FC | | - | | Vancouver Whitecaps | 6 | : | 1 |
| Jul 07 • 20:00 | Atlanta United | | - | | New York Red Bulls | 3 | : | 3 |
| Jul 07 • 22:30 | Philadelphia Union | | - | | Orlando City SC | 2 | : | 2 |
| Jul 08 • 00:30 | New York City FC | | - | | Portland Timbers | 0 | : | 1 |
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|
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| Jul 13 • 01:00 | Washington DC United | | - | | New England Revolution | 2 | : | 2 |
| Jul 13 • 03:00 | Houston Dynamo | | - | | Los Angeles FC | 1 | : | 3 |
| Jul 13 • 05:00 | Los Angeles Galaxy | | - | | San Jose Earthquakes | 1 | : | 3 |
| Jul 14 • 01:30 | Montreal Impact | | - | | Toronto FC | 0 | : | 2 |
| Jul 14 • 01:30 | Orlando City SC | | - | | Columbus Crew | 1 | : | 0 |
| Jul 14 • 02:00 | Chicago Fire | | - | | FC Cincinnati | 1 | : | 2 |
| Jul 14 • 02:00 | Minnesota United | | - | | FC Dallas | 1 | : | 0 |
| Jul 14 • 04:00 | Real Salt Lake | | - | | Philadelphia Union | 4 | : | 0 |
| Jul 14 • 04:00 | Vancouver Whitecaps | | - | | Sporting Kansas City | 0 | : | 3 |
| Jul 14 • 05:00 | Portland Timbers | | - | | Colorado Rapids | 2 | : | 2 |
| Jul 14 • 21:55 | Seattle Sounders | | - | | Atlanta United | 2 | : | 1 |
| Jul 15 • 00:30 | New York Red Bulls | | - | | New York City FC | 2 | : | 1 |
|
|
|
| Jul 18 • 01:00 | Atlanta United | | - | | Houston Dynamo | 5 | : | 0 |
| Jul 18 • 01:00 | New England Revolution | | - | | Vancouver Whitecaps | 4 | : | 0 |
| Jul 18 • 02:00 | Toronto FC | | - | | New York Red Bulls | 3 | : | 1 |
| Jul 18 • 02:00 | Chicago Fire | | - | | Columbus Crew | 2 | : | 2 |
| Jul 19 • 02:00 | FC Cincinnati | | - | | Washington DC United | 1 | : | 4 |
| Jul 19 • 04:00 | Portland Timbers | | - | | Orlando City SC | 1 | : | 1 |
| Jul 20 • 04:00 | Los Angeles Galaxy | | - | | Los Angeles FC | 3 | : | 2 |
| Jul 21 • 01:30 | Columbus Crew | | - | | Montreal Impact | 2 | : | 1 |
| Jul 21 • 01:30 | Philadelphia Union | | - | | Chicago Fire | 2 | : | 0 |
| Jul 21 • 01:30 | Toronto FC | | - | | Houston Dynamo | 1 | : | 3 |
| Jul 21 • 02:30 | Sporting Kansas City | | - | | FC Dallas | 0 | : | 2 |
| Jul 21 • 03:00 | Colorado Rapids | | - | | New York City FC | 1 | : | 2 |
| Jul 21 • 04:00 | Real Salt Lake | | - | | Minnesota United | 1 | : | 1 |
| Jul 21 • 04:00 | Vancouver Whitecaps | | - | | San Jose Earthquakes | 1 | : | 3 |
| Jul 21 • 22:00 | Atlanta United | | - | | Washington DC United | 2 | : | 0 |
| Jul 22 • 00:00 | FC Cincinnati | | - | | New England Revolution | 0 | : | 2 |
| Jul 22 • 01:30 | Orlando City SC | | - | | New York Red Bulls | 0 | : | 1 |
| Jul 22 • 03:30 | Seattle Sounders | | - | | Portland Timbers | 1 | : | 2 |
|
|
|
| Jul 27 • 01:30 | New York City FC | | - | | Sporting Kansas City | 3 | : | 1 |
| Jul 27 • 04:00 | Los Angeles FC | | - | | Atlanta United | 4 | : | 3 |
| Jul 28 • 01:00 | New England Revolution | | - | | Orlando City SC | 4 | : | 1 |
| Jul 28 • 01:30 | New York Red Bulls | | - | | Columbus Crew | 2 | : | 3 |
| Jul 28 • 02:00 | Chicago Fire | | - | | Washington DC United | 0 | : | 0 |
| Jul 28 • 02:00 | FC Dallas | | - | | Real Salt Lake | 0 | : | 0 |
| Jul 28 • 02:00 | Houston Dynamo | | - | | Seattle Sounders | 0 | : | 1 |
| Jul 28 • 02:00 | Minnesota United | | - | | Vancouver Whitecaps | 0 | : | 0 |
| Jul 28 • 02:00 | Montreal Impact | | - | | Philadelphia Union | 4 | : | 0 |
| Jul 28 • 02:00 | Toronto FC | | - | | FC Cincinnati | 2 | : | 1 |
| Jul 28 • 04:00 | San Jose Earthquakes | | - | | Colorado Rapids | 3 | : | 1 |
| Jul 28 • 04:30 | Portland Timbers | | - | | Los Angeles Galaxy | 4 | : | 0 |
|
|
|
| Aug 03 • 23:00 | Atlanta United | | - | | Los Angeles Galaxy | 3 | : | 0 |
| Aug 04 • 00:00 | New York Red Bulls | | - | | Toronto FC | 2 | : | 0 |
| Aug 04 • 01:30 | New England Revolution | | - | | Los Angeles FC | 0 | : | 2 |
| Aug 04 • 01:30 | Orlando City SC | | - | | FC Dallas | 2 | : | 0 |
| Aug 04 • 02:00 | FC Cincinnati | | - | | Vancouver Whitecaps | 1 | : | 2 |
| Aug 04 • 03:00 | Colorado Rapids | | - | | Montreal Impact | 6 | : | 3 |
| Aug 04 • 03:00 | Houston Dynamo | | - | | Chicago Fire | 0 | : | 1 |
| Aug 04 • 04:00 | Real Salt Lake | | - | | New York City FC | 3 | : | 1 |
| Aug 04 • 04:00 | San Jose Earthquakes | | - | | Columbus Crew | 1 | : | 1 |
| Aug 04 • 22:00 | Minnesota United | | - | | Portland Timbers | 1 | : | 0 |
| Aug 05 • 01:30 | Washington DC United | | - | | Philadelphia Union | 1 | : | 5 |
| Aug 05 • 04:00 | Seattle Sounders | | - | | Sporting Kansas City | 2 | : | 3 |
|
|
|
| Aug 09 • 01:00 | New York City FC | | - | | Houston Dynamo | 3 | : | 2 |
| Aug 10 • 22:00 | Seattle Sounders | | - | | New England Revolution | 3 | : | 3 |
| Aug 11 • 01:30 | Columbus Crew | | - | | FC Cincinnati | 2 | : | 2 |
| Aug 11 • 01:30 | Toronto FC | | - | | Orlando City SC | 1 | : | 1 |
| Aug 11 • 02:00 | FC Dallas | | - | | Minnesota United | 5 | : | 3 |
| Aug 11 • 02:30 | Sporting Kansas City | | - | | Real Salt Lake | 1 | : | 2 |
| Aug 11 • 03:00 | Chicago Fire | | - | | Montreal Impact | 3 | : | 2 |
| Aug 11 • 03:00 | Colorado Rapids | | - | | San Jose Earthquakes | 2 | : | 1 |
| Aug 11 • 05:00 | Portland Timbers | | - | | Vancouver Whitecaps | 3 | : | 1 |
| Aug 11 • 21:55 | Atlanta United | | - | | New York City FC | 2 | : | 1 |
| Aug 12 • 00:00 | Philadelphia Union | | - | | Houston Dynamo | 2 | : | 1 |
| Aug 12 • 01:30 | Washington DC United | | - | | Los Angeles Galaxy | 2 | : | 1 |
| Aug 12 • 04:00 | Los Angeles FC | | - | | New York Red Bulls | 4 | : | 2 |
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| Aug 15 • 01:30 | Orlando City SC | | - | | Sporting Kansas City | 1 | : | 0 |
| Aug 15 • 02:00 | Minnesota United | | - | | Colorado Rapids | 1 | : | 0 |
| Aug 15 • 04:00 | Real Salt Lake | | - | | Seattle Sounders | 3 | : | 0 |
| Aug 15 • 04:30 | Los Angeles Galaxy | | - | | FC Dallas | 2 | : | 0 |
| Aug 15 • 05:00 | Portland Timbers | | - | | Chicago Fire | 3 | : | 2 |
| Aug 18 • 01:00 | New York Red Bulls | | - | | New England Revolution | 1 | : | 1 |
| Aug 18 • 01:30 | FC Cincinnati | | - | | New York City FC | 1 | : | 4 |
| Aug 18 • 01:30 | Columbus Crew | | - | | Toronto FC | 2 | : | 2 |
| Aug 18 • 01:30 | Montreal Impact | | - | | FC Dallas | 3 | : | 3 |
| Aug 18 • 02:00 | Chicago Fire | | - | | Philadelphia Union | 2 | : | 0 |
| Aug 18 • 02:00 | Minnesota United | | - | | Orlando City SC | 1 | : | 1 |
| Aug 18 • 02:30 | Sporting Kansas City | | - | | San Jose Earthquakes | 2 | : | 1 |
| Aug 18 • 03:00 | Houston Dynamo | | - | | Colorado Rapids | 2 | : | 2 |
| Aug 18 • 04:00 | Los Angeles Galaxy | | - | | Seattle Sounders | 2 | : | 2 |
| Aug 18 • 04:00 | Real Salt Lake | | - | | Los Angeles FC | 0 | : | 2 |
| Aug 18 • 04:00 | Vancouver Whitecaps | | - | | Washington DC United | 1 | : | 0 |
| Aug 19 • 04:00 | Portland Timbers | | - | | Atlanta United | 0 | : | 2 |
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| Aug 22 • 01:00 | New York City FC | | - | | Columbus Crew | 1 | : | 0 |
| Aug 22 • 02:00 | Washington DC United | | - | | New York Red Bulls | 1 | : | 2 |
| Aug 22 • 04:30 | Los Angeles FC | | - | | San Jose Earthquakes | 4 | : | 0 |
| Aug 23 • 03:30 | Sporting Kansas City | | - | | Minnesota United | 1 | : | 0 |
| Aug 24 • 02:00 | Orlando City SC | | - | | Atlanta United | 0 | : | 1 |
| Aug 24 • 04:00 | Portland Timbers | | - | | Seattle Sounders | 1 | : | 2 |
| Aug 25 • 01:00 | New York City FC | | - | | New York Red Bulls | 2 | : | 1 |
| Aug 25 • 01:30 | New England Revolution | | - | | Chicago Fire | 2 | : | 1 |
| Aug 25 • 01:30 | Philadelphia Union | | - | | Washington DC United | 3 | : | 1 |
| Aug 25 • 01:30 | Toronto FC | | - | | Montreal Impact | 2 | : | 1 |
| Aug 25 • 04:00 | Real Salt Lake | | - | | Colorado Rapids | 2 | : | 0 |
| Aug 25 • 04:00 | San Jose Earthquakes | | - | | Vancouver Whitecaps | 3 | : | 1 |
| Aug 26 • 00:00 | FC Cincinnati | | - | | Columbus Crew | 1 | : | 3 |
| Aug 26 • 02:00 | FC Dallas | | - | | Houston Dynamo | 5 | : | 1 |
| Aug 26 • 04:30 | Los Angeles FC | | - | | Los Angeles Galaxy | 3 | : | 3 |
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| Aug 29 • 02:00 | Montreal Impact | | - | | Vancouver Whitecaps | 2 | : | 1 |
| Sep 01 • 01:00 | New York Red Bulls | | - | | Colorado Rapids | 0 | : | 2 |
| Sep 01 • 01:30 | Columbus Crew | | - | | Chicago Fire | 1 | : | 1 |
| Sep 01 • 01:30 | Montreal Impact | | - | | Washington DC United | 0 | : | 3 |
| Sep 01 • 01:30 | New England Revolution | | - | | Toronto FC | 1 | : | 1 |
| Sep 01 • 01:30 | Philadelphia Union | | - | | Atlanta United | 3 | : | 1 |
| Sep 01 • 02:00 | FC Dallas | | - | | FC Cincinnati | 3 | : | 1 |
| Sep 01 • 02:30 | Sporting Kansas City | | - | | Houston Dynamo | 1 | : | 0 |
| Sep 01 • 04:00 | Vancouver Whitecaps | | - | | New York City FC | 1 | : | 3 |
| Sep 01 • 04:30 | Portland Timbers | | - | | Real Salt Lake | 1 | : | 0 |
| Sep 01 • 04:30 | San Jose Earthquakes | | - | | Orlando City SC | 3 | : | 0 |
| Sep 02 • 00:30 | Seattle Sounders | | - | | Los Angeles Galaxy | 4 | : | 3 |
| Sep 02 • 04:30 | Los Angeles FC | | - | | Minnesota United | 0 | : | 2 |
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| Sep 07 • 21:30 | New York City FC | | - | | New England Revolution | 2 | : | 1 |
| Sep 08 • 01:30 | FC Cincinnati | | - | | Toronto FC | 1 | : | 5 |
| Sep 08 • 01:30 | Orlando City SC | | - | | Los Angeles FC | 2 | : | 2 |
| Sep 08 • 03:00 | Colorado Rapids | | - | | Seattle Sounders | 2 | : | 0 |
| Sep 08 • 04:30 | Portland Timbers | | - | | Sporting Kansas City | 2 | : | 1 |
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| Sep 12 • 01:00 | New York City FC | | - | | Toronto FC | 1 | : | 1 |
| Sep 12 • 02:30 | Houston Dynamo | | - | | Minnesota United | 2 | : | 0 |
| Sep 12 • 03:00 | Colorado Rapids | | - | | Los Angeles Galaxy | 2 | : | 1 |
| Sep 12 • 03:30 | Real Salt Lake | | - | | San Jose Earthquakes | 1 | : | 0 |
| Sep 14 • 18:30 | New York City FC | | - | | San Jose Earthquakes | 2 | : | 1 |
| Sep 14 • 21:30 | Chicago Fire | | - | | FC Dallas | 4 | : | 0 |
| Sep 15 • 01:00 | Atlanta United | | - | | Columbus Crew | 1 | : | 3 |
| Sep 15 • 01:30 | Montreal Impact | | - | | FC Cincinnati | 0 | : | 1 |
| Sep 15 • 01:30 | Orlando City SC | | - | | New England Revolution | 3 | : | 3 |
| Sep 15 • 01:30 | Philadelphia Union | | - | | Los Angeles FC | 1 | : | 1 |
| Sep 15 • 04:00 | Vancouver Whitecaps | | - | | Houston Dynamo | 2 | : | 1 |
| Sep 15 • 21:30 | Portland Timbers | | - | | Washington DC United | 0 | : | 1 |
| Sep 15 • 23:00 | Toronto FC | | - | | Colorado Rapids | 3 | : | 2 |
| Sep 15 • 23:30 | Minnesota United | | - | | Real Salt Lake | 3 | : | 1 |
| Sep 16 • 00:00 | Seattle Sounders | | - | | New York Red Bulls | 4 | : | 2 |
| Sep 16 • 04:00 | Los Angeles Galaxy | | - | | Sporting Kansas City | 7 | : | 2 |
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| Sep 19 • 01:30 | FC Cincinnati | | - | | Atlanta United | 0 | : | 2 |
| Sep 19 • 04:30 | Portland Timbers | | - | | New York Red Bulls | 0 | : | 2 |
| Sep 19 • 04:30 | Seattle Sounders | | - | | FC Dallas | 0 | : | 0 |
| Sep 21 • 21:30 | Atlanta United | | - | | San Jose Earthquakes | 3 | : | 1 |
| Sep 21 • 23:00 | Vancouver Whitecaps | | - | | Columbus Crew | 1 | : | 1 |
| Sep 22 • 01:30 | FC Cincinnati | | - | | Chicago Fire | 0 | : | 0 |
| Sep 22 • 01:30 | New England Revolution | | - | | Real Salt Lake | 0 | : | 0 |
| Sep 22 • 02:30 | Houston Dynamo | | - | | Orlando City SC | 2 | : | 1 |
| Sep 22 • 02:30 | Sporting Kansas City | | - | | Colorado Rapids | 2 | : | 3 |
| Sep 22 • 04:30 | Los Angeles Galaxy | | - | | Montreal Impact | 2 | : | 1 |
| Sep 22 • 04:30 | Los Angeles FC | | - | | Toronto FC | 1 | : | 1 |
| Sep 22 • 21:55 | Portland Timbers | | - | | Minnesota United | 0 | : | 0 |
| Sep 23 • 00:00 | FC Dallas | | - | | New York City FC | 1 | : | 1 |
| Sep 23 • 00:30 | New York Red Bulls | | - | | Philadelphia Union | 2 | : | 0 |
| Sep 23 • 02:00 | Washington DC United | | - | | Seattle Sounders | 2 | : | 0 |
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| Sep 26 • 01:00 | New York City FC | | - | | Atlanta United | 4 | : | 1 |
| Sep 26 • 02:00 | Minnesota United | | - | | Sporting Kansas City | 2 | : | 1 |
| Sep 26 • 03:30 | Real Salt Lake | | - | | Los Angeles Galaxy | 1 | : | 2 |
| Sep 26 • 04:30 | Los Angeles FC | | - | | Houston Dynamo | 3 | : | 1 |
| Sep 26 • 04:30 | Portland Timbers | | - | | New England Revolution | 2 | : | 2 |
| Sep 26 • 05:00 | San Jose Earthquakes | | - | | Philadelphia Union | 1 | : | 2 |
| Sep 29 • 23:00 | Chicago Fire | | - | | Toronto FC | 2 | : | 2 |
| Sep 29 • 23:00 | FC Cincinnati | | - | | Orlando City SC | 1 | : | 1 |
| Sep 29 • 23:00 | Columbus Crew | | - | | Philadelphia Union | 2 | : | 0 |
| Sep 29 • 23:00 | Montreal Impact | | - | | Atlanta United | 1 | : | 1 |
| Sep 29 • 23:00 | New England Revolution | | - | | New York City FC | 2 | : | 0 |
| Sep 29 • 23:00 | New York Red Bulls | | - | | Washington DC United | 0 | : | 0 |
| Sep 30 • 01:30 | Colorado Rapids | | - | | FC Dallas | 3 | : | 0 |
| Sep 30 • 01:30 | Sporting Kansas City | | - | | Portland Timbers | 2 | : | 2 |
| Sep 30 • 01:30 | Los Angeles Galaxy | | - | | Vancouver Whitecaps | 3 | : | 4 |
| Sep 30 • 01:30 | Minnesota United | | - | | Los Angeles FC | 1 | : | 1 |
| Sep 30 • 01:30 | Real Salt Lake | | - | | Houston Dynamo | 2 | : | 1 |
| Sep 30 • 01:30 | San Jose Earthquakes | | - | | Seattle Sounders | 0 | : | 1 |
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| Oct 06 • 22:00 | Atlanta United | | - | | New England Revolution | 3 | : | 1 |
| Oct 06 • 22:00 | FC Dallas | | - | | Sporting Kansas City | 6 | : | 0 |
| Oct 06 • 22:00 | Washington DC United | | - | | FC Cincinnati | 0 | : | 0 |
| Oct 06 • 22:00 | Houston Dynamo | | - | | Los Angeles Galaxy | 4 | : | 2 |
| Oct 06 • 22:00 | Los Angeles FC | | - | | Colorado Rapids | 3 | : | 1 |
| Oct 06 • 22:00 | Montreal Impact | | - | | New York Red Bulls | 3 | : | 0 |
| Oct 06 • 22:00 | Orlando City SC | | - | | Chicago Fire | 2 | : | 5 |
| Oct 06 • 22:00 | Philadelphia Union | | - | | New York City FC | 1 | : | 2 |
| Oct 06 • 22:00 | Portland Timbers | | - | | San Jose Earthquakes | 3 | : | 1 |
| Oct 06 • 22:00 | Seattle Sounders | | - | | Minnesota United | 1 | : | 0 |
| Oct 06 • 22:00 | Toronto FC | | - | | Columbus Crew | 1 | : | 0 |
| Oct 06 • 22:00 | Vancouver Whitecaps | | - | | Real Salt Lake | 0 | : | 1 |
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| Oct 19 • 19:00 | Atlanta United | | - | | New England Revolution | 1 | : | 0 |
| Oct 19 • 21:30 | Seattle Sounders | | - | | FC Dallas | 4 | : | 3 |
| Oct 20 • 00:00 | Toronto FC | | - | | Washington DC United | 5 | : | 1 |
| Oct 20 • 04:00 | Real Salt Lake | | - | | Portland Timbers | 2 | : | 1 |
| Oct 20 • 21:00 | Philadelphia Union | | - | | New York Red Bulls | 4 | : | 3 |
| Oct 21 • 02:30 | Minnesota United | | - | | Los Angeles Galaxy | 1 | : | 2 |
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| Oct 24 • 01:00 | New York City FC | | - | | Toronto FC | 1 | : | 2 |
| Oct 24 • 04:00 | Seattle Sounders | | - | | Real Salt Lake | 2 | : | 0 |
| Oct 25 • 02:00 | Atlanta United | | - | | Philadelphia Union | 2 | : | 0 |
| Oct 25 • 04:30 | Los Angeles FC | | - | | Los Angeles Galaxy | 5 | : | 3 |
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| Oct 30 • 03:00 | Los Angeles FC | | - | | Seattle Sounders | 1 | : | 3 |
| Oct 31 • 01:00 | Atlanta United | | - | | Toronto FC | 1 | : | 2 |
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| Nov 10 • 21:00 | Seattle Sounders | | - | | Toronto FC | 3 | : | 1 |
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