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|
| Feb 26 • 19:00 | Philadelphia Union |  | - |  | Minnesota United | 1 | : | 1 |
| Feb 26 • 21:30 | Columbus Crew |  | - |  | Vancouver Whitecaps | 4 | : | 0 |
| Feb 26 • 21:30 | Los Angeles FC |  | - |  | Colorado Rapids | 3 | : | 0 |
| Feb 26 • 23:30 | FC Dallas |  | - |  | Toronto FC | 1 | : | 1 |
| Feb 27 • 00:00 | Washington DC United |  | - |  | Charlotte FC | 3 | : | 0 |
| Feb 27 • 00:00 | Austin FC |  | - |  | FC Cincinnati | 5 | : | 0 |
| Feb 27 • 00:00 | Inter Miami |  | - |  | Chicago Fire | 0 | : | 0 |
| Feb 27 • 00:00 | San Jose Earthquakes |  | - |  | New York Red Bulls | 1 | : | 3 |
| Feb 27 • 01:30 | Portland Timbers |  | - |  | New England Revolution | 2 | : | 2 |
| Feb 27 • 19:00 | Orlando City SC |  | - |  | CF Montreal | 2 | : | 0 |
| Feb 27 • 21:00 | Atlanta United |  | - |  | Sporting Kansas City | 3 | : | 1 |
| Feb 27 • 23:00 | Los Angeles Galaxy |  | - |  | New York City FC | 1 | : | 0 |
| Feb 28 • 01:00 | Houston Dynamo |  | - |  | Real Salt Lake | 0 | : | 0 |
| Feb 28 • 02:00 | Seattle Sounders |  | - |  | Nashville SC | 0 | : | 1 |
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| Mar 05 • 19:30 | New England Revolution | | - | | FC Dallas | 1 | : | 0 |
| Mar 05 • 20:00 | Toronto FC | | - | | New York Red Bulls | 1 | : | 4 |
| Mar 05 • 21:30 | Sporting Kansas City | | - | | Houston Dynamo | 1 | : | 0 |
| Mar 05 • 22:00 | CF Montreal | | - | | Philadelphia Union | 1 | : | 2 |
| Mar 05 • 23:30 | San Jose Earthquakes | | - | | Columbus Crew | 3 | : | 3 |
| Mar 06 • 00:00 | FC Cincinnati | | - | | Washington DC United | 0 | : | 1 |
| Mar 06 • 00:00 | Chicago Fire | | - | | Orlando City SC | 0 | : | 0 |
| Mar 06 • 00:00 | Minnesota United | | - | | Nashville SC | 1 | : | 1 |
| Mar 06 • 00:00 | Colorado Rapids | | - | | Atlanta United | 3 | : | 0 |
| Mar 06 • 00:00 | Real Salt Lake | | - | | Seattle Sounders | 1 | : | 0 |
| Mar 06 • 00:00 | Vancouver Whitecaps | | - | | New York City FC | 0 | : | 0 |
| Mar 06 • 01:30 | Charlotte FC | | - | | Los Angeles Galaxy | 0 | : | 1 |
| Mar 06 • 22:00 | Austin FC | | - | | Inter Miami | 5 | : | 1 |
| Mar 07 • 04:00 | Los Angeles FC | | - | | Portland Timbers | 1 | : | 1 |
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|
| Mar 12 • 19:00 | New York City FC | | - | | CF Montreal | 4 | : | 1 |
| Mar 12 • 19:30 | Columbus Crew | | - | | Toronto FC | 2 | : | 1 |
| Mar 12 • 19:30 | Inter Miami | | - | | Los Angeles FC | 0 | : | 2 |
| Mar 12 • 21:30 | Seattle Sounders | | - | | Los Angeles Galaxy | 3 | : | 2 |
| Mar 13 • 00:30 | Houston Dynamo | | - | | Vancouver Whitecaps | 2 | : | 1 |
| Mar 13 • 01:30 | Washington DC United | | - | | Chicago Fire | 0 | : | 2 |
| Mar 13 • 01:30 | New England Revolution | | - | | Real Salt Lake | 2 | : | 3 |
| Mar 13 • 01:30 | Orlando City SC | | - | | FC Cincinnati | 1 | : | 2 |
| Mar 13 • 01:30 | Philadelphia Union | | - | | San Jose Earthquakes | 2 | : | 0 |
| Mar 13 • 02:30 | FC Dallas | | - | | Nashville SC | 2 | : | 0 |
| Mar 13 • 03:00 | Colorado Rapids | | - | | Sporting Kansas City | 2 | : | 0 |
| Mar 13 • 04:00 | Portland Timbers | | - | | Austin FC | 1 | : | 0 |
| Mar 13 • 21:30 | Atlanta United | | - | | Charlotte FC | 2 | : | 1 |
| Mar 14 • 00:00 | New York Red Bulls | | - | | Minnesota United | 0 | : | 1 |
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| Mar 19 • 18:00 | FC Cincinnati | | - | | Inter Miami | 3 | : | 1 |
| Mar 19 • 18:00 | New York City FC | | - | | Philadelphia Union | 0 | : | 2 |
| Mar 19 • 20:00 | Toronto FC | | - | | Washington DC United | 2 | : | 1 |
| Mar 19 • 20:30 | Los Angeles Galaxy | | - | | Orlando City SC | 0 | : | 1 |
| Mar 19 • 21:00 | Atlanta United | | - | | CF Montreal | 3 | : | 3 |
| Mar 19 • 23:00 | Chicago Fire | | - | | Sporting Kansas City | 3 | : | 1 |
| Mar 20 • 00:00 | Charlotte FC | | - | | New England Revolution | 3 | : | 1 |
| Mar 20 • 01:00 | Minnesota United | | - | | San Jose Earthquakes | 1 | : | 0 |
| Mar 20 • 01:30 | Houston Dynamo | | - | | Colorado Rapids | 1 | : | 1 |
| Mar 20 • 01:30 | FC Dallas | | - | | Portland Timbers | 4 | : | 1 |
| Mar 20 • 02:30 | Real Salt Lake | | - | | Nashville SC | 2 | : | 1 |
| Mar 20 • 19:00 | New York Red Bulls | | - | | Columbus Crew | 1 | : | 1 |
| Mar 20 • 21:30 | Austin FC | | - | | Seattle Sounders | 1 | : | 1 |
| Mar 21 • 03:00 | Los Angeles FC | | - | | Vancouver Whitecaps | 3 | : | 1 |
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|
|
| Mar 26 • 22:00 | Charlotte FC | | - | | FC Cincinnati | 2 | : | 0 |
| Mar 27 • 00:00 | Sporting Kansas City | | - | | Real Salt Lake | 1 | : | 0 |
| Mar 27 • 22:00 | Portland Timbers | | - | | Orlando City SC | 1 | : | 1 |
| Apr 02 • 21:30 | Chicago Fire | | - | | FC Dallas | 0 | : | 0 |
| Apr 02 • 22:00 | FC Cincinnati | | - | | CF Montreal | 3 | : | 4 |
| Apr 02 • 22:00 | Toronto FC | | - | | New York City FC | 2 | : | 1 |
| Apr 03 • 00:00 | Columbus Crew | | - | | Nashville SC | 0 | : | 1 |
| Apr 03 • 01:30 | Washington DC United | | - | | Atlanta United | 0 | : | 1 |
| Apr 03 • 01:30 | New England Revolution | | - | | New York Red Bulls | 0 | : | 1 |
| Apr 03 • 01:30 | Orlando City SC | | - | | Los Angeles FC | 2 | : | 4 |
| Apr 03 • 01:30 | Philadelphia Union | | - | | Charlotte FC | 2 | : | 0 |
| Apr 03 • 01:30 | San Jose Earthquakes | | - | | Austin FC | 2 | : | 2 |
| Apr 03 • 02:00 | Inter Miami | | - | | Houston Dynamo | 1 | : | 3 |
| Apr 03 • 02:00 | Minnesota United | | - | | Seattle Sounders | 1 | : | 2 |
| Apr 03 • 02:00 | Vancouver Whitecaps | | - | | Sporting Kansas City | 1 | : | 0 |
| Apr 03 • 03:00 | Colorado Rapids | | - | | Real Salt Lake | 1 | : | 1 |
| Apr 03 • 22:30 | Portland Timbers | | - | | Los Angeles Galaxy | 1 | : | 3 |
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|
|
| Apr 09 • 19:00 | Orlando City SC | | - | | Chicago Fire | 1 | : | 0 |
| Apr 09 • 21:00 | Inter Miami | | - | | New England Revolution | 3 | : | 2 |
| Apr 09 • 22:00 | New York Red Bulls | | - | | CF Montreal | 1 | : | 2 |
| Apr 10 • 00:00 | Philadelphia Union | | - | | Columbus Crew | 1 | : | 0 |
| Apr 10 • 01:30 | Los Angeles Galaxy | | - | | Los Angeles FC | 2 | : | 1 |
| Apr 10 • 02:00 | Real Salt Lake | | - | | Toronto FC | 2 | : | 2 |
| Apr 10 • 02:30 | FC Dallas | | - | | Colorado Rapids | 3 | : | 1 |
| Apr 10 • 02:30 | Houston Dynamo | | - | | San Jose Earthquakes | 4 | : | 3 |
| Apr 10 • 02:30 | Sporting Kansas City | | - | | Nashville SC | 1 | : | 2 |
| Apr 10 • 04:00 | Vancouver Whitecaps | | - | | Portland Timbers | 2 | : | 3 |
| Apr 10 • 19:30 | Charlotte FC | | - | | Atlanta United | 1 | : | 0 |
| Apr 11 • 01:30 | Austin FC | | - | | Minnesota United | 1 | : | 0 |
|
|
|
| Apr 16 • 21:00 | CF Montreal | | - | | Vancouver Whitecaps | 2 | : | 1 |
| Apr 16 • 21:30 | San Jose Earthquakes | | - | | Nashville SC | 2 | : | 2 |
| Apr 17 • 00:00 | Atlanta United | | - | | FC Cincinnati | 0 | : | 0 |
| Apr 17 • 00:00 | Houston Dynamo | | - | | Portland Timbers | 0 | : | 0 |
| Apr 17 • 01:00 | New York Red Bulls | | - | | FC Dallas | 0 | : | 0 |
| Apr 17 • 01:30 | Columbus Crew | | - | | Orlando City SC | 0 | : | 2 |
| Apr 17 • 01:30 | Washington DC United | | - | | Austin FC | 2 | : | 3 |
| Apr 17 • 01:30 | New England Revolution | | - | | Charlotte FC | 2 | : | 1 |
| Apr 17 • 01:30 | Toronto FC | | - | | Philadelphia Union | 2 | : | 1 |
| Apr 17 • 02:00 | Chicago Fire | | - | | Los Angeles Galaxy | 0 | : | 0 |
| Apr 17 • 02:00 | Minnesota United | | - | | Colorado Rapids | 3 | : | 1 |
| Apr 17 • 04:00 | Seattle Sounders | | - | | Inter Miami | 0 | : | 1 |
| Apr 17 • 19:00 | New York City FC | | - | | Real Salt Lake | 6 | : | 0 |
| Apr 17 • 22:00 | Los Angeles FC | | - | | Sporting Kansas City | 3 | : | 1 |
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| Apr 23 • 21:00 | FC Dallas | | - | | Houston Dynamo | 2 | : | 1 |
| Apr 23 • 21:00 | Philadelphia Union | | - | | CF Montreal | 1 | : | 1 |
| Apr 23 • 23:00 | Minnesota United | | - | | Chicago Fire | 3 | : | 0 |
| Apr 24 • 01:30 | Washington DC United | | - | | New England Revolution | 3 | : | 2 |
| Apr 24 • 02:30 | Austin FC | | - | | Vancouver Whitecaps | 3 | : | 0 |
| Apr 24 • 02:30 | Sporting Kansas City | | - | | Columbus Crew | 0 | : | 0 |
| Apr 24 • 03:00 | Colorado Rapids | | - | | Charlotte FC | 0 | : | 0 |
| Apr 24 • 04:00 | Portland Timbers | | - | | Real Salt Lake | 0 | : | 0 |
| Apr 24 • 04:00 | San Jose Earthquakes | | - | | Seattle Sounders | 4 | : | 3 |
| Apr 24 • 04:30 | Los Angeles Galaxy | | - | | Nashville SC | 1 | : | 0 |
| Apr 24 • 19:00 | Inter Miami | | - | | Atlanta United | 2 | : | 1 |
| Apr 24 • 21:30 | Orlando City SC | | - | | New York Red Bulls | 0 | : | 3 |
| Apr 24 • 23:00 | FC Cincinnati | | - | | Los Angeles FC | 1 | : | 2 |
| Apr 24 • 23:00 | New York City FC | | - | | Toronto FC | 5 | : | 4 |
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|
|
| Apr 30 • 19:30 | Houston Dynamo | | - | | Austin FC | 1 | : | 2 |
| Apr 30 • 21:00 | Toronto FC | | - | | FC Cincinnati | 1 | : | 2 |
| Apr 30 • 21:30 | Real Salt Lake | | - | | Los Angeles Galaxy | 1 | : | 0 |
| Apr 30 • 22:00 | CF Montreal | | - | | Atlanta United | 2 | : | 1 |
| May 01 • 01:30 | New England Revolution | | - | | Inter Miami | 2 | : | 0 |
| May 01 • 01:30 | Columbus Crew | | - | | Washington DC United | 3 | : | 0 |
| May 01 • 01:30 | Orlando City SC | | - | | Charlotte FC | 2 | : | 1 |
| May 01 • 02:00 | Chicago Fire | | - | | New York Red Bulls | 1 | : | 2 |
| May 01 • 02:30 | Sporting Kansas City | | - | | FC Dallas | 2 | : | 2 |
| May 01 • 03:00 | Colorado Rapids | | - | | Portland Timbers | 2 | : | 0 |
| May 01 • 19:00 | New York City FC | | - | | San Jose Earthquakes | 3 | : | 0 |
| May 01 • 22:00 | Nashville SC | | - | | Philadelphia Union | 1 | : | 1 |
| May 02 • 04:00 | Los Angeles FC | | - | | Minnesota United | 2 | : | 0 |
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| May 05 • 01:30 | FC Cincinnati | | - | | Toronto FC | 2 | : | 0 |
| May 07 • 21:30 | Charlotte FC | | - | | Inter Miami | 1 | : | 0 |
| May 07 • 22:00 | CF Montreal | | - | | Orlando City SC | 4 | : | 1 |
| May 08 • 00:00 | Atlanta United | | - | | Chicago Fire | 4 | : | 1 |
| May 08 • 01:00 | New York Red Bulls | | - | | Portland Timbers | 1 | : | 1 |
| May 08 • 01:00 | New York City FC | | - | | Sporting Kansas City | 0 | : | 0 |
| May 08 • 01:30 | Washington DC United | | - | | Houston Dynamo | 2 | : | 0 |
| May 08 • 01:30 | New England Revolution | | - | | Columbus Crew | 2 | : | 2 |
| May 08 • 02:00 | Minnesota United | | - | | FC Cincinnati | 0 | : | 1 |
| May 08 • 02:30 | FC Dallas | | - | | Seattle Sounders | 2 | : | 0 |
| May 08 • 04:00 | San Jose Earthquakes | | - | | Colorado Rapids | 1 | : | 0 |
| May 08 • 05:00 | Los Angeles FC | | - | | Philadelphia Union | 2 | : | 2 |
| May 08 • 22:00 | Vancouver Whitecaps | | - | | Toronto FC | 1 | : | 0 |
| May 08 • 23:00 | Nashville SC | | - | | Real Salt Lake | 2 | : | 0 |
| May 09 • 01:25 | Austin FC | | - | | Los Angeles Galaxy | 0 | : | 1 |
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| May 14 • 21:00 | Toronto FC | | - | | Orlando City SC | 0 | : | 1 |
| May 14 • 21:30 | Colorado Rapids | | - | | Los Angeles FC | 2 | : | 0 |
| May 15 • 01:00 | Charlotte FC | | - | | CF Montreal | 0 | : | 2 |
| May 15 • 01:00 | New York City FC | | - | | Columbus Crew | 2 | : | 0 |
| May 15 • 01:00 | Vancouver Whitecaps | | - | | San Jose Earthquakes | 3 | : | 3 |
| May 15 • 01:30 | Philadelphia Union | | - | | New York Red Bulls | 1 | : | 1 |
| May 15 • 02:00 | Chicago Fire | | - | | FC Cincinnati | 1 | : | 2 |
| May 15 • 02:00 | Inter Miami | | - | | Washington DC United | 2 | : | 2 |
| May 15 • 02:30 | Houston Dynamo | | - | | Nashville SC | 2 | : | 0 |
| May 15 • 03:30 | Real Salt Lake | | - | | Austin FC | 2 | : | 1 |
| May 15 • 04:00 | Portland Timbers | | - | | Sporting Kansas City | 7 | : | 2 |
| May 15 • 04:30 | Los Angeles Galaxy | | - | | FC Dallas | 1 | : | 3 |
| May 15 • 19:30 | Atlanta United | | - | | New England Revolution | 2 | : | 2 |
| May 15 • 22:00 | Seattle Sounders | | - | | Minnesota United | 3 | : | 1 |
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| May 19 • 01:30 | Washington DC United | | - | | New York City FC | 0 | : | 2 |
| May 19 • 01:30 | New York Red Bulls | | - | | Chicago Fire | 3 | : | 3 |
| May 19 • 01:30 | Philadelphia Union | | - | | Inter Miami | 0 | : | 0 |
| May 19 • 02:00 | Minnesota United | | - | | Los Angeles Galaxy | 1 | : | 1 |
| May 19 • 02:30 | Houston Dynamo | | - | | Seattle Sounders | 0 | : | 1 |
| May 19 • 02:30 | Sporting Kansas City | | - | | Colorado Rapids | 2 | : | 1 |
| May 19 • 02:30 | Nashville SC | | - | | CF Montreal | 2 | : | 1 |
| May 19 • 04:00 | Vancouver Whitecaps | | - | | FC Dallas | 2 | : | 1 |
| May 19 • 04:30 | Los Angeles FC | | - | | Austin FC | 1 | : | 2 |
| May 19 • 04:30 | San Jose Earthquakes | | - | | Portland Timbers | 3 | : | 2 |
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|
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| May 21 • 21:30 | Columbus Crew | | - | | Los Angeles FC | 0 | : | 2 |
| May 21 • 22:00 | Washington DC United | | - | | Toronto FC | 2 | : | 2 |
| May 22 • 00:00 | FC Cincinnati | | - | | New England Revolution | 2 | : | 3 |
| May 22 • 01:30 | Nashville SC | | - | | Atlanta United | 2 | : | 2 |
| May 22 • 22:00 | CF Montreal | | - | | Real Salt Lake | 1 | : | 2 |
| May 22 • 23:00 | Charlotte FC | | - | | Vancouver Whitecaps | 2 | : | 1 |
| May 22 • 23:00 | New York City FC | | - | | Chicago Fire | 1 | : | 0 |
| May 23 • 00:00 | Inter Miami | | - | | New York Red Bulls | 2 | : | 0 |
| May 23 • 01:00 | FC Dallas | | - | | Minnesota United | 1 | : | 2 |
| May 23 • 01:30 | San Jose Earthquakes | | - | | Sporting Kansas City | 1 | : | 1 |
| May 23 • 02:00 | Austin FC | | - | | Orlando City SC | 2 | : | 2 |
| May 23 • 02:00 | Colorado Rapids | | - | | Seattle Sounders | 1 | : | 0 |
| May 23 • 02:00 | Los Angeles Galaxy | | - | | Houston Dynamo | 0 | : | 3 |
| May 23 • 04:00 | Portland Timbers | | - | | Philadelphia Union | 0 | : | 2 |
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|
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| May 29 • 00:00 | Los Angeles FC | | - | | San Jose Earthquakes | 3 | : | 2 |
| May 29 • 01:00 | Atlanta United | | - | | Columbus Crew | 1 | : | 2 |
| May 29 • 01:00 | New York Red Bulls | | - | | Washington DC United | 4 | : | 1 |
| May 29 • 01:00 | Toronto FC | | - | | Chicago Fire | 3 | : | 2 |
| May 29 • 01:30 | CF Montreal | | - | | FC Cincinnati | 4 | : | 3 |
| May 29 • 01:30 | New England Revolution | | - | | Philadelphia Union | 1 | : | 1 |
| May 29 • 01:30 | Orlando City SC | | - | | FC Dallas | 1 | : | 3 |
| May 29 • 02:00 | Inter Miami | | - | | Portland Timbers | 2 | : | 1 |
| May 29 • 02:00 | Minnesota United | | - | | New York City FC | 0 | : | 1 |
| May 29 • 03:00 | Colorado Rapids | | - | | Nashville SC | 1 | : | 3 |
| May 29 • 03:00 | Sporting Kansas City | | - | | Vancouver Whitecaps | 0 | : | 1 |
| May 29 • 03:30 | Real Salt Lake | | - | | Houston Dynamo | 3 | : | 0 |
| May 30 • 00:00 | Los Angeles Galaxy | | - | | Austin FC | 4 | : | 1 |
| May 30 • 03:55 | Seattle Sounders | | - | | Charlotte FC | 2 | : | 1 |
| Jun 05 • 01:00 | Vancouver Whitecaps | | - | | Real Salt Lake | 2 | : | 1 |
| Jun 11 • 21:00 | Charlotte FC | | - | | New York Red Bulls | 2 | : | 0 |
| Jun 12 • 02:00 | Nashville SC | | - | | San Jose Earthquakes | 0 | : | 0 |
| Jun 12 • 21:00 | Sporting Kansas City | | - | | New England Revolution | 1 | : | 2 |
| Jun 15 • 04:30 | Seattle Sounders | | - | | Vancouver Whitecaps | 4 | : | 0 |
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| Jun 18 • 21:00 | Seattle Sounders | | - | | Los Angeles FC | 1 | : | 1 |
| Jun 18 • 23:00 | Los Angeles Galaxy | | - | | Portland Timbers | 1 | : | 1 |
| Jun 19 • 01:00 | New York Red Bulls | | - | | Toronto FC | 2 | : | 0 |
| Jun 19 • 01:30 | Columbus Crew | | - | | Charlotte FC | 1 | : | 1 |
| Jun 19 • 01:30 | CF Montreal | | - | | Austin FC | 0 | : | 1 |
| Jun 19 • 01:30 | Orlando City SC | | - | | Houston Dynamo | 2 | : | 1 |
| Jun 19 • 01:30 | Philadelphia Union | | - | | FC Cincinnati | 1 | : | 1 |
| Jun 19 • 02:00 | Chicago Fire | | - | | Washington DC United | 1 | : | 0 |
| Jun 19 • 03:00 | FC Dallas | | - | | Vancouver Whitecaps | 0 | : | 2 |
| Jun 19 • 03:30 | Real Salt Lake | | - | | San Jose Earthquakes | 2 | : | 0 |
| Jun 19 • 21:00 | Atlanta United | | - | | Inter Miami | 2 | : | 0 |
| Jun 19 • 23:00 | New England Revolution | | - | | Minnesota United | 2 | : | 1 |
| Jun 19 • 23:00 | New York City FC | | - | | Colorado Rapids | 1 | : | 1 |
| Jun 20 • 00:00 | Nashville SC | | - | | Sporting Kansas City | 1 | : | 2 |
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| Jun 25 • 01:30 | FC Cincinnati | | - | | Orlando City SC | 1 | : | 0 |
| Jun 25 • 21:00 | Seattle Sounders | | - | | Sporting Kansas City | 3 | : | 0 |
| Jun 25 • 23:00 | Washington DC United | | - | | Nashville SC | 1 | : | 3 |
| Jun 26 • 01:30 | CF Montreal | | - | | Charlotte FC | 2 | : | 1 |
| Jun 26 • 01:30 | Toronto FC | | - | | Atlanta United | 2 | : | 1 |
| Jun 26 • 02:00 | Houston Dynamo | | - | | Chicago Fire | 2 | : | 0 |
| Jun 26 • 02:00 | Inter Miami | | - | | Minnesota United | 2 | : | 1 |
| Jun 26 • 03:00 | Austin FC | | - | | FC Dallas | 2 | : | 2 |
| Jun 26 • 04:00 | Real Salt Lake | | - | | Columbus Crew | 0 | : | 0 |
| Jun 26 • 04:30 | Portland Timbers | | - | | Colorado Rapids | 3 | : | 0 |
| Jun 26 • 21:00 | Los Angeles FC | | - | | New York Red Bulls | 2 | : | 0 |
| Jun 27 • 00:00 | Philadelphia Union | | - | | New York City FC | 2 | : | 1 |
| Jun 27 • 02:00 | Vancouver Whitecaps | | - | | New England Revolution | 0 | : | 0 |
|
|
|
| Jun 16 • 01:30 | New England Revolution | | - | | Orlando City SC | 1 | : | 1 |
| Jun 30 • 01:30 | FC Cincinnati | | - | | New York City FC | 4 | : | 4 |
| Jun 30 • 01:30 | Toronto FC | | - | | Columbus Crew | 1 | : | 2 |
| Jun 30 • 02:00 | Chicago Fire | | - | | Philadelphia Union | 1 | : | 0 |
| Jun 30 • 04:00 | Seattle Sounders | | - | | CF Montreal | 1 | : | 2 |
| Jun 30 • 04:30 | Los Angeles FC | | - | | FC Dallas | 3 | : | 1 |
| Jun 30 • 04:30 | Portland Timbers | | - | | Houston Dynamo | 2 | : | 1 |
| Jun 30 • 04:30 | Los Angeles Galaxy | | - | | Minnesota United | 2 | : | 3 |
| Jul 01 • 01:00 | Charlotte FC | | - | | Austin FC | 0 | : | 1 |
| Jul 01 • 02:00 | New York Red Bulls | | - | | Atlanta United | 2 | : | 1 |
|
|
|
| Jul 03 • 01:30 | Toronto FC | | - | | Seattle Sounders | 0 | : | 2 |
| Jul 03 • 04:00 | Vancouver Whitecaps | | - | | Los Angeles FC | 1 | : | 0 |
| Jul 03 • 23:00 | New York City FC | | - | | Atlanta United | 2 | : | 2 |
| Jul 04 • 01:30 | Columbus Crew | | - | | Philadelphia Union | 0 | : | 0 |
| Jul 04 • 01:30 | New England Revolution | | - | | FC Cincinnati | 2 | : | 2 |
| Jul 04 • 02:00 | Minnesota United | | - | | Real Salt Lake | 3 | : | 2 |
| Jul 04 • 02:00 | Sporting Kansas City | | - | | New York Red Bulls | 0 | : | 1 |
| Jul 04 • 02:30 | Houston Dynamo | | - | | Charlotte FC | 1 | : | 2 |
| Jul 04 • 02:30 | Nashville SC | | - | | Portland Timbers | 2 | : | 2 |
| Jul 04 • 03:00 | San Jose Earthquakes | | - | | Chicago Fire | 2 | : | 1 |
| Jul 05 • 01:00 | Orlando City SC | | - | | Washington DC United | 3 | : | 5 |
| Jul 05 • 03:00 | Colorado Rapids | | - | | Austin FC | 2 | : | 3 |
| Jul 05 • 03:00 | FC Dallas | | - | | Inter Miami | 1 | : | 1 |
| Jul 05 • 04:30 | Los Angeles Galaxy | | - | | CF Montreal | 4 | : | 0 |
|
|
|
| Jul 09 • 01:30 | Philadelphia Union | | - | | Washington DC United | 7 | : | 0 |
| Jul 09 • 04:00 | Los Angeles FC | | - | | Los Angeles Galaxy | 3 | : | 2 |
| Jul 09 • 04:30 | Vancouver Whitecaps | | - | | Minnesota United | 1 | : | 3 |
| Jul 09 • 19:00 | New York City FC | | - | | New England Revolution | 4 | : | 2 |
| Jul 09 • 22:30 | Seattle Sounders | | - | | Portland Timbers | 0 | : | 3 |
| Jul 10 • 01:00 | Atlanta United | | - | | Austin FC | 0 | : | 3 |
| Jul 10 • 01:00 | Charlotte FC | | - | | Nashville SC | 4 | : | 1 |
| Jul 10 • 01:30 | FC Cincinnati | | - | | New York Red Bulls | 1 | : | 1 |
| Jul 10 • 01:30 | CF Montreal | | - | | Sporting Kansas City | 1 | : | 2 |
| Jul 10 • 01:30 | Toronto FC | | - | | San Jose Earthquakes | 2 | : | 2 |
| Jul 10 • 02:00 | Orlando City SC | | - | | Inter Miami | 1 | : | 0 |
| Jul 10 • 02:00 | Chicago Fire | | - | | Columbus Crew | 2 | : | 3 |
| Jul 10 • 02:30 | Houston Dynamo | | - | | FC Dallas | 2 | : | 2 |
| Jul 10 • 04:00 | Real Salt Lake | | - | | Colorado Rapids | 2 | : | 2 |
|
|
|
| Jul 13 • 03:00 | Austin FC | | - | | Houston Dynamo | 3 | : | 1 |
| Jul 14 • 01:30 | Atlanta United | | - | | Real Salt Lake | 2 | : | 1 |
| Jul 14 • 02:00 | Chicago Fire | | - | | Toronto FC | 2 | : | 0 |
| Jul 14 • 02:00 | FC Cincinnati | | - | | Vancouver Whitecaps | 2 | : | 2 |
| Jul 14 • 02:00 | Washington DC United | | - | | Columbus Crew | 2 | : | 2 |
| Jul 14 • 02:00 | Inter Miami | | - | | Philadelphia Union | 1 | : | 2 |
| Jul 14 • 02:00 | Minnesota United | | - | | Sporting Kansas City | 1 | : | 1 |
| Jul 14 • 02:30 | Nashville SC | | - | | Seattle Sounders | 1 | : | 0 |
| Jul 14 • 03:00 | Colorado Rapids | | - | | Orlando City SC | 1 | : | 1 |
| Jul 14 • 03:00 | FC Dallas | | - | | New York City FC | 0 | : | 1 |
| Jul 14 • 04:00 | Los Angeles Galaxy | | - | | San Jose Earthquakes | 2 | : | 3 |
|
|
|
| Jul 17 • 01:30 | CF Montreal | | - | | Toronto FC | 1 | : | 0 |
| Jul 17 • 01:30 | Philadelphia Union | | - | | New England Revolution | 2 | : | 1 |
| Jul 17 • 02:00 | Chicago Fire | | - | | Seattle Sounders | 1 | : | 0 |
| Jul 17 • 02:00 | Inter Miami | | - | | Charlotte FC | 3 | : | 2 |
| Jul 17 • 02:00 | Minnesota United | | - | | Washington DC United | 2 | : | 0 |
| Jul 17 • 03:00 | Colorado Rapids | | - | | Los Angeles Galaxy | 2 | : | 0 |
| Jul 17 • 03:00 | FC Dallas | | - | | Austin FC | 1 | : | 1 |
| Jul 17 • 21:00 | Atlanta United | | - | | Orlando City SC | 1 | : | 1 |
| Jul 17 • 23:00 | New York Red Bulls | | - | | New York City FC | 0 | : | 1 |
| Jul 18 • 01:30 | Columbus Crew | | - | | FC Cincinnati | 2 | : | 0 |
| Jul 18 • 02:30 | Nashville SC | | - | | Los Angeles FC | 1 | : | 2 |
| Jul 18 • 03:30 | Real Salt Lake | | - | | Sporting Kansas City | 3 | : | 0 |
| Jul 18 • 03:30 | San Jose Earthquakes | | - | | Houston Dynamo | 1 | : | 2 |
| Jul 18 • 04:30 | Portland Timbers | | - | | Vancouver Whitecaps | 1 | : | 1 |
|
|
|
| Jul 24 • 01:00 | New York City FC | | - | | Inter Miami | 2 | : | 0 |
| Jul 24 • 01:30 | FC Cincinnati | | - | | Nashville SC | 1 | : | 1 |
| Jul 24 • 01:30 | Columbus Crew | | - | | New England Revolution | 0 | : | 0 |
| Jul 24 • 01:30 | Orlando City SC | | - | | Philadelphia Union | 0 | : | 1 |
| Jul 24 • 01:30 | Toronto FC | | - | | Charlotte FC | 4 | : | 0 |
| Jul 24 • 02:00 | Washington DC United | | - | | CF Montreal | 1 | : | 2 |
| Jul 24 • 02:30 | Houston Dynamo | | - | | Minnesota United | 1 | : | 2 |
| Jul 24 • 02:30 | Sporting Kansas City | | - | | Los Angeles FC | 0 | : | 2 |
| Jul 24 • 04:00 | Real Salt Lake | | - | | FC Dallas | 0 | : | 1 |
| Jul 24 • 04:00 | Seattle Sounders | | - | | Colorado Rapids | 2 | : | 1 |
| Jul 24 • 04:00 | Vancouver Whitecaps | | - | | Chicago Fire | 1 | : | 3 |
| Jul 24 • 04:30 | Portland Timbers | | - | | San Jose Earthquakes | 2 | : | 1 |
| Jul 25 • 02:00 | Austin FC | | - | | New York Red Bulls | 3 | : | 4 |
| Jul 25 • 03:30 | Los Angeles Galaxy | | - | | Atlanta United | 2 | : | 0 |
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| Jul 30 • 05:00 | Los Angeles FC | | - | | Seattle Sounders | 2 | : | 1 |
| Jul 30 • 21:00 | Minnesota United | | - | | Portland Timbers | 4 | : | 4 |
| Jul 30 • 23:00 | Chicago Fire | | - | | Atlanta United | 0 | : | 0 |
| Jul 31 • 01:30 | CF Montreal | | - | | New York City FC | 0 | : | 0 |
| Jul 31 • 01:30 | Philadelphia Union | | - | | Houston Dynamo | 6 | : | 0 |
| Jul 31 • 02:00 | Inter Miami | | - | | FC Cincinnati | 4 | : | 4 |
| Jul 31 • 02:00 | Nashville SC | | - | | Vancouver Whitecaps | 1 | : | 1 |
| Jul 31 • 02:00 | New England Revolution | | - | | Toronto FC | 0 | : | 0 |
| Jul 31 • 02:30 | Sporting Kansas City | | - | | Austin FC | 0 | : | 2 |
| Jul 31 • 03:00 | FC Dallas | | - | | Los Angeles Galaxy | 1 | : | 0 |
| Jul 31 • 04:00 | San Jose Earthquakes | | - | | Real Salt Lake | 2 | : | 2 |
| Jul 31 • 23:00 | Washington DC United | | - | | Orlando City SC | 2 | : | 1 |
| Aug 03 • 01:30 | New York Red Bulls | | - | | Colorado Rapids | 4 | : | 5 |
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| Aug 03 • 04:00 | Seattle Sounders | | - | | FC Dallas | 1 | : | 0 |
| Aug 04 • 01:00 | Charlotte FC | | - | | Washington DC United | 3 | : | 0 |
| Aug 04 • 01:30 | Columbus Crew | | - | | CF Montreal | 1 | : | 2 |
| Aug 04 • 04:30 | Portland Timbers | | - | | Nashville SC | 1 | : | 1 |
| Aug 04 • 04:30 | San Jose Earthquakes | | - | | Inter Miami | 0 | : | 1 |
| Aug 06 • 04:30 | Vancouver Whitecaps | | - | | Houston Dynamo | 2 | : | 1 |
| Aug 06 • 21:00 | Atlanta United | | - | | Seattle Sounders | 2 | : | 1 |
| Aug 07 • 01:00 | Charlotte FC | | - | | Chicago Fire | 2 | : | 3 |
| Aug 07 • 01:30 | FC Cincinnati | | - | | Philadelphia Union | 3 | : | 1 |
| Aug 07 • 01:30 | Columbus Crew | | - | | New York City FC | 3 | : | 2 |
| Aug 07 • 01:30 | Washington DC United | | - | | New York Red Bulls | 0 | : | 0 |
| Aug 07 • 01:30 | CF Montreal | | - | | Inter Miami | 2 | : | 2 |
| Aug 07 • 01:30 | Orlando City SC | | - | | New England Revolution | 0 | : | 3 |
| Aug 07 • 02:00 | Nashville SC | | - | | Toronto FC | 3 | : | 4 |
| Aug 07 • 02:30 | Sporting Kansas City | | - | | Los Angeles Galaxy | 4 | : | 2 |
| Aug 07 • 03:00 | Austin FC | | - | | San Jose Earthquakes | 3 | : | 3 |
| Aug 07 • 03:00 | Colorado Rapids | | - | | Minnesota United | 4 | : | 3 |
| Aug 07 • 04:00 | Real Salt Lake | | - | | Los Angeles FC | 1 | : | 4 |
| Aug 07 • 04:30 | Portland Timbers | | - | | FC Dallas | 1 | : | 1 |
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| Aug 14 • 00:00 | New York Red Bulls | | - | | Orlando City SC | 0 | : | 1 |
| Aug 14 • 01:30 | FC Cincinnati | | - | | Atlanta United | 2 | : | 2 |
| Aug 14 • 01:30 | New England Revolution | | - | | Washington DC United | 1 | : | 0 |
| Aug 14 • 01:30 | Philadelphia Union | | - | | Chicago Fire | 4 | : | 1 |
| Aug 14 • 01:30 | Toronto FC | | - | | Portland Timbers | 3 | : | 1 |
| Aug 14 • 02:00 | Inter Miami | | - | | New York City FC | 3 | : | 2 |
| Aug 14 • 03:00 | Austin FC | | - | | Sporting Kansas City | 4 | : | 3 |
| Aug 14 • 03:00 | Colorado Rapids | | - | | Columbus Crew | 1 | : | 1 |
| Aug 14 • 03:00 | FC Dallas | | - | | San Jose Earthquakes | 4 | : | 1 |
| Aug 14 • 03:00 | Houston Dynamo | | - | | CF Montreal | 2 | : | 3 |
| Aug 14 • 04:00 | Los Angeles Galaxy | | - | | Vancouver Whitecaps | 5 | : | 2 |
| Aug 14 • 04:30 | Los Angeles FC | | - | | Charlotte FC | 5 | : | 0 |
| Aug 15 • 03:00 | Nashville SC | | - | | Minnesota United | 1 | : | 2 |
| Aug 15 • 04:00 | Seattle Sounders | | - | | Real Salt Lake | 1 | : | 2 |
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| Aug 17 • 04:30 | Los Angeles FC | | - | | Washington DC United | 1 | : | 0 |
| Aug 18 • 01:30 | Atlanta United | | - | | New York Red Bulls | 1 | : | 2 |
| Aug 18 • 01:30 | Toronto FC | | - | | New England Revolution | 2 | : | 2 |
| Aug 18 • 02:00 | New York City FC | | - | | Charlotte FC | 1 | : | 3 |
| Aug 18 • 03:00 | FC Dallas | | - | | Philadelphia Union | 1 | : | 0 |
| Aug 18 • 04:00 | Vancouver Whitecaps | | - | | Colorado Rapids | 2 | : | 1 |
| Aug 20 • 04:00 | Los Angeles Galaxy | | - | | Seattle Sounders | 3 | : | 3 |
| Aug 21 • 00:00 | New York Red Bulls | | - | | FC Cincinnati | 1 | : | 1 |
| Aug 21 • 01:30 | Washington DC United | | - | | Philadelphia Union | 0 | : | 6 |
| Aug 21 • 01:30 | CF Montreal | | - | | New England Revolution | 4 | : | 0 |
| Aug 21 • 02:00 | Minnesota United | | - | | Austin FC | 2 | : | 1 |
| Aug 21 • 02:00 | Inter Miami | | - | | Toronto FC | 2 | : | 1 |
| Aug 21 • 03:00 | Colorado Rapids | | - | | Houston Dynamo | 1 | : | 1 |
| Aug 21 • 04:00 | Real Salt Lake | | - | | Vancouver Whitecaps | 1 | : | 1 |
| Aug 21 • 04:00 | San Jose Earthquakes | | - | | Los Angeles FC | 2 | : | 1 |
| Aug 21 • 23:30 | Columbus Crew | | - | | Atlanta United | 2 | : | 2 |
| Aug 22 • 00:00 | Chicago Fire | | - | | New York City FC | 0 | : | 2 |
| Aug 22 • 01:00 | Charlotte FC | | - | | Orlando City SC | 1 | : | 2 |
| Aug 22 • 01:30 | Sporting Kansas City | | - | | Portland Timbers | 4 | : | 1 |
| Aug 22 • 02:30 | Nashville SC | | - | | FC Dallas | 4 | : | 0 |
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| Aug 27 • 02:00 | Austin FC | | - | | Los Angeles FC | 4 | : | 1 |
| Aug 27 • 04:00 | Portland Timbers | | - | | Seattle Sounders | 2 | : | 1 |
| Aug 27 • 21:30 | Minnesota United | | - | | Houston Dynamo | 2 | : | 1 |
| Aug 28 • 01:00 | New York Red Bulls | | - | | Inter Miami | 3 | : | 1 |
| Aug 28 • 01:00 | Charlotte FC | | - | | Toronto FC | 0 | : | 2 |
| Aug 28 • 01:30 | FC Cincinnati | | - | | Columbus Crew | 2 | : | 2 |
| Aug 28 • 01:30 | Philadelphia Union | | - | | Colorado Rapids | 6 | : | 0 |
| Aug 28 • 02:00 | Chicago Fire | | - | | CF Montreal | 0 | : | 2 |
| Aug 28 • 02:30 | Sporting Kansas City | | - | | San Jose Earthquakes | 1 | : | 0 |
| Aug 28 • 03:00 | FC Dallas | | - | | Real Salt Lake | 1 | : | 1 |
| Aug 28 • 04:00 | Vancouver Whitecaps | | - | | Nashville SC | 0 | : | 3 |
| Aug 28 • 22:00 | Atlanta United | | - | | Washington DC United | 3 | : | 2 |
| Aug 29 • 01:30 | Orlando City SC | | - | | New York City FC | 2 | : | 1 |
| Aug 29 • 02:00 | New England Revolution | | - | | Los Angeles Galaxy | 1 | : | 2 |
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| Sep 01 • 01:00 | Philadelphia Union | | - | | Atlanta United | 4 | : | 1 |
| Sep 01 • 01:30 | Columbus Crew | | - | | Inter Miami | 1 | : | 0 |
| Sep 01 • 01:30 | CF Montreal | | - | | New York Red Bulls | 0 | : | 1 |
| Sep 01 • 01:30 | New England Revolution | | - | | Chicago Fire | 0 | : | 0 |
| Sep 01 • 01:30 | Orlando City SC | | - | | Seattle Sounders | 3 | : | 2 |
| Sep 01 • 01:30 | Toronto FC | | - | | Los Angeles Galaxy | 2 | : | 2 |
| Sep 01 • 02:00 | New York City FC | | - | | Washington DC United | 1 | : | 2 |
| Sep 01 • 02:30 | Houston Dynamo | | - | | Los Angeles FC | 2 | : | 1 |
| Sep 01 • 02:30 | Nashville SC | | - | | Colorado Rapids | 4 | : | 1 |
| Sep 01 • 03:00 | Austin FC | | - | | Portland Timbers | 1 | : | 2 |
| Sep 01 • 03:30 | Real Salt Lake | | - | | Minnesota United | 3 | : | 0 |
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| Sep 03 • 21:30 | Minnesota United | | - | | FC Dallas | 0 | : | 3 |
| Sep 03 • 23:30 | Columbus Crew | | - | | Chicago Fire | 0 | : | 0 |
| Sep 04 • 01:00 | New York Red Bulls | | - | | Philadelphia Union | 0 | : | 2 |
| Sep 04 • 01:30 | FC Cincinnati | | - | | Charlotte FC | 2 | : | 0 |
| Sep 04 • 02:30 | Nashville SC | | - | | Austin FC | 3 | : | 0 |
| Sep 04 • 23:30 | Portland Timbers | | - | | Atlanta United | 2 | : | 1 |
| Sep 05 • 01:30 | Washington DC United | | - | | Colorado Rapids | 0 | : | 0 |
| Sep 05 • 01:30 | Toronto FC | | - | | CF Montreal | 3 | : | 4 |
| Sep 05 • 02:00 | New England Revolution | | - | | New York City FC | 3 | : | 0 |
| Sep 05 • 02:00 | Los Angeles Galaxy | | - | | Sporting Kansas City | 2 | : | 2 |
| Sep 05 • 03:00 | Seattle Sounders | | - | | Houston Dynamo | 2 | : | 1 |
| Sep 05 • 03:30 | San Jose Earthquakes | | - | | Vancouver Whitecaps | 2 | : | 0 |
| Sep 05 • 04:30 | Los Angeles FC | | - | | Real Salt Lake | 2 | : | 0 |
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| Sep 08 • 02:00 | New York City FC | | - | | FC Cincinnati | 1 | : | 1 |
| Sep 10 • 01:30 | CF Montreal | | - | | Columbus Crew | 2 | : | 2 |
| Sep 10 • 19:00 | Charlotte FC | | - | | New York City FC | 1 | : | 0 |
| Sep 10 • 21:30 | Nashville SC | | - | | Los Angeles Galaxy | 1 | : | 1 |
| Sep 11 • 00:00 | New York Red Bulls | | - | | New England Revolution | 2 | : | 1 |
| Sep 11 • 01:30 | Atlanta United | | - | | Toronto FC | 4 | : | 2 |
| Sep 11 • 01:30 | FC Cincinnati | | - | | San Jose Earthquakes | 6 | : | 0 |
| Sep 11 • 01:30 | Philadelphia Union | | - | | Orlando City SC | 5 | : | 1 |
| Sep 11 • 02:00 | Chicago Fire | | - | | Inter Miami | 3 | : | 1 |
| Sep 11 • 02:00 | Seattle Sounders | | - | | Austin FC | 3 | : | 0 |
| Sep 11 • 02:30 | FC Dallas | | - | | Los Angeles FC | 2 | : | 1 |
| Sep 11 • 02:30 | Houston Dynamo | | - | | Sporting Kansas City | 0 | : | 0 |
| Sep 11 • 03:30 | Colorado Rapids | | - | | Vancouver Whitecaps | 3 | : | 1 |
| Sep 11 • 03:30 | Real Salt Lake | | - | | Washington DC United | 0 | : | 0 |
| Sep 11 • 04:00 | Portland Timbers | | - | | Minnesota United | 1 | : | 0 |
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| Sep 14 • 01:30 | CF Montreal | | - | | Chicago Fire | 3 | : | 2 |
| Sep 14 • 02:00 | Inter Miami | | - | | Columbus Crew | 2 | : | 1 |
| Sep 14 • 02:00 | Minnesota United | | - | | Los Angeles FC | 1 | : | 1 |
| Sep 14 • 02:30 | Houston Dynamo | | - | | New England Revolution | 3 | : | 1 |
| Sep 14 • 02:30 | Sporting Kansas City | | - | | Washington DC United | 3 | : | 0 |
| Sep 15 • 00:00 | Orlando City SC | | - | | Atlanta United | 0 | : | 1 |
| Sep 15 • 03:15 | Austin FC | | - | | Real Salt Lake | 3 | : | 0 |
| Sep 15 • 04:00 | Colorado Rapids | | - | | San Jose Earthquakes | 2 | : | 1 |
| Sep 15 • 04:00 | Vancouver Whitecaps | | - | | Los Angeles Galaxy | 3 | : | 0 |
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| Sep 17 • 19:00 | New York City FC | | - | | New York Red Bulls | 2 | : | 0 |
| Sep 17 • 21:30 | Atlanta United | | - | | Philadelphia Union | 0 | : | 0 |
| Sep 18 • 01:30 | New England Revolution | | - | | CF Montreal | 0 | : | 1 |
| Sep 18 • 01:30 | Orlando City SC | | - | | Toronto FC | 4 | : | 0 |
| Sep 18 • 02:00 | Chicago Fire | | - | | Charlotte FC | 2 | : | 3 |
| Sep 18 • 02:30 | Sporting Kansas City | | - | | Minnesota United | 4 | : | 1 |
| Sep 18 • 03:00 | Austin FC | | - | | Nashville SC | 1 | : | 1 |
| Sep 18 • 03:30 | Real Salt Lake | | - | | FC Cincinnati | 1 | : | 2 |
| Sep 18 • 04:00 | Vancouver Whitecaps | | - | | Seattle Sounders | 2 | : | 1 |
| Sep 18 • 04:30 | San Jose Earthquakes | | - | | FC Dallas | 1 | : | 1 |
| Sep 18 • 04:30 | Los Angeles Galaxy | | - | | Colorado Rapids | 4 | : | 1 |
| Sep 18 • 19:00 | Columbus Crew | | - | | Portland Timbers | 1 | : | 1 |
| Sep 18 • 23:00 | Washington DC United | | - | | Inter Miami | 2 | : | 3 |
| Sep 19 • 04:30 | Los Angeles FC | | - | | Houston Dynamo | 3 | : | 1 |
| Sep 25 • 04:00 | San Jose Earthquakes | | - | | Los Angeles Galaxy | 2 | : | 3 |
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| Sep 28 • 04:00 | Seattle Sounders | | - | | FC Cincinnati | 1 | : | 1 |
| Oct 01 • 01:30 | Toronto FC | | - | | Inter Miami | 0 | : | 1 |
| Oct 01 • 19:30 | New England Revolution | | - | | Atlanta United | 2 | : | 1 |
| Oct 01 • 21:30 | Colorado Rapids | | - | | FC Dallas | 1 | : | 0 |
| Oct 01 • 23:30 | Charlotte FC | | - | | Philadelphia Union | 4 | : | 0 |
| Oct 02 • 01:30 | FC Cincinnati | | - | | Chicago Fire | 2 | : | 3 |
| Oct 02 • 01:30 | Columbus Crew | | - | | New York Red Bulls | 2 | : | 1 |
| Oct 02 • 01:30 | CF Montreal | | - | | Washington DC United | 1 | : | 0 |
| Oct 02 • 04:00 | San Jose Earthquakes | | - | | Minnesota United | 2 | : | 0 |
| Oct 02 • 04:00 | Vancouver Whitecaps | | - | | Austin FC | 2 | : | 0 |
| Oct 02 • 04:30 | Los Angeles Galaxy | | - | | Real Salt Lake | 1 | : | 1 |
| Oct 02 • 19:00 | New York City FC | | - | | Orlando City SC | 2 | : | 1 |
| Oct 02 • 21:00 | Portland Timbers | | - | | Los Angeles FC | 1 | : | 2 |
| Oct 02 • 23:00 | Sporting Kansas City | | - | | Seattle Sounders | 1 | : | 0 |
| Oct 03 • 02:30 | Nashville SC | | - | | Houston Dynamo | 1 | : | 2 |
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| Oct 06 • 01:00 | Charlotte FC | | - | | Columbus Crew | 2 | : | 2 |
| Oct 06 • 02:00 | Inter Miami | | - | | Orlando City SC | 4 | : | 1 |
| Oct 09 • 20:30 | Atlanta United | | - | | New York City FC | 1 | : | 2 |
| Oct 09 • 20:30 | Chicago Fire | | - | | New England Revolution | 1 | : | 1 |
| Oct 09 • 20:30 | Washington DC United | | - | | FC Cincinnati | 2 | : | 5 |
| Oct 09 • 20:30 | Inter Miami | | - | | CF Montreal | 1 | : | 3 |
| Oct 09 • 20:30 | New York Red Bulls | | - | | Charlotte FC | 2 | : | 0 |
| Oct 09 • 20:30 | Orlando City SC | | - | | Columbus Crew | 2 | : | 1 |
| Oct 09 • 20:30 | Philadelphia Union | | - | | Toronto FC | 4 | : | 0 |
| Oct 09 • 23:00 | Austin FC | | - | | Colorado Rapids | 1 | : | 1 |
| Oct 09 • 23:00 | FC Dallas | | - | | Sporting Kansas City | 2 | : | 1 |
| Oct 09 • 23:00 | Houston Dynamo | | - | | Los Angeles Galaxy | 1 | : | 3 |
| Oct 09 • 23:00 | Los Angeles FC | | - | | Nashville SC | 0 | : | 1 |
| Oct 09 • 23:00 | Minnesota United | | - | | Vancouver Whitecaps | 2 | : | 0 |
| Oct 09 • 23:00 | Real Salt Lake | | - | | Portland Timbers | 3 | : | 1 |
| Oct 09 • 23:00 | Seattle Sounders | | - | | San Jose Earthquakes | 2 | : | 2 |
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| Oct 15 • 18:00 | New York Red Bulls | | - | | FC Cincinnati | 1 | : | 2 |
| Oct 15 • 21:00 | Los Angeles Galaxy | | - | | Nashville SC | 1 | : | 0 |
| Oct 16 • 21:00 | Austin FC | | - | | Real Salt Lake | 2 | : | 2 |
| Oct 17 • 02:00 | CF Montreal | | - | | Orlando City SC | 2 | : | 0 |
| Oct 18 • 01:00 | New York City FC | | - | | Inter Miami | 3 | : | 0 |
| Oct 18 • 03:30 | FC Dallas | | - | | Minnesota United | 1 | : | 1 |
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| Oct 21 • 02:00 | Philadelphia Union | | - | | FC Cincinnati | 1 | : | 0 |
| Oct 21 • 04:00 | Los Angeles FC | | - | | Los Angeles Galaxy | 3 | : | 2 |
| Oct 23 • 19:00 | CF Montreal | | - | | New York City FC | 1 | : | 3 |
| Oct 24 • 02:00 | Austin FC | | - | | FC Dallas | 2 | : | 1 |
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| Oct 30 • 20:00 | Los Angeles FC | | - | | Austin FC | 3 | : | 0 |
| Oct 31 • 01:00 | Philadelphia Union | | - | | New York City FC | 3 | : | 1 |
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| Nov 05 • 21:00 | Los Angeles FC | | - | | Philadelphia Union | 3 | : | 3 |
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