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| Feb 02 • 23:30 | CA Huracán |  | - |  | Caracas FC | 1 | : | 0 |
| Feb 03 • 00:45 | CA River Plate |  | - |  | Universidad de Chile | 2 | : | 0 |
| Feb 04 • 00:45 | Universidad César Vallejo |  | - |  | São Paulo FC | 1 | : | 1 |
| Feb 04 • 03:15 | Club Puebla |  | - |  | Racing Club | 2 | : | 2 |
| Feb 04 • 23:30 | Independiente del Valle |  | - |  | Club Guaraní | 1 | : | 0 |
| Feb 05 • 01:45 | Oriente Petrolero |  | - |  | Independiente Santa Fe | 1 | : | 3 |
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| Feb 09 • 23:30 | Universidad de Chile | | - | | CA River Plate | 0 | : | 0 |
| Feb 10 • 01:45 | Caracas FC | | - | | CA Huracán | 2 | : | 1 |
| Feb 11 • 00:45 | São Paulo FC | | - | | Universidad César Vallejo | 1 | : | 0 |
| Feb 11 • 01:45 | Racing Club | | - | | Club Puebla | 1 | : | 0 |
| Feb 11 • 23:30 | Club Guaraní | | - | | Independiente del Valle | 2 | : | 1 |
| Feb 12 • 01:45 | Independiente Santa Fe | | - | | Oriente Petrolero | 3 | : | 0 |
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| Group B |
Feb 17 • 00:45 | CA River Plate | | - |  | SE Palmeiras | 2 | : | 2 |
| Group G |
Feb 17 • 03:00 | Deportivo Táchira |  | - |  | Olimpia Asunción | 2 | : | 1 |
| Group H |
Feb 17 • 03:00 | Independiente Santa Fe | | - |  | Cerro Porteño | 0 | : | 0 |
| Group A |
Feb 17 • 22:30 | São Paulo FC | | - |  | The Strongest | 0 | : | 1 |
| Group E |
Feb 18 • 00:45 | FBC Melgar |  | - |  | Atlético Mineiro | 1 | : | 2 |
| Group H |
Feb 18 • 00:45 | CD Cobresal |  | - |  | Corinthians | 0 | : | 1 |
| Group F |
Feb 18 • 03:00 | Deportivo Toluca |  | - |  | Grêmio Porto Alegrense | 2 | : | 0 |
| Group D |
Feb 19 • 01:45 | Sporting Cristal |  | - |  | CA Peñarol | 1 | : | 1 |
| Group E |
Feb 19 • 01:45 | Independiente del Valle | | - |  | Colo-Colo | 1 | : | 1 |
| Group G |
Feb 19 • 04:00 | Pumas UNAM |  | - |  | CS Emelec | 4 | : | 2 |
| Group F |
Feb 23 • 23:30 | LDU Quito |  | - |  | San Lorenzo | 2 | : | 0 |
| Group D |
Feb 24 • 01:45 | CA Huracán | | - |  | Atlético Nacional | 0 | : | 2 |
| Group C |
Feb 24 • 23:30 | Racing Club | | - |  | Club Bolívar | 4 | : | 1 |
| Group C |
Feb 25 • 01:45 | Deportivo Cali |  | - |  | Boca Juniors | 0 | : | 0 |
| Group B |
Feb 25 • 23:30 | Rosario Central |  | - |  | Club Nacional Montevideo | 1 | : | 1 |
| Group A |
Feb 26 • 01:45 | Trujillanos FC |  | - |  | River Plate | 0 | : | 4 |
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| Group E |
Feb 24 • 23:30 | Colo-Colo | | - | | FBC Melgar | 1 | : | 0 |
| Group E |
Feb 25 • 01:45 | Atlético Mineiro | | - | | Independiente del Valle | 1 | : | 0 |
| Group H |
Feb 25 • 23:30 | Cerro Porteño | | - | | CD Cobresal | 2 | : | 1 |
| Group G |
Feb 26 • 01:45 | CS Emelec | | - | | Deportivo Táchira | 2 | : | 0 |
| Group G |
Mar 01 • 23:30 | Olimpia Asunción | | - | | Pumas UNAM | 0 | : | 2 |
| Group D |
Mar 02 • 01:45 | CA Peñarol | | - | | CA Huracán | 0 | : | 1 |
| Group D |
Mar 02 • 01:45 | Atlético Nacional | | - | | Sporting Cristal | 3 | : | 0 |
| Group A |
Mar 02 • 21:15 | The Strongest | | - | | Trujillanos FC | 2 | : | 1 |
| Group B |
Mar 02 • 23:30 | Club Nacional Montevideo | | - | | CA River Plate | 0 | : | 0 |
| Group F |
Mar 02 • 23:30 | San Lorenzo | | - | | Deportivo Toluca | 1 | : | 1 |
| Group F |
Mar 03 • 01:45 | Grêmio Porto Alegrense | | - | | LDU Quito | 4 | : | 0 |
| Group H |
Mar 03 • 01:45 | Corinthians | | - | | Independiente Santa Fe | 1 | : | 0 |
| Group C |
Mar 03 • 23:30 | Boca Juniors | | - | | Racing Club | 0 | : | 0 |
| Group B |
Mar 04 • 01:45 | SE Palmeiras | | - | | Rosario Central | 2 | : | 0 |
| Group C |
Mar 04 • 01:45 | Club Bolívar | | - | | Deportivo Cali | 5 | : | 0 |
| Group A |
Mar 10 • 23:30 | River Plate | | - | | São Paulo FC | 1 | : | 1 |
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| Group E |
Mar 01 • 21:15 | FBC Melgar | | - | | Independiente del Valle | 0 | : | 1 |
| Group G |
Mar 08 • 23:30 | CS Emelec | | - | | Olimpia Asunción | 2 | : | 2 |
| Group D |
Mar 09 • 01:45 | Atlético Nacional | | - | | CA Peñarol | 2 | : | 0 |
| Group D |
Mar 09 • 01:45 | Sporting Cristal | | - | | CA Huracán | 3 | : | 2 |
| Group H |
Mar 09 • 21:15 | CD Cobresal | | - | | Independiente Santa Fe | 1 | : | 2 |
| Group B |
Mar 09 • 23:30 | Rosario Central | | - | | CA River Plate | 4 | : | 1 |
| Group H |
Mar 09 • 23:30 | Cerro Porteño | | - | | Corinthians | 3 | : | 2 |
| Group B |
Mar 10 • 01:45 | SE Palmeiras | | - | | Club Nacional Montevideo | 1 | : | 2 |
| Group F |
Mar 10 • 01:45 | Grêmio Porto Alegrense | | - | | San Lorenzo | 1 | : | 1 |
| Group G |
Mar 10 • 01:45 | Deportivo Táchira | | - | | Pumas UNAM | 2 | : | 0 |
| Group C |
Mar 11 • 01:45 | Club Bolívar | | - | | Boca Juniors | 1 | : | 1 |
| Group E |
Mar 11 • 01:45 | Colo-Colo | | - | | Atlético Mineiro | 0 | : | 0 |
| Group F |
Mar 11 • 01:45 | LDU Quito | | - | | Deportivo Toluca | 1 | : | 2 |
| Group A |
Mar 16 • 23:30 | The Strongest | | - | | River Plate | 1 | : | 1 |
| Group A |
Mar 16 • 23:30 | Trujillanos FC | | - | | São Paulo FC | 1 | : | 1 |
| Group C |
Mar 18 • 01:45 | Deportivo Cali | | - | | Racing Club | 2 | : | 2 |
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| Group E |
Mar 15 • 23:30 | Independiente del Valle | | - | | FBC Melgar | 2 | : | 0 |
| Group H |
Mar 15 • 23:30 | Independiente Santa Fe | | - | | CD Cobresal | 3 | : | 0 |
| Group D |
Mar 16 • 01:45 | CA Peñarol | | - | | Atlético Nacional | 0 | : | 4 |
| Group F |
Mar 16 • 01:45 | San Lorenzo | | - | | Grêmio Porto Alegrense | 1 | : | 1 |
| Group E |
Mar 17 • 01:45 | Atlético Mineiro | | - | | Colo-Colo | 3 | : | 0 |
| Group H |
Mar 17 • 01:45 | Corinthians | | - | | Cerro Porteño | 2 | : | 0 |
| Group B |
Mar 17 • 23:30 | CA River Plate | | - | | Rosario Central | 1 | : | 3 |
| Group G |
Mar 17 • 23:30 | Olimpia Asunción | | - | | CS Emelec | 4 | : | 2 |
| Group B |
Mar 18 • 01:45 | Club Nacional Montevideo | | - | | SE Palmeiras | 1 | : | 0 |
| Group G |
Mar 18 • 04:00 | Pumas UNAM | | - | | Deportivo Táchira | 4 | : | 1 |
| Group D |
Apr 06 • 00:30 | CA Huracán | | - | | Sporting Cristal | 4 | : | 2 |
| Group A |
Apr 06 • 02:45 | São Paulo FC | | - | | Trujillanos FC | 6 | : | 0 |
| Group F |
Apr 06 • 02:45 | Deportivo Toluca | | - | | LDU Quito | 2 | : | 1 |
| Group A |
Apr 07 • 00:30 | River Plate | | - | | The Strongest | 6 | : | 0 |
| Group C |
Apr 08 • 00:30 | Boca Juniors | | - | | Club Bolívar | 3 | : | 1 |
| Group C |
Apr 08 • 02:45 | Racing Club | | - | | Deportivo Cali | 4 | : | 2 |
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| Group G |
Apr 06 • 00:30 | Deportivo Táchira | | - | | CS Emelec | 1 | : | 0 |
| Group B |
Apr 07 • 02:45 | Rosario Central | | - | | SE Palmeiras | 3 | : | 3 |
| Group E |
Apr 07 • 02:45 | Independiente del Valle | | - | | Atlético Mineiro | 3 | : | 2 |
| Group H |
Apr 07 • 02:45 | Independiente Santa Fe | | - | | Corinthians | 1 | : | 1 |
| Group G |
Apr 07 • 05:00 | Pumas UNAM | | - | | Olimpia Asunción | 4 | : | 1 |
| Group B |
Apr 08 • 00:30 | CA River Plate | | - | | Club Nacional Montevideo | 2 | : | 2 |
| Group E |
Apr 08 • 02:45 | FBC Melgar | | - | | Colo-Colo | 1 | : | 2 |
| Group A |
Apr 13 • 00:30 | Trujillanos FC | | - | | The Strongest | 2 | : | 1 |
| Group D |
Apr 13 • 00:30 | CA Huracán | | - | | CA Peñarol | 0 | : | 0 |
| Group D |
Apr 13 • 02:45 | Sporting Cristal | | - | | Atlético Nacional | 0 | : | 1 |
| Group F |
Apr 13 • 02:45 | Deportivo Toluca | | - | | San Lorenzo | 2 | : | 1 |
| Group H |
Apr 13 • 22:15 | CD Cobresal | | - | | Cerro Porteño | 2 | : | 0 |
| Group C |
Apr 14 • 00:30 | Racing Club | | - | | Boca Juniors | 0 | : | 1 |
| Group A |
Apr 14 • 02:45 | São Paulo FC | | - | | River Plate | 2 | : | 1 |
| Group F |
Apr 14 • 02:45 | LDU Quito | | - | | Grêmio Porto Alegrense | 2 | : | 3 |
| Group C |
Apr 15 • 02:45 | Deportivo Cali | | - | | Club Bolívar | 1 | : | 1 |
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| Group G |
Apr 14 • 00:30 | Olimpia Asunción | | - | | Deportivo Táchira | 4 | : | 0 |
| Group G |
Apr 14 • 00:30 | CS Emelec | | - | | Pumas UNAM | 2 | : | 3 |
| Group E |
Apr 15 • 00:30 | Atlético Mineiro | | - | | FBC Melgar | 4 | : | 0 |
| Group E |
Apr 15 • 00:30 | Colo-Colo | | - | | Independiente del Valle | 0 | : | 0 |
| Group B |
Apr 15 • 02:45 | Club Nacional Montevideo | | - | | Rosario Central | 0 | : | 2 |
| Group B |
Apr 15 • 02:45 | SE Palmeiras | | - | | CA River Plate | 4 | : | 0 |
| Group D |
Apr 20 • 00:30 | CA Peñarol | | - | | Sporting Cristal | 4 | : | 3 |
| Group D |
Apr 20 • 00:30 | Atlético Nacional | | - | | CA Huracán | 0 | : | 0 |
| Group F |
Apr 20 • 02:45 | San Lorenzo | | - | | LDU Quito | 1 | : | 1 |
| Group F |
Apr 20 • 02:45 | Grêmio Porto Alegrense | | - | | Deportivo Toluca | 1 | : | 0 |
| Group C |
Apr 21 • 00:30 | Boca Juniors | | - | | Deportivo Cali | 6 | : | 2 |
| Group C |
Apr 21 • 00:30 | Club Bolívar | | - | | Racing Club | 1 | : | 1 |
| Group H |
Apr 21 • 02:45 | Corinthians | | - | | CD Cobresal | 6 | : | 0 |
| Group H |
Apr 21 • 02:45 | Cerro Porteño | | - | | Independiente Santa Fe | 1 | : | 0 |
| Group A |
Apr 22 • 02:45 | River Plate | | - | | Trujillanos FC | 4 | : | 3 |
| Group A |
Apr 22 • 02:45 | The Strongest | | - | | São Paulo FC | 1 | : | 1 |
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| Apr 27 • 00:30 | CA Huracán | | - | | Atlético Nacional | 0 | : | 0 |
| Apr 27 • 02:45 | Deportivo Táchira | | - | | Pumas UNAM | 1 | : | 0 |
| Apr 28 • 00:30 | Racing Club | | - | | Atlético Mineiro | 0 | : | 0 |
| Apr 28 • 02:45 | Grêmio Porto Alegrense | | - | | Rosario Central | 0 | : | 1 |
| Apr 28 • 02:45 | Club Nacional Montevideo | | - | | Corinthians | 0 | : | 0 |
| Apr 29 • 00:30 | Independiente del Valle | | - | | River Plate | 2 | : | 0 |
| Apr 29 • 02:45 | São Paulo FC | | - | | Deportivo Toluca | 4 | : | 0 |
| Apr 29 • 02:45 | Cerro Porteño | | - | | Boca Juniors | 1 | : | 2 |
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| May 04 • 02:45 | Atlético Nacional | | - | | CA Huracán | 4 | : | 2 |
| May 04 • 04:45 | Pumas UNAM | | - | | Deportivo Táchira | 2 | : | 0 |
| May 05 • 00:15 | Deportivo Toluca | | - | | São Paulo FC | 3 | : | 1 |
| May 05 • 00:15 | River Plate | | - | | Independiente del Valle | 1 | : | 0 |
| May 05 • 02:45 | Atlético Mineiro | | - | | Racing Club | 2 | : | 1 |
| May 05 • 02:45 | Corinthians | | - | | Club Nacional Montevideo | 2 | : | 2 |
| May 06 • 00:15 | Rosario Central | | - | | Grêmio Porto Alegrense | 3 | : | 0 |
| May 06 • 02:45 | Boca Juniors | | - | | Cerro Porteño | 3 | : | 1 |
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| May 12 • 02:45 | São Paulo FC | | - | | Atlético Mineiro | 1 | : | 0 |
| May 13 • 00:30 | Club Nacional Montevideo | | - | | Boca Juniors | 1 | : | 1 |
| May 13 • 02:45 | Rosario Central | | - | | Atlético Nacional | 1 | : | 0 |
| May 18 • 02:45 | Independiente del Valle | | - | | Pumas UNAM | 2 | : | 1 |
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| May 19 • 02:45 | Atlético Mineiro | | - | | São Paulo FC | 2 | : | 1 |
| May 20 • 01:15 | Boca Juniors | | - | | Club Nacional Montevideo | 1 | : | 1 |
| May 20 • 03:45 | Atlético Nacional | | - | | Rosario Central | 3 | : | 1 |
| May 25 • 02:45 | Pumas UNAM | | - | | Independiente del Valle | 2 | : | 1 |
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| Jul 07 • 02:45 | São Paulo FC | | - | | Atlético Nacional | 0 | : | 2 |
| Jul 08 • 02:45 | Independiente del Valle | | - | | Boca Juniors | 2 | : | 1 |
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| Jul 14 • 02:45 | Atlético Nacional | | - | | São Paulo FC | 2 | : | 1 |
| Jul 15 • 02:45 | Boca Juniors | | - | | Independiente del Valle | 2 | : | 3 |
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| Jul 21 • 02:45 | Independiente del Valle | | - | | Atlético Nacional | 1 | : | 1 |
| Jul 28 • 02:45 | Atlético Nacional | | - | | Independiente del Valle | 1 | : | 0 |
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