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| Feb 16 • 00:45 | Botafogo |  | - |  | Olimpia Asunción | 1 | : | 0 |
| Feb 16 • 00:45 | Club Athletico Paranaense |  | - |  | Deportivo Capiatá | 3 | : | 3 |
| Feb 16 • 23:15 | Atlético Junior |  | - |  | Atlético Tucumán | 1 | : | 0 |
| Feb 17 • 01:00 | Unión Española |  | - |  | The Strongest | 1 | : | 1 |
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| Feb 23 • 01:45 | Deportivo Capiatá | | - | | Club Athletico Paranaense | 0 | : | 1 |
| Feb 23 • 01:45 | Olimpia Asunción | | - | | Botafogo | 1 | : | 0 |
| Feb 23 • 23:15 | Atlético Tucumán | | - | | Atlético Junior | 3 | : | 1 |
| Feb 24 • 01:00 | The Strongest | | - | | Unión Española | 5 | : | 0 |
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| Group H |
Mar 07 • 21:15 | Deportes Iquique |  | - |  | Club Guaraní | 0 | : | 1 |
| Group E |
Mar 07 • 23:30 | Club Jorge Wilstermann |  | - |  | CA Peñarol | 6 | : | 2 |
| Group D |
Mar 08 • 01:00 | Club Athletico Paranaense | | - |  | CD Universidad Católica | 2 | : | 2 |
| Group G |
Mar 08 • 01:45 | Zulia FC |  | - |  | Chapecoense | 1 | : | 2 |
| Group F |
Mar 08 • 23:30 | Sport Boys Warnes |  | - |  | Club Libertad | 3 | : | 3 |
| Group F |
Mar 08 • 23:30 | Godoy Cruz |  | - |  | Atlético Mineiro | 1 | : | 1 |
| Group D |
Mar 09 • 01:45 | Flamengo |  | - |  | San Lorenzo | 4 | : | 0 |
| Group E |
Mar 09 • 01:45 | Atlético Tucumán | | - |  | SE Palmeiras | 1 | : | 1 |
| Group H |
Mar 09 • 23:30 | Zamora FC |  | - |  | Grêmio Porto Alegrense | 0 | : | 2 |
| Group B |
Mar 10 • 01:00 | The Strongest | | - |  | Independiente Santa Fe | 2 | : | 0 |
| Group G |
Mar 10 • 01:00 | CA Lanús |  | - |  | Club Nacional Montevideo | 0 | : | 1 |
| Group B |
Mar 10 • 01:45 | Sporting Cristal |  | - |  | Santos FC | 1 | : | 1 |
| Group C |
Mar 14 • 23:30 | FBC Melgar |  | - |  | CS Emelec | 1 | : | 0 |
| Group A |
Mar 15 • 01:00 | Botafogo | | - |  | Estudiantes de La Plata | 2 | : | 1 |
| Group A |
Mar 15 • 01:45 | Barcelona SC |  | - |  | Atlético Nacional | 2 | : | 1 |
| Group C |
Mar 16 • 01:00 | Independiente Medellín |  | - |  | River Plate | 1 | : | 3 |
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| Group D |
Mar 15 • 23:30 | San Lorenzo | | - | | Club Athletico Paranaense | 0 | : | 1 |
| Group G |
Mar 15 • 23:30 | Club Nacional Montevideo | | - | | Zulia FC | 0 | : | 1 |
| Group D |
Mar 16 • 01:45 | CD Universidad Católica | | - | | Flamengo | 1 | : | 0 |
| Group E |
Mar 16 • 01:45 | SE Palmeiras | | - | | Club Jorge Wilstermann | 1 | : | 0 |
| Group G |
Mar 16 • 23:30 | Chapecoense | | - | | CA Lanús | 1 | : | 3 |
| Group E |
Mar 17 • 01:00 | CA Peñarol | | - | | Atlético Tucumán | 2 | : | 1 |
| Group B |
Mar 17 • 01:45 | Independiente Santa Fe | | - | | Sporting Cristal | 3 | : | 0 |
| Group B |
Mar 17 • 01:45 | Santos FC | | - | | The Strongest | 2 | : | 0 |
| Group F |
Apr 12 • 00:30 | Club Libertad | | - | | Godoy Cruz | 1 | : | 2 |
| Group A |
Apr 12 • 02:00 | Estudiantes de La Plata | | - | | Barcelona SC | 0 | : | 2 |
| Group H |
Apr 12 • 02:45 | Grêmio Porto Alegrense | | - | | Deportes Iquique | 3 | : | 2 |
| Group H |
Apr 13 • 00:30 | Club Guaraní | | - | | Zamora FC | 3 | : | 1 |
| Group C |
Apr 14 • 00:30 | CS Emelec | | - | | Independiente Medellín | 1 | : | 0 |
| Group F |
Apr 14 • 00:30 | Atlético Mineiro | | - | | Sport Boys Warnes | 5 | : | 2 |
| Group C |
Apr 14 • 02:00 | River Plate | | - | | FBC Melgar | 4 | : | 2 |
| Group A |
Apr 14 • 02:45 | Atlético Nacional | | - | | Botafogo | 0 | : | 2 |
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| Group E |
Apr 12 • 00:30 | Club Jorge Wilstermann | | - | | Atlético Tucumán | 2 | : | 1 |
| Group D |
Apr 13 • 02:00 | CD Universidad Católica | | - | | San Lorenzo | 1 | : | 1 |
| Group D |
Apr 13 • 02:45 | Flamengo | | - | | Club Athletico Paranaense | 2 | : | 1 |
| Group E |
Apr 13 • 02:45 | SE Palmeiras | | - | | CA Peñarol | 3 | : | 2 |
| Group G |
Apr 19 • 02:00 | CA Lanús | | - | | Zulia FC | 5 | : | 0 |
| Group B |
Apr 19 • 02:45 | Sporting Cristal | | - | | The Strongest | 0 | : | 0 |
| Group G |
Apr 19 • 02:45 | Chapecoense | | - | | Club Nacional Montevideo | 1 | : | 1 |
| Group A |
Apr 20 • 00:30 | Estudiantes de La Plata | | - | | Atlético Nacional | 1 | : | 0 |
| Group H |
Apr 20 • 02:00 | Zamora FC | | - | | Deportes Iquique | 1 | : | 4 |
| Group B |
Apr 20 • 02:45 | Independiente Santa Fe | | - | | Santos FC | 0 | : | 0 |
| Group F |
Apr 20 • 02:45 | Club Libertad | | - | | Atlético Mineiro | 1 | : | 0 |
| Group F |
Apr 21 • 00:30 | Godoy Cruz | | - | | Sport Boys Warnes | 2 | : | 0 |
| Group H |
Apr 21 • 00:30 | Club Guaraní | | - | | Grêmio Porto Alegrense | 1 | : | 1 |
| Group C |
Apr 21 • 02:00 | Independiente Medellín | | - | | FBC Melgar | 2 | : | 0 |
| Group A |
Apr 21 • 02:45 | Barcelona SC | | - | | Botafogo | 1 | : | 1 |
| Group C |
Apr 28 • 02:00 | CS Emelec | | - | | River Plate | 1 | : | 2 |
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| Group H |
Apr 25 • 22:15 | Deportes Iquique | | - | | Zamora FC | 4 | : | 3 |
| Group E |
Apr 26 • 00:30 | Atlético Tucumán | | - | | Club Jorge Wilstermann | 2 | : | 1 |
| Group D |
Apr 26 • 02:00 | San Lorenzo | | - | | CD Universidad Católica | 2 | : | 1 |
| Group F |
Apr 27 • 00:30 | Atlético Mineiro | | - | | Club Libertad | 2 | : | 0 |
| Group C |
Apr 27 • 02:00 | FBC Melgar | | - | | Independiente Medellín | 1 | : | 2 |
| Group D |
Apr 27 • 02:45 | Club Athletico Paranaense | | - | | Flamengo | 2 | : | 1 |
| Group E |
Apr 27 • 02:45 | CA Peñarol | | - | | SE Palmeiras | 2 | : | 3 |
| Group G |
Apr 28 • 00:30 | Club Nacional Montevideo | | - | | Chapecoense | 3 | : | 0 |
| Group G |
Apr 28 • 00:30 | Zulia FC | | - | | CA Lanús | 1 | : | 1 |
| Group F |
Apr 28 • 02:45 | Sport Boys Warnes | | - | | Godoy Cruz | 1 | : | 3 |
| Group H |
Apr 28 • 02:45 | Grêmio Porto Alegrense | | - | | Club Guaraní | 4 | : | 1 |
| Group A |
May 03 • 02:00 | Atlético Nacional | | - | | Estudiantes de La Plata | 4 | : | 1 |
| Group A |
May 03 • 02:45 | Botafogo | | - | | Barcelona SC | 0 | : | 2 |
| Group B |
May 05 • 00:30 | The Strongest | | - | | Sporting Cristal | 5 | : | 1 |
| Group B |
May 05 • 02:45 | Santos FC | | - | | Independiente Santa Fe | 3 | : | 2 |
| Group C |
May 11 • 00:15 | River Plate | | - | | CS Emelec | 1 | : | 1 |
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| Group E |
May 03 • 00:30 | Atlético Tucumán | | - | | CA Peñarol | 2 | : | 1 |
| Group F |
May 04 • 00:30 | Sport Boys Warnes | | - | | Atlético Mineiro | 1 | : | 5 |
| Group H |
May 04 • 00:30 | Deportes Iquique | | - | | Grêmio Porto Alegrense | 2 | : | 1 |
| Group D |
May 04 • 02:00 | Club Athletico Paranaense | | - | | San Lorenzo | 0 | : | 3 |
| Group D |
May 04 • 02:45 | Flamengo | | - | | CD Universidad Católica | 3 | : | 1 |
| Group E |
May 04 • 02:45 | Club Jorge Wilstermann | | - | | SE Palmeiras | 3 | : | 2 |
| Group F |
May 05 • 02:00 | Godoy Cruz | | - | | Club Libertad | 1 | : | 1 |
| Group H |
May 05 • 02:45 | Zamora FC | | - | | Club Guaraní | 1 | : | 3 |
| Group G |
May 17 • 00:30 | Zulia FC | | - | | Club Nacional Montevideo | 0 | : | 0 |
| Group C |
May 17 • 04:15 | Independiente Medellín | | - | | CS Emelec | 1 | : | 2 |
| Group B |
May 18 • 00:30 | Sporting Cristal | | - | | Independiente Santa Fe | 0 | : | 2 |
| Group B |
May 18 • 00:30 | The Strongest | | - | | Santos FC | 1 | : | 1 |
| Group G |
May 18 • 02:45 | CA Lanús | | - | | Chapecoense | 3 | : | 0 |
| Group A |
May 19 • 00:30 | Barcelona SC | | - | | Estudiantes de La Plata | 0 | : | 3 |
| Group C |
May 19 • 02:00 | FBC Melgar | | - | | River Plate | 2 | : | 3 |
| Group A |
May 19 • 02:45 | Botafogo | | - | | Atlético Nacional | 1 | : | 0 |
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| Group F |
May 17 • 02:00 | Club Libertad | | - | | Sport Boys Warnes | 1 | : | 1 |
| Group F |
May 17 • 02:00 | Atlético Mineiro | | - | | Godoy Cruz | 4 | : | 1 |
| Group D |
May 18 • 02:45 | San Lorenzo | | - | | Flamengo | 2 | : | 1 |
| Group D |
May 18 • 02:45 | CD Universidad Católica | | - | | Club Athletico Paranaense | 2 | : | 3 |
| Group G |
May 24 • 00:30 | Club Nacional Montevideo | | - | | CA Lanús | 0 | : | 1 |
| Group G |
May 24 • 00:30 | Chapecoense | | - | | Zulia FC | 2 | : | 1 |
| Group B |
May 24 • 02:45 | Independiente Santa Fe | | - | | The Strongest | 1 | : | 1 |
| Group B |
May 24 • 02:45 | Santos FC | | - | | Sporting Cristal | 4 | : | 0 |
| Group E |
May 25 • 02:45 | SE Palmeiras | | - | | Atlético Tucumán | 3 | : | 1 |
| Group E |
May 25 • 02:45 | CA Peñarol | | - | | Club Jorge Wilstermann | 2 | : | 0 |
| Group C |
May 26 • 00:30 | CS Emelec | | - | | FBC Melgar | 3 | : | 0 |
| Group C |
May 26 • 00:30 | River Plate | | - | | Independiente Medellín | 1 | : | 2 |
| Group A |
May 26 • 02:45 | Atlético Nacional | | - | | Barcelona SC | 3 | : | 1 |
| Group A |
May 26 • 02:45 | Estudiantes de La Plata | | - | | Botafogo | 1 | : | 0 |
| Group H |
May 26 • 02:45 | Grêmio Porto Alegrense | | - | | Zamora FC | 4 | : | 0 |
| Group H |
May 26 • 02:45 | Club Guaraní | | - | | Deportes Iquique | 0 | : | 0 |
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| Jul 05 • 00:15 | Godoy Cruz | | - | | Grêmio Porto Alegrense | 0 | : | 1 |
| Jul 05 • 02:45 | Club Guaraní | | - | | River Plate | 0 | : | 2 |
| Jul 06 • 00:15 | Club Athletico Paranaense | | - | | Santos FC | 2 | : | 3 |
| Jul 06 • 02:45 | Club Jorge Wilstermann | | - | | Atlético Mineiro | 1 | : | 0 |
| Jul 06 • 02:45 | Barcelona SC | | - | | SE Palmeiras | 1 | : | 0 |
| Jul 07 • 00:15 | The Strongest | | - | | CA Lanús | 1 | : | 1 |
| Jul 07 • 02:45 | CS Emelec | | - | | San Lorenzo | 0 | : | 1 |
| Jul 07 • 02:45 | Club Nacional Montevideo | | - | | Botafogo | 0 | : | 1 |
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| Aug 09 • 00:15 | CA Lanús | | - | | The Strongest | 1 | : | 0 |
| Aug 09 • 02:45 | River Plate | | - | | Club Guaraní | 1 | : | 1 |
| Aug 10 • 00:15 | Grêmio Porto Alegrense | | - | | Godoy Cruz | 2 | : | 1 |
| Aug 10 • 02:45 | Atlético Mineiro | | - | | Club Jorge Wilstermann | 0 | : | 0 |
| Aug 10 • 02:45 | SE Palmeiras | | - | | Barcelona SC | 1 | : | 0 |
| Aug 11 • 00:15 | Botafogo | | - | | Club Nacional Montevideo | 2 | : | 0 |
| Aug 11 • 02:45 | San Lorenzo | | - | | CS Emelec | 0 | : | 1 |
| Aug 11 • 02:45 | Santos FC | | - | | Club Athletico Paranaense | 1 | : | 0 |
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| Sep 14 • 00:15 | San Lorenzo | | - | | CA Lanús | 2 | : | 0 |
| Sep 14 • 02:45 | Barcelona SC | | - | | Santos FC | 1 | : | 1 |
| Sep 14 • 02:45 | Botafogo | | - | | Grêmio Porto Alegrense | 0 | : | 0 |
| Sep 15 • 02:45 | Club Jorge Wilstermann | | - | | River Plate | 3 | : | 0 |
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| Sep 21 • 02:45 | Santos FC | | - | | Barcelona SC | 0 | : | 1 |
| Sep 21 • 02:45 | Grêmio Porto Alegrense | | - | | Botafogo | 1 | : | 0 |
| Sep 22 • 00:15 | River Plate | | - | | Club Jorge Wilstermann | 8 | : | 0 |
| Sep 22 • 02:45 | CA Lanús | | - | | San Lorenzo | 2 | : | 0 |
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| Oct 24 • 22:15 | River Plate | | - | | CA Lanús | 1 | : | 0 |
| Oct 25 • 23:45 | Barcelona SC | | - | | Grêmio Porto Alegrense | 0 | : | 3 |
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| Nov 01 • 01:15 | CA Lanús | | - | | River Plate | 4 | : | 2 |
| Nov 02 • 00:45 | Grêmio Porto Alegrense | | - | | Barcelona SC | 0 | : | 1 |
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| Nov 23 • 00:45 | Grêmio Porto Alegrense | | - | | CA Lanús | 1 | : | 0 |
| Nov 30 • 00:45 | CA Lanús | | - | | Grêmio Porto Alegrense | 1 | : | 2 |
