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| Feb 05 • 01:30 | Monagas SC |  | - |  | Defensor Sporting | 2 | : | 0 |
| Feb 06 • 01:30 | Club Nacional Asunción |  | - |  | Alianza Lima | 1 | : | 1 |
| Feb 07 • 01:30 | Club Blooming |  | - |  | El Nacional | 3 | : | 2 |
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| Feb 12 • 01:30 | Defensor Sporting | | - | | Monagas SC | 0 | : | 2 |
| Feb 13 • 01:30 | Alianza Lima | | - | | Club Nacional Asunción | 3 | : | 1 |
| Feb 14 • 01:30 | El Nacional | | - | | Club Blooming | 2 | : | 1 |
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| Feb 18 • 23:00 | Deportes Iquique |  | - |  | Independiente Santa Fe | 2 | : | 1 |
| Feb 19 • 01:30 | The Strongest |  | - |  | EC Bahia | 1 | : | 1 |
| Feb 19 • 01:30 | Alianza Lima | | - |  | Boca Juniors | 1 | : | 0 |
| Feb 19 • 23:00 | Boston River |  | - |  | CD Ñublense | 1 | : | 0 |
| Feb 20 • 01:30 | El Nacional | | - |  | Barcelona SC | 0 | : | 1 |
| Feb 20 • 01:30 | Universidad Central |  | - |  | Corinthians | 1 | : | 1 |
| Feb 20 • 23:00 | Monagas SC | | - |  | Cerro Porteño | 0 | : | 4 |
| Feb 21 • 01:30 | Deportes Tolima |  | - |  | FBC Melgar | 0 | : | 1 |
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| Feb 25 • 23:00 | Independiente Santa Fe | | - | | Deportes Iquique | 2 | : | 1 |
| Feb 26 • 01:30 | EC Bahia | | - | | The Strongest | 3 | : | 0 |
| Feb 26 • 01:30 | Boca Juniors | | - | | Alianza Lima | 2 | : | 1 |
| Feb 26 • 23:00 | CD Ñublense | | - | | Boston River | 1 | : | 1 |
| Feb 27 • 01:30 | Barcelona SC | | - | | El Nacional | 1 | : | 1 |
| Feb 27 • 01:30 | Corinthians | | - | | Universidad Central | 3 | : | 2 |
| Feb 27 • 23:00 | Cerro Porteño | | - | | Monagas SC | 3 | : | 1 |
| Feb 28 • 01:30 | FBC Melgar | | - | | Deportes Tolima | 1 | : | 0 |
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| Mar 04 • 23:00 | Deportes Iquique | | - | | Alianza Lima | 1 | : | 2 |
| Mar 05 • 23:00 | FBC Melgar | | - | | Cerro Porteño | 0 | : | 1 |
| Mar 06 • 01:30 | Barcelona SC | | - | | Corinthians | 3 | : | 0 |
| Mar 07 • 01:30 | Boston River | | - | | EC Bahia | 0 | : | 0 |
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| Mar 11 • 23:00 | Alianza Lima | | - | | Deportes Iquique | 1 | : | 1 |
| Mar 12 • 23:00 | Cerro Porteño | | - | | FBC Melgar | 4 | : | 2 |
| Mar 13 • 01:30 | Corinthians | | - | | Barcelona SC | 2 | : | 0 |
| Mar 14 • 01:30 | EC Bahia | | - | | Boston River | 1 | : | 0 |
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| Group A |
Apr 02 • 00:00 | Carabobo FC |  | - |  | Estudiantes de La Plata | 0 | : | 2 |
| Group G |
Apr 02 • 00:00 | Cerro Porteño | | - |  | Club Bolívar | 4 | : | 2 |
| Group E |
Apr 02 • 02:30 | Atlético Bucaramanga |  | - |  | Colo-Colo | 3 | : | 3 |
| Group E |
Apr 02 • 02:30 | Fortaleza EC |  | - |  | Racing Club | 0 | : | 3 |
| Group B |
Apr 02 • 04:00 | Barcelona SC | | - |  | Independiente del Valle | 1 | : | 0 |
| Group D |
Apr 02 • 04:00 | Alianza Lima | | - |  | Club Libertad | 0 | : | 1 |
| Group H |
Apr 03 • 00:00 | San Antonio Bulo Bulo |  | - |  | Olimpia Asunción | 3 | : | 2 |
| Group H |
Apr 03 • 00:00 | Vélez Sársfield |  | - |  | CA Peñarol | 2 | : | 1 |
| Group A |
Apr 03 • 02:30 | Universidad de Chile |  | - |  | Botafogo | 1 | : | 0 |
| Group B |
Apr 03 • 02:30 | Universitario de Deportes |  | - |  | River Plate | 0 | : | 1 |
| Group D |
Apr 03 • 02:30 | Talleres de Córdoba |  | - |  | São Paulo FC | 0 | : | 1 |
| Group F |
Apr 03 • 04:00 | Atlético Nacional |  | - |  | Club Nacional Montevideo | 3 | : | 0 |
| Group C |
Apr 04 • 00:00 | CA Central Córdoba |  | - |  | LDU Quito | 0 | : | 0 |
| Group F |
Apr 04 • 00:00 | EC Bahia | | - |  | SC Internacional | 1 | : | 1 |
| Group G |
Apr 04 • 00:00 | Sporting Cristal |  | - |  | SE Palmeiras | 2 | : | 3 |
| Group C |
Apr 04 • 02:30 | Deportivo Táchira |  | - |  | Flamengo | 0 | : | 1 |
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| Group A |
Apr 09 • 00:00 | Botafogo | | - | | Carabobo FC | 2 | : | 0 |
| Group D |
Apr 09 • 00:00 | Club Libertad | | - | | Talleres de Córdoba | 2 | : | 0 |
| Group H |
Apr 09 • 02:00 | CA Peñarol | | - | | San Antonio Bulo Bulo | 2 | : | 0 |
| Group A |
Apr 09 • 02:30 | Estudiantes de La Plata | | - | | Universidad de Chile | 1 | : | 2 |
| Group B |
Apr 09 • 02:30 | River Plate | | - | | Barcelona SC | 0 | : | 0 |
| Group B |
Apr 09 • 04:00 | Independiente del Valle | | - | | Universitario de Deportes | 1 | : | 0 |
| Group F |
Apr 10 • 00:00 | Club Nacional Montevideo | | - | | EC Bahia | 0 | : | 1 |
| Group H |
Apr 10 • 00:00 | Olimpia Asunción | | - | | Vélez Sársfield | 0 | : | 4 |
| Group C |
Apr 10 • 02:30 | Flamengo | | - | | CA Central Córdoba | 1 | : | 2 |
| Group G |
Apr 10 • 02:30 | Club Bolívar | | - | | Sporting Cristal | 3 | : | 0 |
| Group G |
Apr 10 • 02:30 | SE Palmeiras | | - | | Cerro Porteño | 1 | : | 0 |
| Group C |
Apr 10 • 04:00 | LDU Quito | | - | | Deportivo Táchira | 2 | : | 0 |
| Group E |
Apr 11 • 00:00 | Racing Club | | - | | Atlético Bucaramanga | 1 | : | 2 |
| Group F |
Apr 11 • 00:00 | SC Internacional | | - | | Atlético Nacional | 3 | : | 0 |
| Group E |
Apr 11 • 02:00 | Colo-Colo | | - | | Fortaleza EC | 0 | : | 3 |
| Group D |
Apr 11 • 02:30 | São Paulo FC | | - | | Alianza Lima | 2 | : | 2 |
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| Group C |
Apr 23 • 00:00 | LDU Quito | | - | | Flamengo | 0 | : | 0 |
| Group D |
Apr 23 • 00:00 | Alianza Lima | | - | | Talleres de Córdoba | 3 | : | 2 |
| Group A |
Apr 23 • 01:00 | Carabobo FC | | - | | Universidad de Chile | 1 | : | 1 |
| Group E |
Apr 23 • 02:30 | Colo-Colo | | - | | Racing Club | 1 | : | 1 |
| Group F |
Apr 23 • 02:30 | SC Internacional | | - | | Club Nacional Montevideo | 3 | : | 3 |
| Group B |
Apr 23 • 04:00 | Barcelona SC | | - | | Universitario de Deportes | 0 | : | 1 |
| Group H |
Apr 24 • 00:00 | Olimpia Asunción | | - | | CA Peñarol | 0 | : | 0 |
| Group H |
Apr 24 • 00:00 | San Antonio Bulo Bulo | | - | | Vélez Sársfield | 2 | : | 1 |
| Group A |
Apr 24 • 02:30 | Estudiantes de La Plata | | - | | Botafogo | 1 | : | 0 |
| Group B |
Apr 24 • 02:30 | Independiente del Valle | | - | | River Plate | 2 | : | 2 |
| Group D |
Apr 24 • 02:30 | Club Libertad | | - | | São Paulo FC | 0 | : | 2 |
| Group E |
Apr 24 • 04:00 | Atlético Bucaramanga | | - | | Fortaleza EC | 1 | : | 1 |
| Group C |
Apr 25 • 00:00 | CA Central Córdoba | | - | | Deportivo Táchira | 2 | : | 1 |
| Group G |
Apr 25 • 00:00 | Club Bolívar | | - | | SE Palmeiras | 2 | : | 3 |
| Group F |
Apr 25 • 02:00 | EC Bahia | | - | | Atlético Nacional | 1 | : | 0 |
| Group G |
Apr 25 • 02:30 | Cerro Porteño | | - | | Sporting Cristal | 2 | : | 2 |
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| Group A |
May 07 • 00:00 | Carabobo FC | | - | | Botafogo | 1 | : | 2 |
| Group D |
May 07 • 00:00 | Alianza Lima | | - | | São Paulo FC | 0 | : | 2 |
| Group E |
May 07 • 00:00 | Atlético Bucaramanga | | - | | Racing Club | 0 | : | 4 |
| Group E |
May 07 • 02:30 | Fortaleza EC | | - | | Colo-Colo | 4 | : | 0 |
| Group H |
May 07 • 04:00 | San Antonio Bulo Bulo | | - | | CA Peñarol | 0 | : | 3 |
| Group C |
May 08 • 00:00 | Deportivo Táchira | | - | | LDU Quito | 2 | : | 3 |
| Group F |
May 08 • 00:00 | EC Bahia | | - | | Club Nacional Montevideo | 1 | : | 3 |
| Group A |
May 08 • 02:00 | Universidad de Chile | | - | | Estudiantes de La Plata | 0 | : | 3 |
| Group C |
May 08 • 02:30 | CA Central Córdoba | | - | | Flamengo | 1 | : | 1 |
| Group G |
May 08 • 02:30 | Cerro Porteño | | - | | SE Palmeiras | 0 | : | 2 |
| Group G |
May 08 • 04:00 | Sporting Cristal | | - | | Club Bolívar | 2 | : | 1 |
| Group D |
May 09 • 00:00 | Talleres de Córdoba | | - | | Club Libertad | 0 | : | 0 |
| Group H |
May 09 • 00:00 | Vélez Sársfield | | - | | Olimpia Asunción | 1 | : | 1 |
| Group B |
May 09 • 02:30 | Barcelona SC | | - | | River Plate | 2 | : | 3 |
| Group F |
May 09 • 02:30 | Atlético Nacional | | - | | SC Internacional | 3 | : | 1 |
| Group B |
May 09 • 04:00 | Universitario de Deportes | | - | | Independiente del Valle | 1 | : | 1 |
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| Group C |
May 14 • 00:00 | Deportivo Táchira | | - | | CA Central Córdoba | 1 | : | 2 |
| Group A |
May 14 • 02:30 | Universidad de Chile | | - | | Carabobo FC | 4 | : | 0 |
| Group E |
May 14 • 02:30 | Fortaleza EC | | - | | Atlético Bucaramanga | 0 | : | 0 |
| Group G |
May 14 • 02:30 | Sporting Cristal | | - | | Cerro Porteño | 0 | : | 1 |
| Group F |
May 15 • 00:00 | Atlético Nacional | | - | | EC Bahia | 1 | : | 0 |
| Group H |
May 15 • 00:00 | CA Peñarol | | - | | Olimpia Asunción | 3 | : | 2 |
| Group H |
May 15 • 00:00 | Vélez Sársfield | | - | | San Antonio Bulo Bulo | 3 | : | 0 |
| Group A |
May 15 • 02:30 | Botafogo | | - | | Estudiantes de La Plata |
| Group D |
May 15 • 02:30 | São Paulo FC | | - | | Club Libertad |
| Group E |
May 15 • 02:30 | Racing Club | | - | | Colo-Colo |
| Group B |
May 15 • 04:00 | Universitario de Deportes | | - | | Barcelona SC |
| Group D |
May 16 • 00:00 | Talleres de Córdoba | | - | | Alianza Lima |
| Group F |
May 16 • 00:00 | Club Nacional Montevideo | | - | | SC Internacional |
| Group G |
May 16 • 00:00 | SE Palmeiras | | - | | Club Bolívar |
| Group B |
May 16 • 02:30 | River Plate | | - | | Independiente del Valle |
| Group C |
May 16 • 02:30 | Flamengo | | - | | LDU Quito |
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| Group D |
May 28 • 00:00 | São Paulo FC | | - | | Talleres de Córdoba |
| Group D |
May 28 • 00:00 | Club Libertad | | - | | Alianza Lima |
| Group A |
May 28 • 02:30 | Botafogo | | - | | Universidad de Chile |
| Group A |
May 28 • 02:30 | Estudiantes de La Plata | | - | | Carabobo FC |
| Group B |
May 28 • 02:30 | River Plate | | - | | Universitario de Deportes |
| Group B |
May 28 • 02:30 | Independiente del Valle | | - | | Barcelona SC |
| Group F |
May 29 • 00:00 | Club Nacional Montevideo | | - | | Atlético Nacional |
| Group F |
May 29 • 00:00 | SC Internacional | | - | | EC Bahia |
| Group C |
May 29 • 02:30 | Flamengo | | - | | Deportivo Táchira |
| Group C |
May 29 • 02:30 | LDU Quito | | - | | CA Central Córdoba |
| Group G |
May 29 • 02:30 | SE Palmeiras | | - | | Sporting Cristal |
| Group G |
May 29 • 02:30 | Club Bolívar | | - | | Cerro Porteño |
| Group H |
May 30 • 00:00 | CA Peñarol | | - | | Vélez Sársfield |
| Group H |
May 30 • 00:00 | Olimpia Asunción | | - | | San Antonio Bulo Bulo |
| Group E |
May 30 • 02:30 | Racing Club | | - | | Fortaleza EC |
| Group E |
May 30 • 02:30 | Colo-Colo | | - | | Atlético Bucaramanga |
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