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| Guaireña FC |
 |
1 | : | 2 |
 |
Club River Plate Asunción | |
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| 2021 • Apr 09 • 00:15 |  |
Copa Sudamericana 2021 | Preliminary Round (2nd leg) | Club River Plate Asunción |
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- |
|
Guaireña FC | 4 | : | 2 | |
| 2021 • Mar 18 • 23:15 | |
Copa Sudamericana 2021 | Preliminary Round (1st leg) | Guaireña FC |
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- |
|
Club River Plate Asunción | 1 | : | 2 | |
| 2 Matches | ||||||||||||
| Kick-off time changed | |||
| time before change | time after change | Changed by | Changed when |
| 2021-03-16 00:00 | 2021-03-18 23:15 | Leslie | 2021-02-13 06:23:41 |