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| Jan 26 • 01:15 | Independiente |  | - |  | Deportivo Quito | 2 | : | 0 |
| Jan 27 • 01:00 | Corinthians |  | - |  | Deportes Tolima | 0 | : | 0 |
| Jan 27 • 01:00 | Liverpool FC |  | - |  | Grêmio Porto Alegrense | 2 | : | 2 |
| Jan 27 • 03:15 | Alianza Lima |  | - |  | Jaguares de Chiapas | 0 | : | 2 |
| Jan 28 • 00:15 | Cerro Porteño |  | - |  | Deportivo Petare | 1 | : | 0 |
| Jan 28 • 02:30 | Club Bolívar |  | - |  | Unión Española | 0 | : | 1 |
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| Feb 02 • 01:45 | Deportivo Quito | | - | | Independiente | 1 | : | 0 |
| Feb 02 • 04:15 | Jaguares de Chiapas | | - | | Alianza Lima | 2 | : | 0 |
| Feb 03 • 01:00 | Deportes Tolima | | - | | Corinthians | 2 | : | 0 |
| Feb 03 • 01:00 | Grêmio Porto Alegrense | | - | | Liverpool FC | 3 | : | 1 |
| Feb 04 • 00:00 | Unión Española | | - | | Club Bolívar | 0 | : | 0 |
| Feb 04 • 02:30 | Deportivo Petare | | - | | Cerro Porteño | 1 | : | 1 |
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| Group C |
Feb 10 • 01:00 | Fluminense FC |  | - |  | Argentinos Juniors | 2 | : | 2 |
| Group D |
Feb 15 • 23:30 | Vélez Sársfield |  | - |  | Caracas FC | 3 | : | 0 |
| Group G |
Feb 15 • 23:30 | Deportes Tolima | | - |  | Club Guaraní | 1 | : | 0 |
| Group A |
Feb 16 • 01:45 | San Luis FC |  | - |  | Club Libertad | 1 | : | 2 |
| Group E |
Feb 16 • 02:15 | Deportivo Táchira |  | - |  | Santos FC | 0 | : | 0 |
| Group C |
Feb 16 • 04:00 | Club América |  | - |  | Club Nacional Montevideo | 2 | : | 0 |
| Group D |
Feb 16 • 22:45 | Unión Española | | - |  | CD Universidad Católica | 2 | : | 2 |
| Group F |
Feb 17 • 01:00 | CS Emelec |  | - |  | SC Internacional | 1 | : | 1 |
| Group G |
Feb 17 • 01:00 | Cruzeiro EC |  | - |  | Estudiantes de La Plata | 5 | : | 0 |
| Group A |
Feb 17 • 03:15 | Once Caldas |  | - |  | Universidad San Martín | 0 | : | 3 |
| Group F |
Feb 17 • 03:15 | Jaguares de Chiapas | | - |  | Club Jorge Wilstermann | 2 | : | 0 |
| Group B |
Feb 17 • 20:30 | León de Huánuco |  | - |  | Atlético Junior | 1 | : | 2 |
| Group B |
Feb 17 • 22:45 | Grêmio Porto Alegrense | | - |  | Oriente Petrolero | 3 | : | 0 |
| Group E |
Feb 18 • 00:00 | Cerro Porteño | | - |  | Colo-Colo | 5 | : | 2 |
| Group H |
Feb 18 • 02:15 | Godoy Cruz |  | - |  | LDU Quito | 2 | : | 1 |
| Group H |
Feb 24 • 23:15 | Independiente | | - |  | CA Peñarol | 3 | : | 0 |
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| Group G |
Feb 22 • 23:15 | Cruzeiro EC | | - | | Club Guaraní | 4 | : | 0 |
| Group A |
Feb 23 • 01:30 | Universidad San Martín | | - | | San Luis FC | 2 | : | 0 |
| Group F |
Feb 23 • 01:30 | CS Emelec | | - | | Club Jorge Wilstermann | 1 | : | 0 |
| Group A |
Feb 23 • 03:45 | Once Caldas | | - | | Club Libertad | 1 | : | 1 |
| Group B |
Feb 23 • 21:15 | León de Huánuco | | - | | Oriente Petrolero | 1 | : | 0 |
| Group G |
Feb 23 • 23:30 | Estudiantes de La Plata | | - | | Deportes Tolima | 1 | : | 0 |
| Group C |
Feb 24 • 01:50 | Fluminense FC | | - | | Club Nacional Montevideo | 0 | : | 0 |
| Group F |
Feb 24 • 01:50 | SC Internacional | | - | | Jaguares de Chiapas | 4 | : | 0 |
| Group C |
Feb 25 • 01:30 | Argentinos Juniors | | - | | Club América | 3 | : | 1 |
| Group B |
Feb 25 • 03:45 | Atlético Junior | | - | | Grêmio Porto Alegrense | 2 | : | 1 |
| Group H |
Mar 02 • 00:15 | Godoy Cruz | | - | | CA Peñarol | 1 | : | 3 |
| Group E |
Mar 02 • 02:30 | Deportivo Táchira | | - | | Colo-Colo | 2 | : | 4 |
| Group E |
Mar 03 • 01:50 | Santos FC | | - | | Cerro Porteño | 1 | : | 1 |
| Group D |
Mar 04 • 00:15 | Vélez Sársfield | | - | | CD Universidad Católica | 3 | : | 4 |
| Group D |
Mar 04 • 02:30 | Caracas FC | | - | | Unión Española | 2 | : | 0 |
| Group H |
Mar 04 • 02:30 | LDU Quito | | - | | Independiente | 3 | : | 0 |
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| Group C |
Mar 02 • 23:30 | Club Nacional Montevideo | | - | | Argentinos Juniors | 0 | : | 1 |
| Group G |
Mar 02 • 23:30 | Deportes Tolima | | - | | Cruzeiro EC | 0 | : | 0 |
| Group C |
Mar 03 • 01:50 | Club América | | - | | Fluminense FC | 1 | : | 0 |
| Group A |
Mar 03 • 04:15 | San Luis FC | | - | | Once Caldas | 1 | : | 1 |
| Group B |
Mar 04 • 00:15 | Grêmio Porto Alegrense | | - | | León de Huánuco | 2 | : | 0 |
| Group A |
Mar 08 • 23:15 | Club Libertad | | - | | Universidad San Martín | 5 | : | 1 |
| Group F |
Mar 09 • 03:45 | Jaguares de Chiapas | | - | | CS Emelec | 2 | : | 1 |
| Group B |
Mar 09 • 23:30 | Oriente Petrolero | | - | | Atlético Junior | 1 | : | 2 |
| Group H |
Mar 09 • 23:30 | CA Peñarol | | - | | LDU Quito | 1 | : | 0 |
| Group D |
Mar 10 • 01:45 | CD Universidad Católica | | - | | Caracas FC | 1 | : | 3 |
| Group G |
Mar 10 • 01:45 | Club Guaraní | | - | | Estudiantes de La Plata | 1 | : | 2 |
| Group D |
Mar 10 • 23:15 | Unión Española | | - | | Vélez Sársfield | 2 | : | 1 |
| Group E |
Mar 10 • 23:15 | Cerro Porteño | | - | | Deportivo Táchira | 1 | : | 1 |
| Group H |
Mar 11 • 01:45 | Independiente | | - | | Godoy Cruz | 1 | : | 3 |
| Group F |
Mar 16 • 23:30 | Club Jorge Wilstermann | | - | | SC Internacional | 1 | : | 4 |
| Group E |
Mar 17 • 01:50 | Colo-Colo | | - | | Santos FC | 3 | : | 2 |
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| Group A |
Mar 15 • 23:45 | Universidad San Martín | | - | | Club Libertad | 0 | : | 1 |
| Group C |
Mar 16 • 01:30 | Argentinos Juniors | | - | | Club Nacional Montevideo | 0 | : | 1 |
| Group A |
Mar 16 • 03:45 | Once Caldas | | - | | San Luis FC | 1 | : | 1 |
| Group F |
Mar 17 • 01:50 | CS Emelec | | - | | Jaguares de Chiapas | 1 | : | 0 |
| Group G |
Mar 17 • 01:50 | Cruzeiro EC | | - | | Deportes Tolima | 6 | : | 1 |
| Group B |
Mar 17 • 21:00 | León de Huánuco | | - | | Grêmio Porto Alegrense | 1 | : | 1 |
| Group G |
Mar 17 • 23:15 | Estudiantes de La Plata | | - | | Club Guaraní | 5 | : | 1 |
| Group H |
Mar 18 • 01:30 | LDU Quito | | - | | CA Peñarol | 5 | : | 0 |
| Group B |
Mar 18 • 03:45 | Atlético Junior | | - | | Oriente Petrolero | 2 | : | 1 |
| Group D |
Mar 23 • 01:15 | Caracas FC | | - | | CD Universidad Católica | 0 | : | 2 |
| Group H |
Mar 23 • 23:30 | Godoy Cruz | | - | | Independiente | 1 | : | 1 |
| Group C |
Mar 24 • 01:50 | Fluminense FC | | - | | Club América | 3 | : | 2 |
| Group D |
Mar 25 • 01:45 | Vélez Sársfield | | - | | Unión Española | 2 | : | 1 |
| Group F |
Mar 31 • 02:50 | SC Internacional | | - | | Club Jorge Wilstermann | 3 | : | 0 |
| Group E |
Apr 07 • 00:30 | Deportivo Táchira | | - | | Cerro Porteño | 0 | : | 2 |
| Group E |
Apr 07 • 02:50 | Santos FC | | - | | Colo-Colo | 3 | : | 2 |
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| Group A |
Mar 23 • 01:15 | Club Libertad | | - | | Once Caldas | 2 | : | 2 |
| Group A |
Mar 23 • 03:30 | San Luis FC | | - | | Universidad San Martín | 3 | : | 1 |
| Group B |
Mar 24 • 23:30 | Oriente Petrolero | | - | | León de Huánuco | 2 | : | 0 |
| Group G |
Mar 31 • 00:30 | Deportes Tolima | | - | | Estudiantes de La Plata | 1 | : | 1 |
| Group G |
Mar 31 • 02:50 | Club Guaraní | | - | | Cruzeiro EC | 0 | : | 2 |
| Group H |
Apr 01 • 02:15 | CA Peñarol | | - | | Godoy Cruz | 2 | : | 1 |
| Group H |
Apr 06 • 02:15 | Independiente | | - | | LDU Quito | 1 | : | 1 |
| Group D |
Apr 07 • 00:30 | Unión Española | | - | | Caracas FC | 1 | : | 2 |
| Group F |
Apr 07 • 00:30 | Jaguares de Chiapas | | - | | SC Internacional | 1 | : | 0 |
| Group C |
Apr 07 • 02:45 | Club Nacional Montevideo | | - | | Fluminense FC | 2 | : | 0 |
| Group C |
Apr 07 • 04:50 | Club América | | - | | Argentinos Juniors | 2 | : | 1 |
| Group B |
Apr 08 • 00:15 | Grêmio Porto Alegrense | | - | | Atlético Junior | 2 | : | 0 |
| Group F |
Apr 08 • 00:15 | Club Jorge Wilstermann | | - | | CS Emelec | 0 | : | 0 |
| Group D |
Apr 08 • 02:30 | CD Universidad Católica | | - | | Vélez Sársfield | 0 | : | 0 |
| Group E |
Apr 13 • 02:30 | Colo-Colo | | - | | Deportivo Táchira | 2 | : | 1 |
| Group E |
Apr 15 • 01:30 | Cerro Porteño | | - | | Santos FC | 1 | : | 2 |
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| Group H |
Apr 13 • 00:15 | CA Peñarol | | - | | Independiente | 0 | : | 1 |
| Group H |
Apr 13 • 00:15 | LDU Quito | | - | | Godoy Cruz | 2 | : | 0 |
| Group G |
Apr 14 • 02:50 | Club Guaraní | | - | | Deportes Tolima | 0 | : | 2 |
| Group G |
Apr 14 • 02:50 | Estudiantes de La Plata | | - | | Cruzeiro EC | 0 | : | 3 |
| Group D |
Apr 15 • 01:30 | CD Universidad Católica | | - | | Unión Española | 2 | : | 1 |
| Group D |
Apr 15 • 01:30 | Caracas FC | | - | | Vélez Sársfield | 0 | : | 3 |
| Group B |
Apr 15 • 03:45 | Oriente Petrolero | | - | | Grêmio Porto Alegrense | 3 | : | 0 |
| Group B |
Apr 15 • 03:45 | Atlético Junior | | - | | León de Huánuco | 1 | : | 1 |
| Group F |
Apr 20 • 01:15 | Club Jorge Wilstermann | | - | | Jaguares de Chiapas | 2 | : | 1 |
| Group F |
Apr 20 • 01:15 | SC Internacional | | - | | CS Emelec | 2 | : | 0 |
| Group A |
Apr 20 • 03:30 | Club Libertad | | - | | San Luis FC | 2 | : | 0 |
| Group A |
Apr 20 • 03:30 | Universidad San Martín | | - | | Once Caldas | 0 | : | 2 |
| Group E |
Apr 21 • 00:30 | Colo-Colo | | - | | Cerro Porteño | 2 | : | 3 |
| Group E |
Apr 21 • 00:30 | Santos FC | | - | | Deportivo Táchira | 3 | : | 1 |
| Group C |
Apr 21 • 02:50 | Club Nacional Montevideo | | - | | Club América | 0 | : | 0 |
| Group C |
Apr 21 • 02:50 | Argentinos Juniors | | - | | Fluminense FC | 2 | : | 4 |
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| Apr 27 • 00:30 | Grêmio Porto Alegrense | | - | | CD Universidad Católica | 1 | : | 2 |
| Apr 27 • 02:50 | Vélez Sársfield | | - | | LDU Quito | 3 | : | 0 |
| Apr 28 • 00:30 | Jaguares de Chiapas | | - | | Atlético Junior | 1 | : | 1 |
| Apr 28 • 00:30 | Estudiantes de La Plata | | - | | Cerro Porteño | 0 | : | 0 |
| Apr 28 • 02:50 | Once Caldas | | - | | Cruzeiro EC | 1 | : | 2 |
| Apr 28 • 02:50 | Santos FC | | - | | Club América | 1 | : | 0 |
| Apr 29 • 00:30 | CA Peñarol | | - | | SC Internacional | 1 | : | 1 |
| Apr 29 • 02:50 | Fluminense FC | | - | | Club Libertad | 3 | : | 1 |
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| May 04 • 03:45 | Club América | | - | | Santos FC | 0 | : | 0 |
| May 05 • 00:30 | SC Internacional | | - | | CA Peñarol | 1 | : | 2 |
| May 05 • 02:50 | Club Libertad | | - | | Fluminense FC | 3 | : | 0 |
| May 05 • 02:50 | Cruzeiro EC | | - | | Once Caldas | 0 | : | 2 |
| May 05 • 02:50 | CD Universidad Católica | | - | | Grêmio Porto Alegrense | 1 | : | 0 |
| May 06 • 01:15 | Cerro Porteño | | - | | Estudiantes de La Plata | 5 | : | 3 |
| May 06 • 03:45 | LDU Quito | | - | | Vélez Sársfield | 0 | : | 2 |
| May 06 • 03:45 | Atlético Junior | | - | | Jaguares de Chiapas | 3 | : | 3 |
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| May 12 • 00:30 | CA Peñarol | | - | | CD Universidad Católica | 2 | : | 0 |
| May 12 • 02:50 | Once Caldas | | - | | Santos FC | 0 | : | 1 |
| May 13 • 01:15 | Vélez Sársfield | | - | | Club Libertad | 3 | : | 0 |
| May 13 • 03:45 | Jaguares de Chiapas | | - | | Cerro Porteño | 1 | : | 1 |
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| May 19 • 00:30 | Club Libertad | | - | | Vélez Sársfield | 2 | : | 4 |
| May 19 • 03:00 | Santos FC | | - | | Once Caldas | 1 | : | 1 |
| May 20 • 01:00 | CD Universidad Católica | | - | | CA Peñarol | 2 | : | 1 |
| May 20 • 03:30 | Cerro Porteño | | - | | Jaguares de Chiapas | 1 | : | 0 |
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| May 26 • 02:50 | Santos FC | | - | | Cerro Porteño | 1 | : | 0 |
| May 27 • 02:50 | CA Peñarol | | - | | Vélez Sársfield | 1 | : | 0 |
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| Jun 02 • 02:50 | Cerro Porteño | | - | | Santos FC | 3 | : | 3 |
| Jun 03 • 02:50 | Vélez Sársfield | | - | | CA Peñarol | 2 | : | 1 |
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| Jun 16 • 02:50 | CA Peñarol | | - | | Santos FC | 0 | : | 0 |
| Jun 23 • 02:50 | Santos FC | | - | | CA Peñarol | 2 | : | 1 |
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