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| Feb 29 • 19:00 | Washington DC United |  | - |  | Colorado Rapids | 1 | : | 2 |
| Feb 29 • 21:00 | Montreal Impact |  | - |  | New England Revolution | 2 | : | 1 |
| Feb 29 • 21:30 | Houston Dynamo |  | - |  | Los Angeles Galaxy | 1 | : | 1 |
| Feb 29 • 23:30 | San Jose Earthquakes |  | - |  | Toronto FC | 2 | : | 2 |
| Mar 01 • 00:00 | FC Dallas |  | - |  | Philadelphia Union | 2 | : | 0 |
| Mar 01 • 00:00 | Orlando City SC |  | - |  | Real Salt Lake | 0 | : | 0 |
| Mar 01 • 02:00 | Nashville SC |  | - |  | Atlanta United | 1 | : | 2 |
| Mar 01 • 04:30 | Vancouver Whitecaps |  | - |  | Sporting Kansas City | 1 | : | 3 |
| Mar 01 • 18:30 | Columbus Crew |  | - |  | New York City FC | 1 | : | 0 |
| Mar 01 • 19:00 | New York Red Bulls |  | - |  | FC Cincinnati | 3 | : | 2 |
| Mar 01 • 21:00 | Seattle Sounders |  | - |  | Chicago Fire | 2 | : | 1 |
| Mar 01 • 23:30 | Los Angeles FC |  | - |  | Inter Miami | 1 | : | 0 |
| Mar 02 • 01:30 | Portland Timbers |  | - |  | Minnesota United | 1 | : | 3 |
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| Mar 07 • 19:30 | New England Revolution | | - | | Chicago Fire | 1 | : | 1 |
| Mar 07 • 20:00 | Real Salt Lake | | - | | New York Red Bulls | 1 | : | 1 |
| Mar 07 • 21:00 | FC Dallas | | - | | Montreal Impact | 2 | : | 2 |
| Mar 07 • 21:30 | Washington DC United | | - | | Inter Miami | 2 | : | 1 |
| Mar 07 • 23:00 | Toronto FC | | - | | New York City FC | 1 | : | 0 |
| Mar 08 • 01:00 | Atlanta United | | - | | FC Cincinnati | 2 | : | 1 |
| Mar 08 • 02:00 | San Jose Earthquakes | | - | | Minnesota United | 2 | : | 5 |
| Mar 08 • 02:30 | Sporting Kansas City | | - | | Houston Dynamo | 4 | : | 0 |
| Mar 08 • 03:00 | Colorado Rapids | | - | | Orlando City SC | 2 | : | 1 |
| Mar 08 • 04:00 | Los Angeles Galaxy | | - | | Vancouver Whitecaps | 0 | : | 1 |
| Mar 08 • 04:00 | Seattle Sounders | | - | | Columbus Crew | 1 | : | 1 |
| Mar 09 • 00:00 | Portland Timbers | | - | | Nashville SC | 1 | : | 0 |
| Mar 09 • 03:30 | Los Angeles FC | | - | | Philadelphia Union | 3 | : | 3 |
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| Jul 09 • 02:00 | Orlando City SC | | - | | Inter Miami | 2 | : | 1 |
| Jul 09 • 15:00 | New York City FC | | - | | Philadelphia Union | 0 | : | 1 |
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| Jul 10 • 02:00 | Montreal Impact | | - | | New England Revolution | 0 | : | 1 |
| Jul 11 • 03:00 | Seattle Sounders | | - | | San Jose Earthquakes | 0 | : | 0 |
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| Jul 12 • 02:00 | Atlanta United | | - | | New York Red Bulls | 0 | : | 1 |
| Jul 12 • 04:30 | FC Cincinnati | | - | | Columbus Crew | 0 | : | 4 |
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| Jul 13 • 02:00 | Sporting Kansas City | | - | | Minnesota United | 1 | : | 2 |
| Jul 13 • 04:30 | Real Salt Lake | | - | | Colorado Rapids | 2 | : | 0 |
| Jul 13 • 15:00 | Toronto FC | | - | | Washington DC United | 2 | : | 2 |
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| Jul 14 • 02:00 | Los Angeles FC | | - | | Houston Dynamo | 3 | : | 3 |
| Jul 14 • 04:30 | Los Angeles Galaxy | | - | | Portland Timbers | 1 | : | 2 |
| Jul 14 • 15:00 | Chicago Fire | | - | | Seattle Sounders | 2 | : | 1 |
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| Jul 15 • 02:00 | New York City FC | | - | | Orlando City SC | 1 | : | 3 |
| Jul 15 • 04:30 | Philadelphia Union | | - | | Inter Miami | 2 | : | 1 |
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| Jul 16 • 03:00 | Vancouver Whitecaps | | - | | San Jose Earthquakes | 3 | : | 4 |
| Jul 16 • 15:00 | Atlanta United | | - | | FC Cincinnati | 0 | : | 1 |
| Jul 17 • 02:00 | Montreal Impact | | - | | Toronto FC | 3 | : | 4 |
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| Jul 17 • 04:30 | Columbus Crew | | - | | New York Red Bulls | 2 | : | 0 |
| Jul 18 • 02:00 | Washington DC United | | - | | New England Revolution | 1 | : | 1 |
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| Jul 18 • 02:00 | Sporting Kansas City | | - | | Colorado Rapids | 3 | : | 2 |
| Jul 18 • 04:30 | Real Salt Lake | | - | | Minnesota United | 0 | : | 0 |
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| Jul 19 • 02:00 | Portland Timbers | | - | | Houston Dynamo | 2 | : | 1 |
| Jul 19 • 04:30 | Los Angeles FC | | - | | Los Angeles Galaxy | 6 | : | 2 |
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| Jul 20 • 02:00 | Chicago Fire | | - | | San Jose Earthquakes | 0 | : | 2 |
| Jul 20 • 04:30 | Seattle Sounders | | - | | Vancouver Whitecaps | 3 | : | 0 |
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| Jul 20 • 15:00 | Inter Miami | | - | | New York City FC | 0 | : | 1 |
| Jul 21 • 02:00 | Philadelphia Union | | - | | Orlando City SC | 1 | : | 1 |
| Jul 21 • 15:00 | Toronto FC | | - | | New England Revolution | 0 | : | 0 |
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| Jul 22 • 02:00 | Atlanta United | | - | | Columbus Crew | 0 | : | 1 |
| Jul 22 • 04:30 | Montreal Impact | | - | | Washington DC United | 1 | : | 0 |
| Jul 22 • 15:00 | Real Salt Lake | | - | | Sporting Kansas City | 0 | : | 2 |
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| Jul 23 • 02:00 | FC Cincinnati | | - | | New York Red Bulls | 2 | : | 0 |
| Jul 23 • 04:30 | Colorado Rapids | | - | | Minnesota United | 2 | : | 2 |
| Jul 23 • 15:00 | Chicago Fire | | - | | Vancouver Whitecaps | 0 | : | 2 |
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| Jul 24 • 02:00 | Los Angeles Galaxy | | - | | Houston Dynamo | 1 | : | 1 |
| Jul 24 • 04:30 | Los Angeles FC | | - | | Portland Timbers | 2 | : | 2 |
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| Jul 26 • 02:00 | Orlando City SC | | - | | Montreal Impact | 1 | : | 0 |
| Jul 26 • 04:30 | Philadelphia Union | | - | | New England Revolution | 1 | : | 0 |
| Jul 27 • 02:30 | Toronto FC | | - | | New York City FC | 1 | : | 3 |
| Jul 27 • 05:00 | Sporting Kansas City | | - | | Vancouver Whitecaps | 0 | : | 0 |
| Jul 28 • 02:30 | San Jose Earthquakes | | - | | Real Salt Lake | 5 | : | 2 |
| Jul 28 • 05:00 | Seattle Sounders | | - | | Los Angeles FC | 1 | : | 4 |
| Jul 29 • 02:00 | Columbus Crew | | - | | Minnesota United | 1 | : | 1 |
| Jul 29 • 04:30 | Portland Timbers | | - | | FC Cincinnati | 1 | : | 1 |
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| Jul 31 • 02:00 | Philadelphia Union | | - | | Sporting Kansas City | 3 | : | 1 |
| Aug 01 • 01:30 | Orlando City SC | | - | | Los Angeles FC | 1 | : | 1 |
| Aug 02 • 02:00 | San Jose Earthquakes | | - | | Minnesota United | 1 | : | 4 |
| Aug 02 • 04:30 | New York City FC | | - | | Portland Timbers | 1 | : | 3 |
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| Aug 06 • 02:00 | Philadelphia Union | | - | | Portland Timbers | 1 | : | 2 |
| Aug 07 • 02:00 | Orlando City SC | | - | | Minnesota United | 3 | : | 1 |
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| Aug 12 • 02:30 | Portland Timbers | | - | | Orlando City SC | 2 | : | 1 |
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