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| Mar 16 • 23:15 | CSD Macará |  | - |  | CS Emelec | 2 | : | 2 |
| Mar 16 • 23:15 | Club 12 de Octubre |  | - |  | Club Nacional Asunción | 0 | : | 0 |
| Mar 17 • 01:30 | Deportes Antofagasta |  | - |  | CD Huachipato | 0 | : | 1 |
| Mar 17 • 01:30 | Deportes Tolima |  | - |  | Deportivo Cali | 3 | : | 0 |
| Mar 17 • 23:15 | Club Guabirá |  | - |  | Nacional Potosí | 4 | : | 1 |
| Mar 18 • 01:30 | Club Jorge Wilstermann |  | - |  | Atlético Palmaflor | 2 | : | 1 |
| Mar 18 • 01:30 | Universidad Técnica de Cajamarca |  | - |  | Sport Huancayo | 0 | : | 1 |
| Mar 18 • 01:30 | Aragua FC |  | - |  | Mineros de Guayana | 0 | : | 1 |
| Mar 18 • 23:15 | SD Aucas |  | - |  | Guayaquil City | 2 | : | 1 |
| Mar 18 • 23:15 | Guaireña FC |  | - |  | Club River Plate Asunción | 1 | : | 2 |
| Mar 18 • 23:15 | Metropolitanos FC |  | - |  | Academia Puerto Cabello | 2 | : | 0 |
| Mar 19 • 01:30 | La Equidad |  | - |  | Deportivo Pasto | 1 | : | 2 |
| Mar 19 • 01:30 | Carlos A. Mannucci |  | - |  | FBC Melgar | 1 | : | 2 |
| Mar 19 • 01:30 | CD Cobresal |  | - |  | CD Palestino | 0 | : | 0 |
| Apr 07 • 02:30 | Cerro Largo FC |  | - |  | CA Peñarol | 2 | : | 2 |
| Apr 08 • 00:15 | Montevideo City Torque |  | - |  | CA Fénix | 0 | : | 0 |
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| Apr 07 • 00:15 | CS Emelec | | - | | CSD Macará | 2 | : | 0 |
| Apr 07 • 00:15 | Club Nacional Asunción | | - | | Club 12 de Octubre | 0 | : | 0 |
| Apr 07 • 02:30 | CD Huachipato | | - | | Deportes Antofagasta | 3 | : | 0 |
| Apr 07 • 02:30 | Deportivo Cali | | - | | Deportes Tolima | 0 | : | 0 |
| Apr 08 • 00:15 | Nacional Potosí | | - | | Club Guabirá | 1 | : | 2 |
| Apr 08 • 00:15 | Mineros de Guayana | | - | | Aragua FC | 1 | : | 2 |
| Apr 08 • 02:30 | Atlético Palmaflor | | - | | Club Jorge Wilstermann | 1 | : | 2 |
| Apr 08 • 02:30 | Sport Huancayo | | - | | Universidad Técnica de Cajamarca | 4 | : | 0 |
| Apr 09 • 00:15 | Guayaquil City | | - | | SD Aucas | 0 | : | 3 |
| Apr 09 • 00:15 | Club River Plate Asunción | | - | | Guaireña FC | 4 | : | 2 |
| Apr 09 • 00:15 | Academia Puerto Cabello | | - | | Metropolitanos FC | 0 | : | 1 |
| Apr 09 • 02:30 | CD Palestino | | - | | CD Cobresal | 2 | : | 1 |
| Apr 09 • 02:30 | Deportivo Pasto | | - | | La Equidad | 0 | : | 2 |
| Apr 09 • 02:30 | FBC Melgar | | - | | Carlos A. Mannucci | 3 | : | 2 |
| Apr 14 • 02:30 | CA Peñarol | | - | | Cerro Largo FC | 4 | : | 1 |
| Apr 15 • 00:15 | CA Fénix | | - | | Montevideo City Torque | 0 | : | 2 |
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| Group D |
Apr 21 • 00:15 | Metropolitanos FC | | - | | FBC Melgar | 2 | : | 3 |
| Group F |
Apr 21 • 00:15 | Atlético Clube Goianiense |  | - |  | Newell's Old Boys | 0 | : | 0 |
| Group A |
Apr 21 • 02:30 | Club 12 de Octubre | | - |  | Rosario Central | 1 | : | 0 |
| Group D |
Apr 21 • 02:30 | SD Aucas | | - |  | Club Athletico Paranaense | 0 | : | 1 |
| Group A |
Apr 22 • 00:15 | San Lorenzo |  | - | | CD Huachipato | 0 | : | 1 |
| Group C |
Apr 22 • 00:15 | Ceará SC |  | - | | Club Jorge Wilstermann | 3 | : | 1 |
| Group B |
Apr 22 • 02:30 | Montevideo City Torque | | - |  | EC Bahia | 1 | : | 1 |
| Group B |
Apr 22 • 02:30 | Club Guabirá | | - |  | Independiente | 1 | : | 3 |
| Group G |
Apr 22 • 21:00 | Talleres de Córdoba |  | - | | CS Emelec | 1 | : | 2 |
| Group C |
Apr 23 • 00:15 | Club Bolívar |  | - |  | Arsenal de Sarandí | 2 | : | 1 |
| Group G |
Apr 23 • 00:15 | RB Bragantino |  | - | | Deportes Tolima | 2 | : | 1 |
| Group H |
Apr 23 • 00:15 | Grêmio Porto Alegrense |  | - | | La Equidad | 2 | : | 1 |
| Group H |
Apr 23 • 00:15 | Aragua FC | | - |  | CA Lanús | 0 | : | 1 |
| Group E |
Apr 23 • 02:30 | CA Peñarol | | - | | Sport Huancayo | 5 | : | 1 |
| Group E |
Apr 23 • 02:30 | Club River Plate Asunción | | - |  | Corinthians | 0 | : | 0 |
| Group F |
Apr 23 • 02:30 | Club Libertad |  | - | | CD Palestino | 2 | : | 0 |
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| Group B |
Apr 28 • 00:15 | EC Bahia | | - | | Club Guabirá | 5 | : | 0 |
| Group A |
Apr 28 • 02:30 | CD Huachipato | | - | | Club 12 de Octubre | 0 | : | 0 |
| Group C |
Apr 28 • 02:30 | Arsenal de Sarandí | | - | | Ceará SC | 0 | : | 0 |
| Group B |
Apr 29 • 00:15 | Independiente | | - | | Montevideo City Torque | 3 | : | 1 |
| Group D |
Apr 29 • 00:15 | Club Athletico Paranaense | | - | | Metropolitanos FC | 1 | : | 0 |
| Group A |
Apr 29 • 02:30 | Rosario Central | | - | | San Lorenzo | 2 | : | 0 |
| Group D |
Apr 29 • 02:30 | FBC Melgar | | - | | SD Aucas | 2 | : | 0 |
| Group G |
Apr 29 • 02:30 | Deportes Tolima | | - | | Talleres de Córdoba | 1 | : | 1 |
| Group G |
Apr 29 • 02:30 | CS Emelec | | - | | RB Bragantino | 3 | : | 0 |
| Group C |
Apr 30 • 00:15 | Club Jorge Wilstermann | | - | | Club Bolívar | 0 | : | 0 |
| Group E |
Apr 30 • 00:15 | Sport Huancayo | | - | | Club River Plate Asunción | 1 | : | 2 |
| Group E |
Apr 30 • 00:15 | Corinthians | | - | | CA Peñarol | 0 | : | 2 |
| Group F |
Apr 30 • 02:30 | CD Palestino | | - | | Atlético Clube Goianiense | 0 | : | 1 |
| Group F |
Apr 30 • 02:30 | Newell's Old Boys | | - | | Club Libertad | 1 | : | 3 |
| Group H |
Apr 30 • 02:30 | La Equidad | | - | | Aragua FC | 2 | : | 1 |
| Group H |
Apr 30 • 02:30 | CA Lanús | | - | | Grêmio Porto Alegrense | 1 | : | 2 |
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| Group B |
May 05 • 00:15 | EC Bahia | | - | | Independiente | 2 | : | 2 |
| Group D |
May 05 • 00:15 | Metropolitanos FC | | - | | SD Aucas | 3 | : | 2 |
| Group D |
May 05 • 02:30 | FBC Melgar | | - | | Club Athletico Paranaense | 1 | : | 0 |
| Group F |
May 05 • 04:00 | CD Palestino | | - | | Newell's Old Boys | 0 | : | 1 |
| Group A |
May 06 • 00:15 | CD Huachipato | | - | | Rosario Central | 1 | : | 1 |
| Group B |
May 06 • 00:15 | Montevideo City Torque | | - | | Club Guabirá | 4 | : | 0 |
| Group C |
May 06 • 00:15 | Club Bolívar | | - | | Ceará SC | 0 | : | 0 |
| Group G |
May 06 • 02:30 | RB Bragantino | | - | | Talleres de Córdoba | 0 | : | 1 |
| Group C |
May 07 • 00:15 | Arsenal de Sarandí | | - | | Club Jorge Wilstermann | 3 | : | 0 |
| Group F |
May 07 • 00:15 | Club Libertad | | - | | Atlético Clube Goianiense | 1 | : | 2 |
| Group H |
May 07 • 00:15 | Grêmio Porto Alegrense | | - | | Aragua FC | 8 | : | 0 |
| Group A |
May 07 • 02:30 | San Lorenzo | | - | | Club 12 de Octubre | 1 | : | 1 |
| Group E |
May 07 • 02:30 | Sport Huancayo | | - | | Corinthians | 0 | : | 3 |
| Group E |
May 07 • 02:30 | CA Peñarol | | - | | Club River Plate Asunción | 3 | : | 0 |
| Group H |
May 07 • 04:00 | La Equidad | | - | | CA Lanús | 0 | : | 1 |
| Group G |
May 08 • 02:00 | Deportes Tolima | | - | | CS Emelec | 0 | : | 0 |
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| Group D |
May 12 • 00:15 | Metropolitanos FC | | - | | Club Athletico Paranaense | 0 | : | 1 |
| Group G |
May 12 • 00:15 | RB Bragantino | | - | | CS Emelec | 2 | : | 0 |
| Group B |
May 12 • 02:30 | Montevideo City Torque | | - | | Independiente | 1 | : | 1 |
| Group G |
May 12 • 02:30 | Talleres de Córdoba | | - | | Deportes Tolima | 0 | : | 0 |
| Group A |
May 13 • 00:15 | Club 12 de Octubre | | - | | CD Huachipato | 1 | : | 2 |
| Group C |
May 13 • 00:15 | Ceará SC | | - | | Arsenal de Sarandí | 0 | : | 0 |
| Group A |
May 13 • 02:30 | San Lorenzo | | - | | Rosario Central | 1 | : | 2 |
| Group C |
May 13 • 02:30 | Club Bolívar | | - | | Club Jorge Wilstermann | 2 | : | 2 |
| Group F |
May 13 • 02:30 | Atlético Clube Goianiense | | - | | CD Palestino | 0 | : | 0 |
| Group B |
May 14 • 00:15 | Club Guabirá | | - | | EC Bahia | 0 | : | 1 |
| Group H |
May 14 • 00:15 | Aragua FC | | - | | La Equidad | 1 | : | 2 |
| Group H |
May 14 • 00:15 | Grêmio Porto Alegrense | | - | | CA Lanús | 3 | : | 1 |
| Group D |
May 14 • 02:30 | SD Aucas | | - | | FBC Melgar | 2 | : | 1 |
| Group E |
May 14 • 02:30 | Club River Plate Asunción | | - | | Sport Huancayo | 2 | : | 1 |
| Group E |
May 14 • 02:30 | CA Peñarol | | - | | Corinthians | 4 | : | 0 |
| Group F |
May 14 • 02:30 | Club Libertad | | - | | Newell's Old Boys | 1 | : | 0 |
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| Group B |
May 19 • 00:15 | Independiente | | - | | EC Bahia | 1 | : | 0 |
| Group E |
May 19 • 00:15 | Club River Plate Asunción | | - | | CA Peñarol | 2 | : | 1 |
| Group G |
May 19 • 02:30 | Talleres de Córdoba | | - | | RB Bragantino | 0 | : | 1 |
| Group C |
May 20 • 00:15 | Club Jorge Wilstermann | | - | | Arsenal de Sarandí | 1 | : | 2 |
| Group F |
May 20 • 00:15 | Atlético Clube Goianiense | | - | | Club Libertad | 0 | : | 0 |
| Group G |
May 20 • 00:15 | CS Emelec | | - | | Deportes Tolima | 2 | : | 0 |
| Group A |
May 20 • 02:30 | Rosario Central | | - | | CD Huachipato | 5 | : | 0 |
| Group D |
May 20 • 02:30 | Club Athletico Paranaense | | - | | FBC Melgar | 1 | : | 0 |
| Group D |
May 20 • 02:30 | SD Aucas | | - | | Metropolitanos FC | 3 | : | 0 |
| Group A |
May 21 • 00:15 | Club 12 de Octubre | | - | | San Lorenzo | 0 | : | 2 |
| Group C |
May 21 • 00:15 | Ceará SC | | - | | Club Bolívar | 2 | : | 0 |
| Group F |
May 21 • 00:15 | Newell's Old Boys | | - | | CD Palestino | 3 | : | 1 |
| Group B |
May 21 • 02:30 | Club Guabirá | | - | | Montevideo City Torque | 0 | : | 4 |
| Group E |
May 21 • 02:30 | Corinthians | | - | | Sport Huancayo | 5 | : | 0 |
| Group H |
May 21 • 02:30 | CA Lanús | | - | | La Equidad | 4 | : | 1 |
| Group H |
May 21 • 02:30 | Aragua FC | | - | | Grêmio Porto Alegrense | 2 | : | 6 |
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| Group F |
May 26 • 00:15 | Newell's Old Boys | | - | | Atlético Clube Goianiense | 1 | : | 1 |
| Group F |
May 26 • 00:15 | CD Palestino | | - | | Club Libertad | 1 | : | 2 |
| Group G |
May 26 • 02:30 | CS Emelec | | - | | Talleres de Córdoba | 1 | : | 4 |
| Group G |
May 26 • 02:30 | Deportes Tolima | | - | | RB Bragantino | 1 | : | 2 |
| Group B |
May 27 • 00:15 | Independiente | | - | | Club Guabirá | 1 | : | 0 |
| Group B |
May 27 • 00:15 | EC Bahia | | - | | Montevideo City Torque | 2 | : | 4 |
| Group A |
May 27 • 02:30 | Rosario Central | | - | | Club 12 de Octubre | 0 | : | 0 |
| Group A |
May 27 • 02:30 | CD Huachipato | | - | | San Lorenzo | 0 | : | 3 |
| Group E |
May 27 • 02:30 | Corinthians | | - | | Club River Plate Asunción | 4 | : | 0 |
| Group E |
May 27 • 02:30 | Sport Huancayo | | - | | CA Peñarol | 0 | : | 0 |
| Group C |
May 28 • 00:15 | Club Jorge Wilstermann | | - | | Ceará SC | 1 | : | 0 |
| Group C |
May 28 • 00:15 | Arsenal de Sarandí | | - | | Club Bolívar | 3 | : | 1 |
| Group D |
May 28 • 02:30 | Club Athletico Paranaense | | - | | SD Aucas | 4 | : | 0 |
| Group D |
May 28 • 02:30 | FBC Melgar | | - | | Metropolitanos FC | 0 | : | 0 |
| Group H |
May 28 • 02:30 | CA Lanús | | - | | Aragua FC | 0 | : | 0 |
| Group H |
May 28 • 02:30 | La Equidad | | - | | Grêmio Porto Alegrense | 0 | : | 0 |
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| Jul 14 • 00:15 | LDU Quito |  | - | | Grêmio Porto Alegrense | 0 | : | 1 |
| Jul 14 • 02:30 | América de Cali |  | - | | Club Athletico Paranaense | 0 | : | 1 |
| Jul 15 • 00:15 | Sporting Cristal |  | - | | Arsenal de Sarandí | 2 | : | 1 |
| Jul 15 • 02:30 | Independiente del Valle |  | - | | RB Bragantino | 0 | : | 2 |
| Jul 15 • 02:30 | Atlético Junior |  | - | | Club Libertad | 3 | : | 4 |
| Jul 16 • 00:15 | Santos FC |  | - | | Independiente | 1 | : | 0 |
| Jul 16 • 02:30 | Club Nacional Montevideo |  | - | | CA Peñarol | 1 | : | 2 |
| Jul 16 • 02:30 | Deportivo Táchira |  | - | | Rosario Central | 2 | : | 2 |
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| Jul 21 • 00:15 | Grêmio Porto Alegrense | | - | | LDU Quito | 1 | : | 2 |
| Jul 21 • 02:30 | Club Athletico Paranaense | | - | | América de Cali | 4 | : | 1 |
| Jul 22 • 00:15 | Arsenal de Sarandí | | - | | Sporting Cristal | 1 | : | 1 |
| Jul 22 • 02:30 | RB Bragantino | | - | | Independiente del Valle | 1 | : | 1 |
| Jul 22 • 02:30 | Club Libertad | | - | | Atlético Junior | 0 | : | 1 |
| Jul 23 • 00:15 | Independiente | | - | | Santos FC | 1 | : | 1 |
| Jul 23 • 02:30 | CA Peñarol | | - | | Club Nacional Montevideo | 0 | : | 1 |
| Jul 23 • 02:30 | Rosario Central | | - | | Deportivo Táchira | 1 | : | 0 |
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| Aug 11 • 00:15 | Rosario Central | | - | | RB Bragantino | 3 | : | 4 |
| Aug 12 • 00:15 | Sporting Cristal | | - | | CA Peñarol | 1 | : | 3 |
| Aug 13 • 00:15 | LDU Quito | | - | | Club Athletico Paranaense | 1 | : | 0 |
| Aug 13 • 02:30 | Santos FC | | - | | Club Libertad | 2 | : | 1 |
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| Aug 18 • 00:15 | RB Bragantino | | - | | Rosario Central | 1 | : | 0 |
| Aug 19 • 00:15 | CA Peñarol | | - | | Sporting Cristal | 1 | : | 0 |
| Aug 20 • 00:15 | Club Athletico Paranaense | | - | | LDU Quito | 4 | : | 2 |
| Aug 20 • 02:30 | Club Libertad | | - | | Santos FC | 1 | : | 0 |
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| Sep 23 • 00:15 | RB Bragantino | | - | | Club Libertad | 2 | : | 0 |
| Sep 24 • 02:30 | CA Peñarol | | - | | Club Athletico Paranaense | 1 | : | 2 |
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| Sep 30 • 00:15 | Club Libertad | | - | | RB Bragantino | 1 | : | 3 |
| Oct 01 • 02:30 | Club Athletico Paranaense | | - | | CA Peñarol | 2 | : | 0 |
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| Nov 20 • 21:00 | Club Athletico Paranaense | | - | | RB Bragantino | 1 | : | 0 |
