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| Feb 21 • 23:00 | Club Nacional Asunción |  | - |  | Sporting Cristal | 2 | : | 0 |
| Feb 22 • 01:00 | Curicó Unido |  | - |  | Cerro Porteño | 0 | : | 1 |
| Feb 22 • 23:00 | El Nacional |  | - |  | Independiente Medellín | 2 | : | 2 |
| Feb 23 • 01:00 | Boston River |  | - |  | CA Huracán | 0 | : | 0 |
| Feb 23 • 01:30 | Carabobo FC |  | - |  | Atlético Mineiro | 0 | : | 0 |
| Feb 23 • 23:00 | Deportes Magallanes |  | - |  | Club Always Ready | 3 | : | 0 |
| Feb 24 • 01:00 | Deportivo Maldonado |  | - |  | Fortaleza EC | 0 | : | 0 |
| Feb 24 • 01:00 | Universidad Católica de Ecuador |  | - |  | Los Millonarios | 0 | : | 0 |
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| Feb 28 • 23:00 | Cerro Porteño | | - | | Curicó Unido | 1 | : | 0 |
| Mar 01 • 01:00 | Sporting Cristal | | - | | Club Nacional Asunción | 5 | : | 1 |
| Mar 01 • 23:00 | CA Huracán | | - | | Boston River | 1 | : | 0 |
| Mar 02 • 01:00 | Independiente Medellín | | - | | El Nacional | 2 | : | 1 |
| Mar 02 • 01:30 | Atlético Mineiro | | - | | Carabobo FC | 3 | : | 1 |
| Mar 02 • 23:00 | Club Always Ready | | - | | Deportes Magallanes | 1 | : | 3 |
| Mar 03 • 01:00 | Fortaleza EC | | - | | Deportivo Maldonado | 4 | : | 0 |
| Mar 03 • 01:00 | Los Millonarios | | - | | Universidad Católica de Ecuador | 2 | : | 1 |
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| Mar 08 • 23:00 | Deportes Magallanes | | - | | Independiente Medellín | 1 | : | 1 |
| Mar 09 • 01:30 | Los Millonarios | | - | | Atlético Mineiro | 1 | : | 1 |
| Mar 09 • 23:00 | Fortaleza EC | | - | | Cerro Porteño | 0 | : | 1 |
| Mar 10 • 01:00 | CA Huracán | | - | | Sporting Cristal | 0 | : | 0 |
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| Mar 16 • 01:00 | Independiente Medellín | | - | | Deportes Magallanes | 2 | : | 0 |
| Mar 16 • 01:30 | Atlético Mineiro | | - | | Los Millonarios | 3 | : | 1 |
| Mar 16 • 23:00 | Cerro Porteño | | - | | Fortaleza EC | 2 | : | 1 |
| Mar 17 • 01:00 | Sporting Cristal | | - | | CA Huracán | 1 | : | 0 |
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| Group D |
Apr 05 • 00:00 | The Strongest |  | - |  | River Plate | 3 | : | 1 |
| Group E |
Apr 05 • 00:00 | Argentinos Juniors |  | - |  | Independiente del Valle | 1 | : | 0 |
| Group G |
Apr 05 • 00:00 | Alianza Lima |  | - |  | Club Athletico Paranaense | 0 | : | 0 |
| Group B |
Apr 05 • 02:00 | Independiente Medellín | | - |  | SC Internacional | 1 | : | 1 |
| Group B |
Apr 05 • 04:00 | Metropolitanos FC |  | - |  | Club Nacional Montevideo | 1 | : | 2 |
| Group A |
Apr 06 • 00:00 | SD Aucas |  | - |  | Flamengo | 2 | : | 1 |
| Group H |
Apr 06 • 00:00 | Patronato de Paraná |  | - |  | Atlético Nacional | 1 | : | 2 |
| Group A |
Apr 06 • 02:00 | CD Ñublense |  | - |  | Racing Club | 0 | : | 2 |
| Group C |
Apr 06 • 02:00 | Cerro Porteño | | - |  | Barcelona SC | 2 | : | 1 |
| Group C |
Apr 06 • 02:30 | Club Bolívar |  | - |  | SE Palmeiras | 3 | : | 1 |
| Group D |
Apr 06 • 02:30 | Sporting Cristal | | - |  | Fluminense FC | 1 | : | 3 |
| Group F |
Apr 06 • 04:00 | Deportivo Pereira |  | - |  | Colo-Colo | 1 | : | 1 |
| Group E |
Apr 07 • 00:00 | Liverpool FC |  | - |  | Corinthians | 0 | : | 3 |
| Group G |
Apr 07 • 00:00 | Atlético Mineiro | | - |  | Club Libertad | 0 | : | 1 |
| Group F |
Apr 07 • 02:00 | Monagas SC |  | - |  | Boca Juniors | 0 | : | 0 |
| Group H |
Apr 07 • 02:00 | FBC Melgar |  | - |  | Olimpia Asunción | 1 | : | 1 |
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| Group B |
Apr 19 • 00:00 | SC Internacional | | - | | Metropolitanos FC | 1 | : | 0 |
| Group D |
Apr 19 • 00:00 | Fluminense FC | | - | | The Strongest | 1 | : | 0 |
| Group F |
Apr 19 • 02:00 | Boca Juniors | | - | | Deportivo Pereira | 2 | : | 1 |
| Group G |
Apr 19 • 02:00 | Club Athletico Paranaense | | - | | Atlético Mineiro | 2 | : | 1 |
| Group H |
Apr 19 • 02:00 | Olimpia Asunción | | - | | Patronato de Paraná | 1 | : | 0 |
| Group E |
Apr 19 • 04:00 | Independiente del Valle | | - | | Liverpool FC | 2 | : | 0 |
| Group B |
Apr 20 • 00:00 | Club Nacional Montevideo | | - | | Independiente Medellín | 2 | : | 1 |
| Group D |
Apr 20 • 02:00 | River Plate | | - | | Sporting Cristal | 4 | : | 2 |
| Group A |
Apr 20 • 02:30 | Flamengo | | - | | CD Ñublense | 2 | : | 0 |
| Group E |
Apr 20 • 02:30 | Corinthians | | - | | Argentinos Juniors | 0 | : | 1 |
| Group F |
Apr 20 • 03:00 | Colo-Colo | | - | | Monagas SC | 1 | : | 0 |
| Group C |
Apr 20 • 04:00 | Barcelona SC | | - | | Club Bolívar | 2 | : | 1 |
| Group A |
Apr 21 • 00:00 | Racing Club | | - | | SD Aucas | 3 | : | 2 |
| Group C |
Apr 21 • 02:00 | SE Palmeiras | | - | | Cerro Porteño | 2 | : | 1 |
| Group H |
Apr 21 • 02:00 | Atlético Nacional | | - | | FBC Melgar | 3 | : | 1 |
| Group G |
Apr 21 • 04:00 | Club Libertad | | - | | Alianza Lima | 1 | : | 2 |
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| Group A |
May 03 • 00:00 | CD Ñublense | | - | | SD Aucas | 2 | : | 1 |
| Group E |
May 03 • 00:00 | Liverpool FC | | - | | Argentinos Juniors | 2 | : | 2 |
| Group D |
May 03 • 02:00 | Fluminense FC | | - | | River Plate | 5 | : | 1 |
| Group E |
May 03 • 02:00 | Corinthians | | - | | Independiente del Valle | 1 | : | 2 |
| Group H |
May 03 • 02:00 | Atlético Nacional | | - | | Olimpia Asunción | 2 | : | 2 |
| Group D |
May 03 • 04:00 | Sporting Cristal | | - | | The Strongest | 1 | : | 0 |
| Group B |
May 04 • 00:00 | SC Internacional | | - | | Club Nacional Montevideo | 2 | : | 2 |
| Group C |
May 04 • 00:00 | Cerro Porteño | | - | | Club Bolívar | 0 | : | 4 |
| Group F |
May 04 • 02:00 | Colo-Colo | | - | | Boca Juniors | 0 | : | 2 |
| Group C |
May 04 • 02:30 | Barcelona SC | | - | | SE Palmeiras | 0 | : | 2 |
| Group G |
May 04 • 02:30 | Atlético Mineiro | | - | | Alianza Lima | 2 | : | 0 |
| Group B |
May 04 • 04:00 | Independiente Medellín | | - | | Metropolitanos FC | 4 | : | 2 |
| Group A |
May 05 • 00:00 | Racing Club | | - | | Flamengo | 1 | : | 1 |
| Group H |
May 05 • 00:00 | Patronato de Paraná | | - | | FBC Melgar | 4 | : | 1 |
| Group G |
May 05 • 02:00 | Club Libertad | | - | | Club Athletico Paranaense | 1 | : | 2 |
| Group F |
May 05 • 04:00 | Deportivo Pereira | | - | | Monagas SC | 2 | : | 1 |
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| Group F |
May 24 • 00:00 | Monagas SC | | - | | Colo-Colo | 1 | : | 1 |
| Group G |
May 24 • 00:00 | Atlético Mineiro | | - | | Club Athletico Paranaense | 2 | : | 1 |
| Group A |
May 24 • 02:00 | SD Aucas | | - | | Racing Club | 1 | : | 2 |
| Group B |
May 24 • 02:00 | Independiente Medellín | | - | | Club Nacional Montevideo | 2 | : | 1 |
| Group C |
May 24 • 02:00 | Club Bolívar | | - | | Barcelona SC | 1 | : | 0 |
| Group G |
May 24 • 04:00 | Alianza Lima | | - | | Club Libertad | 1 | : | 2 |
| Group C |
May 25 • 00:00 | Cerro Porteño | | - | | SE Palmeiras | 0 | : | 3 |
| Group E |
May 25 • 00:00 | Liverpool FC | | - | | Independiente del Valle | 1 | : | 0 |
| Group F |
May 25 • 02:00 | Deportivo Pereira | | - | | Boca Juniors | 1 | : | 0 |
| Group A |
May 25 • 02:30 | CD Ñublense | | - | | Flamengo | 1 | : | 1 |
| Group E |
May 25 • 02:30 | Argentinos Juniors | | - | | Corinthians | 0 | : | 0 |
| Group H |
May 25 • 04:00 | FBC Melgar | | - | | Atlético Nacional | 0 | : | 1 |
| Group D |
May 26 • 00:00 | The Strongest | | - | | Fluminense FC | 1 | : | 0 |
| Group H |
May 26 • 00:00 | Patronato de Paraná | | - | | Olimpia Asunción | 0 | : | 2 |
| Group B |
May 26 • 02:00 | Metropolitanos FC | | - | | SC Internacional | 1 | : | 2 |
| Group D |
May 26 • 02:00 | Sporting Cristal | | - | | River Plate | 1 | : | 1 |
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| Group F |
Jun 07 • 00:00 | Monagas SC | | - | | Deportivo Pereira | 1 | : | 0 |
| Group G |
Jun 07 • 00:00 | Club Athletico Paranaense | | - | | Club Libertad | 1 | : | 0 |
| Group F |
Jun 07 • 02:00 | Boca Juniors | | - | | Colo-Colo | 1 | : | 0 |
| Group G |
Jun 07 • 02:00 | Alianza Lima | | - | | Atlético Mineiro | 0 | : | 1 |
| Group H |
Jun 07 • 02:00 | FBC Melgar | | - | | Patronato de Paraná | 5 | : | 0 |
| Group C |
Jun 07 • 04:00 | Club Bolívar | | - | | Cerro Porteño | 2 | : | 0 |
| Group B |
Jun 08 • 00:00 | Club Nacional Montevideo | | - | | SC Internacional | 1 | : | 1 |
| Group E |
Jun 08 • 00:00 | Independiente del Valle | | - | | Corinthians | 3 | : | 0 |
| Group E |
Jun 08 • 00:00 | Argentinos Juniors | | - | | Liverpool FC | 2 | : | 1 |
| Group A |
Jun 08 • 02:00 | SD Aucas | | - | | CD Ñublense | 0 | : | 0 |
| Group C |
Jun 08 • 02:30 | SE Palmeiras | | - | | Barcelona SC | 4 | : | 2 |
| Group D |
Jun 08 • 02:30 | River Plate | | - | | Fluminense FC | 2 | : | 0 |
| Group D |
Jun 08 • 04:00 | The Strongest | | - | | Sporting Cristal | 1 | : | 2 |
| Group B |
Jun 09 • 00:00 | Metropolitanos FC | | - | | Independiente Medellín | 0 | : | 1 |
| Group A |
Jun 09 • 02:00 | Flamengo | | - | | Racing Club | 2 | : | 1 |
| Group H |
Jun 09 • 02:00 | Olimpia Asunción | | - | | Atlético Nacional | 3 | : | 0 |
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| Group G |
Jun 28 • 00:00 | Club Athletico Paranaense | | - | | Alianza Lima | 3 | : | 0 |
| Group G |
Jun 28 • 00:00 | Club Libertad | | - | | Atlético Mineiro | 1 | : | 1 |
| Group D |
Jun 28 • 02:00 | River Plate | | - | | The Strongest | 2 | : | 0 |
| Group D |
Jun 28 • 02:00 | Fluminense FC | | - | | Sporting Cristal | 1 | : | 1 |
| Group H |
Jun 28 • 02:00 | Olimpia Asunción | | - | | FBC Melgar | 4 | : | 1 |
| Group H |
Jun 28 • 02:00 | Atlético Nacional | | - | | Patronato de Paraná | 0 | : | 1 |
| Group B |
Jun 29 • 00:00 | Club Nacional Montevideo | | - | | Metropolitanos FC | 1 | : | 0 |
| Group B |
Jun 29 • 00:00 | SC Internacional | | - | | Independiente Medellín | 3 | : | 1 |
| Group A |
Jun 29 • 02:30 | Flamengo | | - | | SD Aucas | 4 | : | 0 |
| Group A |
Jun 29 • 02:30 | Racing Club | | - | | CD Ñublense | 4 | : | 0 |
| Group E |
Jun 29 • 02:30 | Independiente del Valle | | - | | Argentinos Juniors | 3 | : | 2 |
| Group E |
Jun 29 • 02:30 | Corinthians | | - | | Liverpool FC | 3 | : | 0 |
| Group F |
Jun 30 • 00:00 | Boca Juniors | | - | | Monagas SC | 4 | : | 0 |
| Group F |
Jun 30 • 00:00 | Colo-Colo | | - | | Deportivo Pereira | 0 | : | 0 |
| Group C |
Jun 30 • 02:00 | SE Palmeiras | | - | | Club Bolívar | 4 | : | 0 |
| Group C |
Jun 30 • 02:00 | Barcelona SC | | - | | Cerro Porteño | 2 | : | 2 |
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| Aug 02 • 00:00 | Argentinos Juniors | | - | | Fluminense FC | 1 | : | 1 |
| Aug 02 • 02:00 | River Plate | | - | | SC Internacional | 2 | : | 1 |
| Aug 02 • 02:00 | Club Bolívar | | - | | Club Athletico Paranaense | 3 | : | 1 |
| Aug 03 • 02:00 | Deportivo Pereira | | - | | Independiente del Valle | 1 | : | 0 |
| Aug 03 • 02:00 | Club Nacional Montevideo | | - | | Boca Juniors | 0 | : | 0 |
| Aug 03 • 02:30 | Atlético Mineiro | | - | | SE Palmeiras | 0 | : | 1 |
| Aug 04 • 02:00 | Atlético Nacional | | - | | Racing Club | 4 | : | 2 |
| Aug 04 • 02:00 | Flamengo | | - | | Olimpia Asunción | 1 | : | 0 |
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| Aug 09 • 00:00 | Fluminense FC | | - | | Argentinos Juniors | 2 | : | 0 |
| Aug 09 • 02:00 | SC Internacional | | - | | River Plate | 2 | : | 1 |
| Aug 09 • 02:00 | Club Athletico Paranaense | | - | | Club Bolívar | 2 | : | 0 |
| Aug 10 • 02:00 | Independiente del Valle | | - | | Deportivo Pereira | 1 | : | 1 |
| Aug 10 • 02:00 | Boca Juniors | | - | | Club Nacional Montevideo | 2 | : | 2 |
| Aug 10 • 02:30 | SE Palmeiras | | - | | Atlético Mineiro | 0 | : | 0 |
| Aug 11 • 02:00 | Racing Club | | - | | Atlético Nacional | 3 | : | 0 |
| Aug 11 • 02:00 | Olimpia Asunción | | - | | Flamengo | 3 | : | 1 |
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| Aug 23 • 00:00 | Club Bolívar | | - | | SC Internacional | 0 | : | 1 |
| Aug 24 • 02:30 | Boca Juniors | | - | | Racing Club | 0 | : | 0 |
| Aug 24 • 02:30 | Deportivo Pereira | | - | | SE Palmeiras | 0 | : | 4 |
| Aug 25 • 02:30 | Fluminense FC | | - | | Olimpia Asunción | 2 | : | 0 |
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| Aug 30 • 00:00 | SC Internacional | | - | | Club Bolívar | 2 | : | 0 |
| Aug 31 • 02:30 | Racing Club | | - | | Boca Juniors | 0 | : | 0 |
| Aug 31 • 02:30 | SE Palmeiras | | - | | Deportivo Pereira | 0 | : | 0 |
| Sep 01 • 02:30 | Olimpia Asunción | | - | | Fluminense FC | 1 | : | 3 |
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| Sep 28 • 02:30 | Fluminense FC | | - | | SC Internacional | 2 | : | 2 |
| Sep 29 • 02:30 | Boca Juniors | | - | | SE Palmeiras | 0 | : | 0 |
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| Oct 05 • 02:30 | SC Internacional | | - | | Fluminense FC | 1 | : | 2 |
| Oct 06 • 02:30 | SE Palmeiras | | - | | Boca Juniors | 1 | : | 1 |
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| Nov 04 • 21:00 | Boca Juniors | | - | | Fluminense FC | 1 | : | 2 |
