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| Mar 05 • 23:00 | Real Tomayapo |  | - |  | Club Jorge Wilstermann | 0 | : | 0 |
| Mar 05 • 23:00 | CD Universidad Católica |  | - |  | Coquimbo Unido | 0 | : | 2 |
| Mar 06 • 01:30 | Deportivo Garcilaso |  | - |  | Asociación Deportiva Tarma | 0 | : | 0 |
| Mar 06 • 01:30 | Carabobo FC |  | - |  | Metropolitanos FC | 1 | : | 1 |
| Mar 06 • 03:00 | Deportes Tolima |  | - |  | Independiente Medellín | 0 | : | 0 |
| Mar 06 • 23:00 | Universitario de Vinto |  | - |  | Nacional Potosí | 0 | : | 2 |
| Mar 06 • 23:00 | Everton Viña del Mar |  | - |  | Unión La Calera | 0 | : | 1 |
| Mar 07 • 01:30 | Deportivo Cuenca |  | - |  | Delfín SC | 2 | : | 5 |
| Mar 07 • 01:30 | Club Guaraní |  | - |  | Sportivo Luqueño | 0 | : | 1 |
| Mar 07 • 01:30 | Montevideo Wanderers |  | - |  | Danubio FC | 0 | : | 1 |
| Mar 07 • 03:00 | Alianza Petrolera |  | - |  | América de Cali | 2 | : | 1 |
| Mar 07 • 23:00 | Racing Club de Montevideo |  | - |  | Cerro Largo FC | 2 | : | 0 |
| Mar 07 • 23:00 | Deportivo Rayo Zuliano |  | - |  | Deportivo La Guaira | 0 | : | 0 |
| Mar 08 • 01:30 | Sportivo Ameliano |  | - |  | Olimpia Asunción | 2 | : | 0 |
| Mar 08 • 01:30 | Universidad César Vallejo |  | - |  | Sport Huancayo | 2 | : | 0 |
| Mar 08 • 03:00 | Técnico Universitario |  | - |  | Universidad Católica de Ecuador | 0 | : | 3 |
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| Group C |
Apr 03 • 00:00 | CA Belgrano |  | - |  | SC Internacional | 0 | : | 0 |
| Group F |
Apr 03 • 00:00 | Club Nacional Asunción |  | - |  | Argentinos Juniors | 2 | : | 3 |
| Group E |
Apr 03 • 02:30 | Sportivo Ameliano | | - |  | Club Athletico Paranaense | 1 | : | 4 |
| Group F |
Apr 03 • 02:30 | Racing Club de Montevideo | | - |  | Corinthians | 1 | : | 1 |
| Group A |
Apr 03 • 04:00 | Universidad César Vallejo | | - |  | Defensa y Justicia | 0 | : | 1 |
| Group E |
Apr 04 • 00:00 | Deportivo Rayo Zuliano | | - | | Danubio FC | 0 | : | 2 |
| Group G |
Apr 04 • 00:00 | Cuiabá EC |  | - |  | CA Lanús | 1 | : | 1 |
| Group D |
Apr 04 • 02:00 | Nacional Potosí | | - |  | Boca Juniors | 0 | : | 0 |
| Group D |
Apr 04 • 02:00 | Sportivo Trinidense |  | - |  | Fortaleza EC | 0 | : | 2 |
| Group H |
Apr 04 • 02:00 | RB Bragantino |  | - | | Coquimbo Unido | 1 | : | 0 |
| Group B |
Apr 04 • 04:00 | Alianza Petrolera | | - | | Unión La Calera | 0 | : | 1 |
| Group G |
Apr 05 • 00:00 | Deportivo Garcilaso | | - | | Metropolitanos FC | 3 | : | 2 |
| Group B |
Apr 05 • 02:00 | Universidad Católica de Ecuador | | - |  | Cruzeiro EC | 0 | : | 0 |
| Group H |
Apr 05 • 02:00 | Sportivo Luqueño | | - |  | Racing Club | 0 | : | 2 |
| Group A |
Apr 05 • 04:00 | Club Always Ready |  | - | | Independiente Medellín | 2 | : | 0 |
| Group C |
Apr 05 • 04:00 | Real Tomayapo | | - | | Delfín SC | 0 | : | 1 |
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| Group F |
Apr 10 • 00:00 | Argentinos Juniors | | - | | Racing Club de Montevideo | 0 | : | 3 |
| Group F |
Apr 10 • 00:00 | Corinthians | | - | | Club Nacional Asunción | 4 | : | 0 |
| Group D |
Apr 10 • 02:00 | Boca Juniors | | - | | Sportivo Trinidense | 1 | : | 0 |
| Group E |
Apr 10 • 02:30 | Danubio FC | | - | | Sportivo Ameliano | 0 | : | 0 |
| Group E |
Apr 10 • 02:30 | Club Athletico Paranaense | | - | | Deportivo Rayo Zuliano | 6 | : | 0 |
| Group A |
Apr 11 • 00:00 | Defensa y Justicia | | - | | Club Always Ready | 1 | : | 1 |
| Group D |
Apr 11 • 00:00 | Fortaleza EC | | - | | Nacional Potosí | 5 | : | 0 |
| Group B |
Apr 11 • 02:00 | Unión La Calera | | - | | Universidad Católica de Ecuador | 0 | : | 1 |
| Group C |
Apr 11 • 02:00 | SC Internacional | | - | | Real Tomayapo | 0 | : | 0 |
| Group H |
Apr 11 • 02:30 | Racing Club | | - | | RB Bragantino | 3 | : | 0 |
| Group A |
Apr 11 • 04:00 | Independiente Medellín | | - | | Universidad César Vallejo | 4 | : | 2 |
| Group G |
Apr 12 • 00:00 | CA Lanús | | - | | Deportivo Garcilaso | 2 | : | 1 |
| Group G |
Apr 12 • 00:00 | Metropolitanos FC | | - | | Cuiabá EC | 0 | : | 2 |
| Group B |
Apr 12 • 02:00 | Cruzeiro EC | | - | | Alianza Petrolera | 3 | : | 3 |
| Group H |
Apr 12 • 02:00 | Coquimbo Unido | | - | | Sportivo Luqueño | 1 | : | 0 |
| Group C |
Apr 12 • 04:00 | Delfín SC | | - | | CA Belgrano | 1 | : | 1 |
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| Group B |
Apr 24 • 00:00 | Unión La Calera | | - | | Cruzeiro EC | 0 | : | 0 |
| Group D |
Apr 24 • 02:00 | Sportivo Trinidense | | - | | Nacional Potosí | 2 | : | 0 |
| Group G |
Apr 24 • 02:00 | Deportivo Garcilaso | | - | | Cuiabá EC | 1 | : | 1 |
| Group F |
Apr 24 • 02:30 | Argentinos Juniors | | - | | Corinthians | 1 | : | 0 |
| Group B |
Apr 24 • 04:00 | Alianza Petrolera | | - | | Universidad Católica de Ecuador | 1 | : | 3 |
| Group E |
Apr 25 • 00:00 | Danubio FC | | - | | Club Athletico Paranaense | 0 | : | 1 |
| Group H |
Apr 25 • 00:00 | Coquimbo Unido | | - | | Racing Club | 1 | : | 2 |
| Group H |
Apr 25 • 02:00 | RB Bragantino | | - | | Sportivo Luqueño | 2 | : | 1 |
| Group C |
Apr 25 • 02:30 | Real Tomayapo | | - | | CA Belgrano | 0 | : | 2 |
| Group E |
Apr 25 • 04:00 | Deportivo Rayo Zuliano | | - | | Sportivo Ameliano | 0 | : | 4 |
| Group F |
Apr 26 • 00:00 | Club Nacional Asunción | | - | | Racing Club de Montevideo | 2 | : | 2 |
| Group G |
Apr 26 • 00:00 | Metropolitanos FC | | - | | CA Lanús | 0 | : | 2 |
| Group A |
Apr 26 • 02:00 | Club Always Ready | | - | | Universidad César Vallejo | 2 | : | 0 |
| Group D |
Apr 26 • 02:00 | Fortaleza EC | | - | | Boca Juniors | 4 | : | 2 |
| Group A |
Apr 26 • 04:00 | Independiente Medellín | | - | | Defensa y Justicia | 2 | : | 1 |
| Group C |
Apr 26 • 04:00 | Delfín SC | | - | | SC Internacional | 1 | : | 2 |
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| Group F |
May 08 • 00:00 | Club Nacional Asunción | | - | | Corinthians | 0 | : | 2 |
| Group F |
May 08 • 00:00 | Racing Club de Montevideo | | - | | Argentinos Juniors | 2 | : | 1 |
| Group A |
May 08 • 02:00 | Universidad César Vallejo | | - | | Independiente Medellín | 1 | : | 5 |
| Group B |
May 08 • 02:30 | Alianza Petrolera | | - | | Cruzeiro EC | 0 | : | 3 |
| Group E |
May 08 • 02:30 | Sportivo Ameliano | | - | | Danubio FC | 2 | : | 1 |
| Group A |
May 08 • 04:00 | Club Always Ready | | - | | Defensa y Justicia | 3 | : | 0 |
| Group E |
May 09 • 00:00 | Deportivo Rayo Zuliano | | - | | Club Athletico Paranaense | 1 | : | 5 |
| Group H |
May 09 • 00:00 | Sportivo Luqueño | | - | | Coquimbo Unido | 0 | : | 0 |
| Group D |
May 09 • 02:00 | Nacional Potosí | | - | | Fortaleza EC | 4 | : | 1 |
| Group G |
May 09 • 02:00 | Cuiabá EC | | - | | Metropolitanos FC | 3 | : | 0 |
| Group D |
May 09 • 02:30 | Sportivo Trinidense | | - | | Boca Juniors | 1 | : | 2 |
| Group C |
May 10 • 00:00 | CA Belgrano | | - | | Delfín SC | 1 | : | 1 |
| Group H |
May 10 • 02:00 | RB Bragantino | | - | | Racing Club | 2 | : | 1 |
| Group B |
May 10 • 04:00 | Universidad Católica de Ecuador | | - | | Unión La Calera | 3 | : | 0 |
| Group G |
May 10 • 04:00 | Deportivo Garcilaso | | - | | CA Lanús | 0 | : | 2 |
| Group C |
Jun 05 • 02:30 | Real Tomayapo | | - | | SC Internacional | 0 | : | 2 |
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| Group F |
May 15 • 00:00 | Racing Club de Montevideo | | - | | Club Nacional Asunción | 2 | : | 1 |
| Group A |
May 15 • 02:00 | Defensa y Justicia | | - | | Independiente Medellín | 1 | : | 1 |
| Group E |
May 15 • 02:00 | Sportivo Ameliano | | - | | Deportivo Rayo Zuliano | 1 | : | 0 |
| Group F |
May 15 • 02:30 | Corinthians | | - | | Argentinos Juniors | 4 | : | 0 |
| Group D |
May 15 • 04:00 | Nacional Potosí | | - | | Sportivo Trinidense | 2 | : | 1 |
| Group C |
May 16 • 00:00 | CA Belgrano | | - | | Real Tomayapo | 1 | : | 0 |
| Group E |
May 16 • 00:00 | Club Athletico Paranaense | | - | | Danubio FC | 1 | : | 2 |
| Group G |
May 16 • 00:00 | CA Lanús | | - | | Metropolitanos FC | 5 | : | 0 |
| Group D |
May 16 • 02:00 | Boca Juniors | | - | | Fortaleza EC | 1 | : | 1 |
| Group G |
May 16 • 02:00 | Cuiabá EC | | - | | Deportivo Garcilaso | 1 | : | 1 |
| Group A |
May 16 • 04:00 | Universidad César Vallejo | | - | | Club Always Ready | 2 | : | 2 |
| Group H |
May 17 • 00:00 | Racing Club | | - | | Coquimbo Unido | 3 | : | 0 |
| Group B |
May 17 • 02:00 | Cruzeiro EC | | - | | Unión La Calera | 1 | : | 0 |
| Group H |
May 17 • 02:00 | Sportivo Luqueño | | - | | RB Bragantino | 2 | : | 3 |
| Group B |
May 17 • 04:00 | Universidad Católica de Ecuador | | - | | Alianza Petrolera | 0 | : | 0 |
| Group C |
Jun 09 • 02:30 | SC Internacional | | - | | Delfín SC | 1 | : | 0 |
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| Group F |
May 29 • 00:00 | Argentinos Juniors | | - | | Club Nacional Asunción | 2 | : | 1 |
| Group F |
May 29 • 00:00 | Corinthians | | - | | Racing Club de Montevideo | 3 | : | 0 |
| Group C |
May 29 • 02:30 | Delfín SC | | - | | Real Tomayapo | 4 | : | 3 |
| Group C |
May 29 • 02:30 | SC Internacional | | - | | CA Belgrano | 1 | : | 2 |
| Group H |
May 29 • 02:30 | Coquimbo Unido | | - | | RB Bragantino | 1 | : | 1 |
| Group H |
May 29 • 02:30 | Racing Club | | - | | Sportivo Luqueño | 3 | : | 0 |
| Group G |
May 30 • 00:00 | CA Lanús | | - | | Cuiabá EC | 0 | : | 1 |
| Group G |
May 30 • 00:00 | Metropolitanos FC | | - | | Deportivo Garcilaso | 1 | : | 1 |
| Group A |
May 30 • 02:00 | Defensa y Justicia | | - | | Universidad César Vallejo | 0 | : | 1 |
| Group A |
May 30 • 02:00 | Independiente Medellín | | - | | Club Always Ready | 4 | : | 0 |
| Group D |
May 30 • 02:00 | Boca Juniors | | - | | Nacional Potosí | 4 | : | 0 |
| Group D |
May 30 • 02:00 | Fortaleza EC | | - | | Sportivo Trinidense | 2 | : | 1 |
| Group E |
May 31 • 00:00 | Club Athletico Paranaense | | - | | Sportivo Ameliano | 0 | : | 1 |
| Group E |
May 31 • 00:00 | Danubio FC | | - | | Deportivo Rayo Zuliano | 0 | : | 0 |
| Group B |
May 31 • 02:00 | Cruzeiro EC | | - | | Universidad Católica de Ecuador | 1 | : | 0 |
| Group B |
May 31 • 02:00 | Unión La Calera | | - | | Alianza Petrolera | 0 | : | 1 |
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| Jul 17 • 00:00 | CD Huachipato |  | - | | Racing Club de Montevideo | 2 | : | 3 |
| Jul 17 • 02:30 | Rosario Central |  | - | | SC Internacional | 1 | : | 0 |
| Jul 18 • 00:00 | Club Libertad |  | - | | Universidad Católica de Ecuador | 2 | : | 0 |
| Jul 18 • 02:30 | Barcelona SC |  | - | | RB Bragantino | 1 | : | 1 |
| Jul 18 • 02:30 | Independiente del Valle |  | - | | Boca Juniors | 0 | : | 0 |
| Jul 19 • 00:00 | CD Palestino |  | - | | Cuiabá EC | 1 | : | 1 |
| Jul 19 • 02:30 | Cerro Porteño |  | - | | Club Athletico Paranaense | 1 | : | 1 |
| Jul 19 • 02:30 | LDU Quito |  | - | | Club Always Ready | 3 | : | 0 |
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| Jul 24 • 00:00 | Racing Club de Montevideo | | - | | CD Huachipato | 0 | : | 1 |
| Jul 24 • 02:30 | SC Internacional | | - | | Rosario Central | 1 | : | 1 |
| Jul 25 • 00:00 | Universidad Católica de Ecuador | | - | | Club Libertad | 1 | : | 1 |
| Jul 25 • 02:30 | Boca Juniors | | - | | Independiente del Valle | 1 | : | 0 |
| Jul 25 • 02:30 | RB Bragantino | | - | | Barcelona SC | 3 | : | 2 |
| Jul 26 • 00:00 | Cuiabá EC | | - | | CD Palestino | 1 | : | 2 |
| Jul 26 • 02:30 | Club Always Ready | | - | | LDU Quito | 3 | : | 1 |
| Jul 26 • 02:30 | Club Athletico Paranaense | | - | | Cerro Porteño | 2 | : | 1 |
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| Aug 14 • 00:00 | CD Huachipato | | - | | Racing Club | 0 | : | 2 |
| Aug 14 • 02:30 | RB Bragantino | | - | | Corinthians | 1 | : | 2 |
| Aug 15 • 00:00 | Rosario Central | | - | | Fortaleza EC | 1 | : | 1 |
| Aug 15 • 02:30 | LDU Quito | | - | | CA Lanús | 1 | : | 2 |
| Aug 15 • 02:30 | CD Palestino | | - | | Independiente Medellín | 2 | : | 2 |
| Aug 16 • 00:00 | Club Libertad | | - | | Sportivo Ameliano | 1 | : | 1 |
| Aug 16 • 00:00 | Club Athletico Paranaense | | - | | CA Belgrano | 2 | : | 1 |
| Aug 16 • 02:30 | Boca Juniors | | - | | Cruzeiro EC | 1 | : | 0 |
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| Aug 21 • 00:00 | Racing Club | | - | | CD Huachipato | 6 | : | 1 |
| Aug 21 • 02:30 | Corinthians | | - | | RB Bragantino | 1 | : | 2 |
| Aug 22 • 00:00 | Fortaleza EC | | - | | Rosario Central | 3 | : | 1 |
| Aug 22 • 02:30 | CA Lanús | | - | | LDU Quito | 3 | : | 1 |
| Aug 22 • 02:30 | Independiente Medellín | | - | | CD Palestino | 4 | : | 0 |
| Aug 23 • 00:00 | Sportivo Ameliano | | - | | Club Libertad | 0 | : | 0 |
| Aug 23 • 00:00 | CA Belgrano | | - | | Club Athletico Paranaense | 0 | : | 2 |
| Aug 23 • 02:30 | Cruzeiro EC | | - | | Boca Juniors | 2 | : | 1 |
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| Sep 18 • 02:30 | Fortaleza EC | | - | | Corinthians | 0 | : | 2 |
| Sep 19 • 02:30 | CA Lanús | | - | | Independiente Medellín | 0 | : | 0 |
| Sep 20 • 02:30 | Club Libertad | | - | | Cruzeiro EC | 0 | : | 2 |
| Sep 20 • 02:30 | Club Athletico Paranaense | | - | | Racing Club | 1 | : | 0 |
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| Sep 25 • 02:30 | Corinthians | | - | | Fortaleza EC | 3 | : | 0 |
| Sep 26 • 02:30 | Independiente Medellín | | - | | CA Lanús | 1 | : | 1 |
| Sep 27 • 02:30 | Cruzeiro EC | | - | | Club Libertad | 1 | : | 1 |
| Sep 27 • 02:30 | Racing Club | | - | | Club Athletico Paranaense | 4 | : | 1 |
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| Oct 24 • 00:00 | Cruzeiro EC | | - | | CA Lanús | 1 | : | 1 |
| Oct 25 • 02:30 | Corinthians | | - | | Racing Club | 2 | : | 2 |
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| Oct 30 • 23:00 | CA Lanús | | - | | Cruzeiro EC | 0 | : | 1 |
| Nov 01 • 01:30 | Racing Club | | - | | Corinthians | 2 | : | 1 |
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| Nov 23 • 21:00 | Racing Club | | - | | Cruzeiro EC | 3 | : | 1 |
