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| Jan 27 • 00:10 | Colón de Santa Fe |  | - |  | CD Universidad Católica | 3 | : | 2 |
| Jan 27 • 02:30 | Deportivo Táchira |  | - |  | Club Libertad | 1 | : | 0 |
| Jan 27 • 22:30 | Newell's Old Boys |  | - |  | CS Emelec | 0 | : | 0 |
| Jan 28 • 00:50 | Real Potosí |  | - |  | Cruzeiro EC | 1 | : | 1 |
| Jan 28 • 02:10 | Juan Aurich |  | - |  | Estudiantes Tecos | 2 | : | 0 |
| Jan 29 • 00:10 | Atlético Junior |  | - |  | Racing Club de Montevideo | 2 | : | 2 |
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| Feb 03 • 00:10 | Club Libertad | | - | | Deportivo Táchira | 3 | : | 1 |
| Feb 04 • 00:50 | Cruzeiro EC | | - | | Real Potosí | 7 | : | 0 |
| Feb 04 • 03:20 | Estudiantes Tecos | | - | | Juan Aurich | 1 | : | 2 |
| Feb 05 • 00:10 | Racing Club de Montevideo | | - | | Atlético Junior | 2 | : | 0 |
| Feb 09 • 23:20 | CD Universidad Católica | | - | | Colón de Santa Fe | 8 | : | 5 |
| Feb 11 • 03:10 | CS Emelec | | - | | Newell's Old Boys | 2 | : | 1 |
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| Group E |
Feb 09 • 21:10 | CA Cerro |  | - |  | Deportivo Quito | 2 | : | 0 |
| Group B |
Feb 09 • 23:20 | Club Nacional Asunción |  | - |  | Once Caldas | 0 | : | 2 |
| Group D |
Feb 10 • 01:40 | CA Lanús |  | - | | Club Libertad | 0 | : | 2 |
| Group C |
Feb 10 • 22:30 | Club Bolívar |  | - |  | Alianza Lima | 1 | : | 3 |
| Group F |
Feb 10 • 22:30 | CA Banfield |  | - |  | Monarcas Morelia | 2 | : | 1 |
| Group B |
Feb 11 • 00:50 | São Paulo FC |  | - |  | CF Monterrey | 2 | : | 0 |
| Group G |
Feb 11 • 00:50 | Vélez Sársfield |  | - | | Cruzeiro EC | 2 | : | 0 |
| Group F |
Feb 11 • 22:00 | Club Nacional Montevideo |  | - |  | Deportivo Cuenca | 3 | : | 2 |
| Group A |
Feb 12 • 00:15 | Cerro Porteño |  | - |  | Independiente Medellín | 1 | : | 1 |
| Group C |
Feb 12 • 00:15 | Estudiantes de La Plata |  | - | | Juan Aurich | 5 | : | 1 |
| Group D |
Feb 12 • 02:30 | Club Blooming |  | - |  | Universitario de Deportes | 1 | : | 2 |
| Group G |
Feb 16 • 23:00 | Colo-Colo |  | - |  | Deportivo Italia | 1 | : | 0 |
| Group H |
Feb 18 • 23:15 | Universidad de Chile |  | - |  | Caracas FC | 1 | : | 0 |
| Group E |
Feb 24 • 00:50 | SC Internacional |  | - | | CS Emelec | 2 | : | 1 |
| Group A |
Feb 25 • 01:50 | Corinthians |  | - | | Racing Club de Montevideo | 2 | : | 1 |
| Group H |
Feb 25 • 01:50 | Flamengo |  | - | | CD Universidad Católica | 2 | : | 0 |
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| Group D |
Feb 17 • 01:15 | Club Libertad | | - | | Club Blooming | 4 | : | 0 |
| Group F |
Feb 18 • 01:15 | Deportivo Cuenca | | - | | CA Banfield | 1 | : | 4 |
| Group D |
Feb 18 • 03:30 | Universitario de Deportes | | - | | CA Lanús | 2 | : | 0 |
| Group C |
Feb 19 • 01:30 | Alianza Lima | | - | | Estudiantes de La Plata | 4 | : | 1 |
| Group G |
Feb 23 • 23:30 | Deportivo Italia | | - | | Vélez Sársfield | 0 | : | 1 |
| Group F |
Feb 24 • 04:10 | Monarcas Morelia | | - | | Club Nacional Montevideo | 0 | : | 0 |
| Group C |
Feb 24 • 23:30 | Juan Aurich | | - | | Club Bolívar | 2 | : | 0 |
| Group G |
Feb 24 • 23:30 | Cruzeiro EC | | - | | Colo-Colo | 4 | : | 1 |
| Group B |
Feb 25 • 04:10 | CF Monterrey | | - | | Club Nacional Asunción | 2 | : | 1 |
| Group B |
Feb 26 • 01:10 | Once Caldas | | - | | São Paulo FC | 2 | : | 1 |
| Group A |
Mar 09 • 23:00 | Racing Club de Montevideo | | - | | Cerro Porteño | 2 | : | 1 |
| Group H |
Mar 10 • 01:15 | CD Universidad Católica | | - | | Universidad de Chile | 2 | : | 2 |
| Group A |
Mar 11 • 01:50 | Independiente Medellín | | - | | Corinthians | 1 | : | 1 |
| Group H |
Mar 11 • 01:50 | Caracas FC | | - | | Flamengo | 1 | : | 3 |
| Group E |
Mar 12 • 01:15 | CS Emelec | | - | | CA Cerro | 1 | : | 2 |
| Group E |
Mar 12 • 03:30 | Deportivo Quito | | - | | SC Internacional | 1 | : | 1 |
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| Group D |
Feb 25 • 23:00 | Club Blooming | | - | | CA Lanús | 1 | : | 4 |
| Group D |
Feb 26 • 03:20 | Universitario de Deportes | | - | | Club Libertad | 0 | : | 0 |
| Group C |
Mar 09 • 23:00 | Club Bolívar | | - | | Estudiantes de La Plata | 0 | : | 0 |
| Group F |
Mar 10 • 03:30 | Deportivo Cuenca | | - | | Monarcas Morelia | 2 | : | 0 |
| Group B |
Mar 10 • 23:30 | Once Caldas | | - | | CF Monterrey | 1 | : | 1 |
| Group F |
Mar 10 • 23:30 | Club Nacional Montevideo | | - | | CA Banfield | 2 | : | 2 |
| Group C |
Mar 11 • 01:50 | Alianza Lima | | - | | Juan Aurich | 2 | : | 0 |
| Group B |
Mar 11 • 23:00 | Club Nacional Asunción | | - | | São Paulo FC | 0 | : | 2 |
| Group G |
Mar 12 • 01:15 | Deportivo Italia | | - | | Cruzeiro EC | 2 | : | 2 |
| Group G |
Mar 17 • 01:00 | Colo-Colo | | - | | Vélez Sársfield | 1 | : | 1 |
| Group H |
Mar 17 • 23:30 | Caracas FC | | - | | CD Universidad Católica | 0 | : | 0 |
| Group H |
Mar 18 • 00:50 | Universidad de Chile | | - | | Flamengo | 2 | : | 1 |
| Group A |
Mar 18 • 01:50 | Cerro Porteño | | - | | Corinthians | 0 | : | 1 |
| Group E |
Mar 18 • 23:15 | CA Cerro | | - | | SC Internacional | 0 | : | 0 |
| Group A |
Mar 19 • 03:45 | Independiente Medellín | | - | | Racing Club de Montevideo | 0 | : | 0 |
| Group E |
Mar 26 • 01:15 | Deportivo Quito | | - | | CS Emelec | 1 | : | 0 |
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| Group F |
Mar 16 • 23:30 | CA Banfield | | - | | Club Nacional Montevideo | 0 | : | 2 |
| Group C |
Mar 17 • 02:00 | Juan Aurich | | - | | Alianza Lima | 4 | : | 2 |
| Group F |
Mar 17 • 04:15 | Monarcas Morelia | | - | | Deportivo Cuenca | 2 | : | 1 |
| Group B |
Mar 18 • 04:15 | CF Monterrey | | - | | Once Caldas | 2 | : | 2 |
| Group B |
Mar 19 • 01:30 | São Paulo FC | | - | | Club Nacional Asunción | 3 | : | 0 |
| Group C |
Mar 23 • 23:30 | Estudiantes de La Plata | | - | | Club Bolívar | 2 | : | 0 |
| Group D |
Mar 24 • 01:45 | Club Libertad | | - | | Universitario de Deportes | 1 | : | 1 |
| Group D |
Mar 24 • 23:30 | CA Lanús | | - | | Club Blooming | 1 | : | 0 |
| Group H |
Mar 24 • 23:30 | CD Universidad Católica | | - | | Caracas FC | 1 | : | 1 |
| Group G |
Mar 25 • 01:50 | Cruzeiro EC | | - | | Deportivo Italia | 2 | : | 0 |
| Group G |
Mar 25 • 23:00 | Vélez Sársfield | | - | | Colo-Colo | 2 | : | 1 |
| Group A |
Mar 26 • 01:15 | Racing Club de Montevideo | | - | | Independiente Medellín | 1 | : | 0 |
| Group E |
Apr 01 • 02:50 | SC Internacional | | - | | CA Cerro | 2 | : | 0 |
| Group A |
Apr 02 • 00:15 | Corinthians | | - | | Cerro Porteño | 2 | : | 1 |
| Group E |
Apr 02 • 02:30 | CS Emelec | | - | | Deportivo Quito | 0 | : | 1 |
| Group H |
Apr 08 • 21:00 | Flamengo | | - | | Universidad de Chile | 2 | : | 2 |
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| Group D |
Mar 31 • 01:15 | Club Libertad | | - | | CA Lanús | 1 | : | 1 |
| Group C |
Mar 31 • 03:30 | Juan Aurich | | - | | Estudiantes de La Plata | 0 | : | 2 |
| Group G |
Apr 01 • 00:30 | Cruzeiro EC | | - | | Vélez Sársfield | 3 | : | 0 |
| Group B |
Apr 01 • 02:50 | CF Monterrey | | - | | São Paulo FC | 0 | : | 0 |
| Group F |
Apr 01 • 05:10 | Monarcas Morelia | | - | | CA Banfield | 1 | : | 1 |
| Group B |
Apr 02 • 04:45 | Once Caldas | | - | | Club Nacional Asunción | 1 | : | 0 |
| Group G |
Apr 07 • 01:15 | Deportivo Italia | | - | | Colo-Colo | 2 | : | 3 |
| Group D |
Apr 07 • 03:30 | Universitario de Deportes | | - | | Club Blooming | 0 | : | 0 |
| Group F |
Apr 08 • 00:30 | Deportivo Cuenca | | - | | Club Nacional Montevideo | 0 | : | 0 |
| Group A |
Apr 09 • 01:15 | Independiente Medellín | | - | | Cerro Porteño | 1 | : | 0 |
| Group C |
Apr 09 • 03:30 | Alianza Lima | | - | | Club Bolívar | 1 | : | 0 |
| Group E |
Apr 14 • 01:15 | Deportivo Quito | | - | | CA Cerro | 2 | : | 1 |
| Group H |
Apr 14 • 03:30 | Caracas FC | | - | | Universidad de Chile | 1 | : | 3 |
| Group E |
Apr 15 • 00:30 | CS Emelec | | - | | SC Internacional | 0 | : | 0 |
| Group A |
Apr 15 • 02:50 | Racing Club de Montevideo | | - | | Corinthians | 0 | : | 2 |
| Group H |
Apr 15 • 02:50 | CD Universidad Católica | | - | | Flamengo | 2 | : | 0 |
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| Group D |
Apr 16 • 00:30 | Club Blooming | | - | | Club Libertad | 1 | : | 2 |
| Group D |
Apr 16 • 00:30 | CA Lanús | | - | | Universitario de Deportes | 0 | : | 0 |
| Group G |
Apr 16 • 02:50 | Colo-Colo | | - | | Cruzeiro EC | 1 | : | 1 |
| Group G |
Apr 16 • 02:50 | Vélez Sársfield | | - | | Deportivo Italia | 4 | : | 0 |
| Group C |
Apr 21 • 02:15 | Club Bolívar | | - | | Juan Aurich | 2 | : | 0 |
| Group C |
Apr 21 • 02:15 | Estudiantes de La Plata | | - | | Alianza Lima | 1 | : | 0 |
| Group F |
Apr 22 • 00:30 | Club Nacional Montevideo | | - | | Monarcas Morelia | 2 | : | 0 |
| Group F |
Apr 22 • 00:30 | CA Banfield | | - | | Deportivo Cuenca | 4 | : | 1 |
| Group B |
Apr 22 • 02:50 | Club Nacional Asunción | | - | | CF Monterrey | 2 | : | 0 |
| Group B |
Apr 22 • 02:50 | São Paulo FC | | - | | Once Caldas | 1 | : | 0 |
| Group H |
Apr 22 • 02:50 | Universidad de Chile | | - | | CD Universidad Católica | 0 | : | 0 |
| Group H |
Apr 22 • 02:50 | Flamengo | | - | | Caracas FC | 3 | : | 2 |
| Group E |
Apr 23 • 00:30 | CA Cerro | | - | | CS Emelec | 0 | : | 0 |
| Group E |
Apr 23 • 00:30 | SC Internacional | | - | | Deportivo Quito | 3 | : | 0 |
| Group A |
Apr 23 • 02:50 | Corinthians | | - | | Independiente Medellín | 1 | : | 0 |
| Group A |
Apr 23 • 02:50 | Cerro Porteño | | - | | Racing Club de Montevideo | 0 | : | 0 |
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| Apr 28 • 01:45 | San Luis FC |  | - | | Estudiantes de La Plata | 0 | : | 1 |
| Apr 28 • 04:00 | Chivas Guadalajara |  | - | | Vélez Sársfield | 3 | : | 0 |
| Apr 29 • 00:30 | Universitario de Deportes | | - | | São Paulo FC | 0 | : | 0 |
| Apr 29 • 02:50 | CA Banfield | | - | | SC Internacional | 3 | : | 1 |
| Apr 29 • 02:50 | Flamengo | | - | | Corinthians | 1 | : | 0 |
| Apr 30 • 00:00 | Cruzeiro EC | | - | | Club Nacional Montevideo | 3 | : | 1 |
| Apr 30 • 02:15 | Alianza Lima | | - | | Universidad de Chile | 0 | : | 1 |
| Apr 30 • 04:30 | Once Caldas | | - | | Club Libertad | 0 | : | 0 |
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| May 05 • 00:30 | São Paulo FC | | - | | Universitario de Deportes | 3 | : | 1 |
| May 05 • 02:50 | Vélez Sársfield | | - | | Chivas Guadalajara | 2 | : | 0 |
| May 06 • 00:30 | Estudiantes de La Plata | | - | | San Luis FC | 3 | : | 1 |
| May 06 • 02:50 | Club Nacional Montevideo | | - | | Cruzeiro EC | 0 | : | 3 |
| May 06 • 02:50 | Corinthians | | - | | Flamengo | 2 | : | 1 |
| May 07 • 00:30 | SC Internacional | | - | | CA Banfield | 2 | : | 0 |
| May 07 • 03:00 | Universidad de Chile | | - | | Alianza Lima | 2 | : | 2 |
| May 07 • 03:00 | Club Libertad | | - | | Once Caldas | 2 | : | 1 |
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| May 12 • 03:15 | Chivas Guadalajara | | - | | Club Libertad | 3 | : | 0 |
| May 13 • 00:30 | Flamengo | | - | | Universidad de Chile | 2 | : | 3 |
| May 13 • 02:50 | Cruzeiro EC | | - | | São Paulo FC | 0 | : | 2 |
| May 14 • 02:15 | SC Internacional | | - | | Estudiantes de La Plata | 1 | : | 0 |
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| May 19 • 03:15 | Club Libertad | | - | | Chivas Guadalajara | 2 | : | 0 |
| May 20 • 02:50 | São Paulo FC | | - | | Cruzeiro EC | 2 | : | 0 |
| May 21 • 00:45 | Estudiantes de La Plata | | - | | SC Internacional | 2 | : | 1 |
| May 21 • 03:15 | Universidad de Chile | | - | | Flamengo | 1 | : | 2 |
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| Jul 28 • 04:15 | Chivas Guadalajara | | - | | Universidad de Chile | 1 | : | 1 |
| Jul 29 • 02:50 | SC Internacional | | - | | São Paulo FC | 1 | : | 0 |
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| Aug 04 • 03:15 | Universidad de Chile | | - | | Chivas Guadalajara | 0 | : | 2 |
| Aug 06 • 02:50 | São Paulo FC | | - | | SC Internacional | 2 | : | 1 |
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| Aug 12 • 02:50 | Chivas Guadalajara | | - | | SC Internacional | 1 | : | 2 |
| Aug 19 • 02:50 | SC Internacional | | - | | Chivas Guadalajara | 3 | : | 2 |
