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| Pool A |
Oct 12 • 20:45 | Leinster Rugby |  | - |  | Wasps RFC | 52 | : | 3 |
| Pool A |
Oct 13 • 14:00 | Bath Rugby |  | - |  | Stade Toulousain | 20 | : | 22 |
| Pool B |
Oct 13 • 16:15 | Exeter Chiefs |  | - |  | Munster Rugby | 10 | : | 10 |
| Pool E |
Oct 13 • 16:15 | Montpellier Hérault Rugby |  | - |  | Edinburgh Rugby | 21 | : | 15 |
| Pool D |
Oct 13 • 18:30 | Scarlets |  | - |  | Racing 92 | 13 | : | 14 |
| Pool D |
Oct 13 • 18:30 | Ulster Rugby |  | - |  | Leicester Tigers | 24 | : | 10 |
| Pool B |
Oct 14 • 14:00 | Gloucester Rugby |  | - |  | Castres Olympique | 19 | : | 14 |
| Pool C |
Oct 14 • 14:00 | Lyon OU |  | - |  | Cardiff Rugby | 21 | : | 30 |
| Pool C |
Oct 14 • 16:15 | Glasgow Warriors |  | - |  | Saracens | 3 | : | 13 |
| Pool E |
Oct 14 • 16:15 | RC Toulonnais |  | - |  | Newcastle Falcons | 25 | : | 26 |
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| Pool D |
Oct 19 • 20:45 | Leicester Tigers | | - | | Scarlets | 45 | : | 27 |
| Pool B |
Oct 20 • 14:00 | Munster Rugby | | - | | Gloucester Rugby | 36 | : | 22 |
| Pool B |
Oct 20 • 14:00 | Castres Olympique | | - | | Exeter Chiefs | 29 | : | 25 |
| Pool A |
Oct 20 • 16:15 | Wasps RFC | | - | | Bath Rugby | 35 | : | 35 |
| Pool E |
Oct 20 • 16:15 | Edinburgh Rugby | | - | | RC Toulonnais | 40 | : | 14 |
| Pool C |
Oct 20 • 18:30 | Saracens | | - | | Lyon OU | 29 | : | 10 |
| Pool D |
Oct 20 • 18:30 | Racing 92 | | - | | Ulster Rugby | 44 | : | 12 |
| Pool E |
Oct 21 • 14:00 | Newcastle Falcons | | - | | Montpellier Hérault Rugby | 23 | : | 20 |
| Pool A |
Oct 21 • 16:15 | Stade Toulousain | | - | | Leinster Rugby | 28 | : | 27 |
| Pool C |
Oct 21 • 16:15 | Cardiff Rugby | | - | | Glasgow Warriors | 12 | : | 29 |
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| Pool D |
Dec 07 • 20:45 | Scarlets | | - | | Ulster Rugby | 24 | : | 25 |
| Pool E |
Dec 07 • 20:45 | Edinburgh Rugby | | - | | Newcastle Falcons | 31 | : | 13 |
| Pool B |
Dec 08 • 14:00 | Exeter Chiefs | | - | | Gloucester Rugby | 19 | : | 27 |
| Pool C |
Dec 08 • 14:00 | Lyon OU | | - | | Glasgow Warriors | 22 | : | 42 |
| Pool A |
Dec 08 • 16:15 | Bath Rugby | | - | | Leinster Rugby | 10 | : | 17 |
| Pool E |
Dec 08 • 16:15 | RC Toulonnais | | - | | Montpellier Hérault Rugby | 38 | : | 28 |
| Pool A |
Dec 08 • 18:30 | Wasps RFC | | - | | Stade Toulousain | 16 | : | 24 |
| Pool B |
Dec 09 • 14:00 | Munster Rugby | | - | | Castres Olympique | 30 | : | 5 |
| Pool C |
Dec 09 • 14:00 | Saracens | | - | | Cardiff Rugby | 51 | : | 25 |
| Pool D |
Dec 09 • 16:15 | Racing 92 | | - | | Leicester Tigers | 36 | : | 26 |
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| Pool B |
Dec 14 • 20:45 | Gloucester Rugby | | - | | Exeter Chiefs | 17 | : | 29 |
| Pool D |
Dec 14 • 20:45 | Ulster Rugby | | - | | Scarlets | 30 | : | 15 |
| Pool C |
Dec 15 • 14:00 | Glasgow Warriors | | - | | Lyon OU | 21 | : | 10 |
| Pool C |
Dec 15 • 14:00 | Cardiff Rugby | | - | | Saracens | 14 | : | 26 |
| Pool A |
Dec 15 • 16:15 | Stade Toulousain | | - | | Wasps RFC | 42 | : | 27 |
| Pool A |
Dec 15 • 18:30 | Leinster Rugby | | - | | Bath Rugby | 42 | : | 15 |
| Pool B |
Dec 15 • 18:30 | Castres Olympique | | - | | Munster Rugby | 13 | : | 12 |
| Pool D |
Dec 16 • 14:00 | Leicester Tigers | | - | | Racing 92 | 11 | : | 34 |
| Pool E |
Dec 16 • 16:15 | Newcastle Falcons | | - | | Edinburgh Rugby | 8 | : | 21 |
| Pool E |
Dec 16 • 16:15 | Montpellier Hérault Rugby | | - | | RC Toulonnais | 34 | : | 13 |
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| Pool B |
Jan 11 • 20:45 | Gloucester Rugby | | - | | Munster Rugby | 15 | : | 41 |
| Pool A |
Jan 12 • 14:00 | Leinster Rugby | | - | | Stade Toulousain | 29 | : | 13 |
| Pool E |
Jan 12 • 14:00 | Montpellier Hérault Rugby | | - | | Newcastle Falcons | 45 | : | 8 |
| Pool A |
Jan 12 • 16:15 | Bath Rugby | | - | | Wasps RFC | 18 | : | 16 |
| Pool D |
Jan 12 • 16:15 | Ulster Rugby | | - | | Racing 92 | 26 | : | 22 |
| Pool D |
Jan 12 • 18:30 | Scarlets | | - | | Leicester Tigers | 33 | : | 10 |
| Pool E |
Jan 12 • 18:30 | RC Toulonnais | | - | | Edinburgh Rugby | 17 | : | 28 |
| Pool B |
Jan 13 • 14:00 | Exeter Chiefs | | - | | Castres Olympique | 34 | : | 12 |
| Pool C |
Jan 13 • 16:15 | Glasgow Warriors | | - | | Cardiff Rugby | 33 | : | 24 |
| Pool C |
Jan 13 • 16:15 | Lyon OU | | - | | Saracens | 10 | : | 28 |
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| Pool E |
Jan 18 • 20:45 | Newcastle Falcons | | - | | RC Toulonnais | 24 | : | 27 |
| Pool E |
Jan 18 • 20:45 | Edinburgh Rugby | | - | | Montpellier Hérault Rugby | 19 | : | 10 |
| Pool C |
Jan 19 • 14:00 | Saracens | | - | | Glasgow Warriors | 38 | : | 19 |
| Pool C |
Jan 19 • 14:00 | Cardiff Rugby | | - | | Lyon OU | 33 | : | 14 |
| Pool D |
Jan 19 • 16:15 | Leicester Tigers | | - | | Ulster Rugby | 13 | : | 14 |
| Pool D |
Jan 19 • 16:15 | Racing 92 | | - | | Scarlets | 46 | : | 33 |
| Pool B |
Jan 19 • 18:30 | Munster Rugby | | - | | Exeter Chiefs | 9 | : | 7 |
| Pool B |
Jan 19 • 18:30 | Castres Olympique | | - | | Gloucester Rugby | 26 | : | 22 |
| Pool A |
Jan 20 • 16:15 | Wasps RFC | | - | | Leinster Rugby | 19 | : | 37 |
| Pool A |
Jan 20 • 16:15 | Stade Toulousain | | - | | Bath Rugby | 20 | : | 17 |
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| Mar 30 • 13:45 | Edinburgh Rugby | | - | | Munster Rugby | 13 | : | 17 |
| Mar 30 • 16:15 | Saracens | | - | | Glasgow Warriors | 56 | : | 27 |
| Mar 30 • 18:45 | Leinster Rugby | | - | | Ulster Rugby | 21 | : | 18 |
| Mar 31 • 16:15 | Racing 92 | | - | | Stade Toulousain | 21 | : | 22 |
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| Apr 20 • 16:00 | Saracens | | - | | Munster Rugby | 32 | : | 16 |
| Apr 21 • 16:15 | Leinster Rugby | | - | | Stade Toulousain | 30 | : | 12 |
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| May 11 • 18:00 | Saracens | | - | | Leinster Rugby | 20 | : | 10 |
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