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| Feb 20 • 00:30 | FBC Melgar |  | - |  | Caracas FC | 2 | : | 0 |
| Feb 20 • 22:15 | Talleres de Córdoba |  | - |  | CD Palestino | 2 | : | 2 |
| Feb 21 • 00:30 | Defensor Sporting |  | - |  | Atlético Mineiro | 0 | : | 2 |
| Feb 22 • 01:30 | Club Libertad |  | - |  | Atlético Nacional | 1 | : | 0 |
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| Feb 27 • 01:30 | Caracas FC | | - | | FBC Melgar | 2 | : | 1 |
| Feb 27 • 23:15 | CD Palestino | | - | | Talleres de Córdoba | 2 | : | 1 |
| Feb 28 • 01:30 | Atlético Mineiro | | - | | Defensor Sporting | 0 | : | 0 |
| Mar 01 • 01:30 | Atlético Nacional | | - | | Club Libertad | 1 | : | 0 |
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| Group C |
Mar 05 • 23:15 | Godoy Cruz |  | - |  | Olimpia Asunción | 0 | : | 0 |
| Group D |
Mar 05 • 23:15 | Club San José |  | - |  | Flamengo | 0 | : | 1 |
| Group F |
Mar 05 • 23:15 | FBC Melgar | | - |  | San Lorenzo | 0 | : | 0 |
| Group G |
Mar 06 • 01:30 | Club Jorge Wilstermann |  | - |  | Boca Juniors | 0 | : | 0 |
| Group G |
Mar 06 • 01:30 | Deportes Tolima |  | - |  | Club Athletico Paranaense | 1 | : | 0 |
| Group H |
Mar 06 • 01:30 | Club Libertad | | - |  | CD Universidad Católica | 4 | : | 1 |
| Group A |
Mar 06 • 23:15 | CD Palestino | | - |  | SC Internacional | 0 | : | 1 |
| Group C |
Mar 06 • 23:15 | Universidad de Concepción |  | - |  | Sporting Cristal | 5 | : | 4 |
| Group E |
Mar 06 • 23:15 | Atlético Mineiro | | - |  | Cerro Porteño | 0 | : | 1 |
| Group A |
Mar 07 • 01:30 | Alianza Lima |  | - |  | River Plate | 1 | : | 1 |
| Group E |
Mar 07 • 01:30 | Zamora FC |  | - |  | Club Nacional Montevideo | 0 | : | 1 |
| Group F |
Mar 07 • 01:30 | Atlético Junior |  | - |  | SE Palmeiras | 0 | : | 2 |
| Group H |
Mar 07 • 01:30 | Rosario Central |  | - |  | Grêmio Porto Alegrense | 1 | : | 1 |
| Group B |
Mar 07 • 23:00 | CA Huracán |  | - |  | Cruzeiro EC | 0 | : | 1 |
| Group D |
Mar 08 • 01:00 | LDU Quito |  | - |  | CA Peñarol | 2 | : | 0 |
| Group B |
Mar 08 • 20:00 | Deportivo Lara |  | - |  | CS Emelec | 0 | : | 0 |
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| Group C |
Mar 12 • 23:15 | Olimpia Asunción | | - | | Universidad de Concepción | 1 | : | 1 |
| Group F |
Mar 12 • 23:15 | SE Palmeiras | | - | | FBC Melgar | 3 | : | 0 |
| Group G |
Mar 12 • 23:15 | Boca Juniors | | - | | Deportes Tolima | 3 | : | 0 |
| Group C |
Mar 13 • 01:30 | Sporting Cristal | | - | | Godoy Cruz | 1 | : | 1 |
| Group E |
Mar 13 • 01:30 | Club Nacional Montevideo | | - | | Atlético Mineiro | 1 | : | 0 |
| Group H |
Mar 13 • 01:30 | Grêmio Porto Alegrense | | - | | Club Libertad | 0 | : | 1 |
| Group E |
Mar 13 • 23:15 | Cerro Porteño | | - | | Zamora FC | 2 | : | 1 |
| Group F |
Mar 13 • 23:15 | San Lorenzo | | - | | Atlético Junior | 1 | : | 0 |
| Group A |
Mar 14 • 01:30 | SC Internacional | | - | | Alianza Lima | 2 | : | 0 |
| Group A |
Mar 14 • 01:30 | River Plate | | - | | CD Palestino | 0 | : | 0 |
| Group D |
Mar 14 • 01:30 | Flamengo | | - | | LDU Quito | 3 | : | 1 |
| Group H |
Mar 14 • 01:30 | CD Universidad Católica | | - | | Rosario Central | 2 | : | 1 |
| Group D |
Mar 14 • 23:00 | CA Peñarol | | - | | Club San José | 4 | : | 0 |
| Group G |
Mar 15 • 01:00 | Club Athletico Paranaense | | - | | Club Jorge Wilstermann | 4 | : | 0 |
| Group B |
Mar 15 • 03:00 | CS Emelec | | - | | CA Huracán | 0 | : | 0 |
| Group B |
Mar 28 • 01:30 | Cruzeiro EC | | - | | Deportivo Lara | 2 | : | 0 |
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| Group D |
Apr 03 • 00:15 | Club San José | | - | | LDU Quito | 3 | : | 3 |
| Group E |
Apr 03 • 00:15 | Cerro Porteño | | - | | Club Nacional Montevideo | 1 | : | 0 |
| Group F |
Apr 03 • 00:15 | San Lorenzo | | - | | SE Palmeiras | 1 | : | 0 |
| Group A |
Apr 03 • 02:30 | CD Palestino | | - | | Alianza Lima | 3 | : | 0 |
| Group F |
Apr 03 • 02:30 | FBC Melgar | | - | | Atlético Junior | 1 | : | 0 |
| Group G |
Apr 03 • 02:30 | Club Athletico Paranaense | | - | | Boca Juniors | 3 | : | 0 |
| Group A |
Apr 04 • 00:15 | SC Internacional | | - | | River Plate | 2 | : | 2 |
| Group C |
Apr 04 • 00:15 | Universidad de Concepción | | - | | Godoy Cruz | 0 | : | 0 |
| Group E |
Apr 04 • 00:15 | Atlético Mineiro | | - | | Zamora FC | 3 | : | 2 |
| Group B |
Apr 04 • 02:30 | CS Emelec | | - | | Cruzeiro EC | 0 | : | 1 |
| Group B |
Apr 04 • 02:30 | Deportivo Lara | | - | | CA Huracán | 2 | : | 1 |
| Group D |
Apr 04 • 02:30 | Flamengo | | - | | CA Peñarol | 0 | : | 1 |
| Group G |
Apr 04 • 02:30 | Deportes Tolima | | - | | Club Jorge Wilstermann | 2 | : | 2 |
| Group H |
Apr 05 • 00:00 | CD Universidad Católica | | - | | Grêmio Porto Alegrense | 1 | : | 0 |
| Group H |
Apr 05 • 02:00 | Club Libertad | | - | | Rosario Central | 2 | : | 0 |
| Group C |
Apr 05 • 04:00 | Sporting Cristal | | - | | Olimpia Asunción | 0 | : | 3 |
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| Group C |
Apr 10 • 00:15 | Olimpia Asunción | | - | | Godoy Cruz | 2 | : | 1 |
| Group G |
Apr 10 • 00:15 | Club Athletico Paranaense | | - | | Deportes Tolima | 1 | : | 0 |
| Group A |
Apr 10 • 02:30 | SC Internacional | | - | | CD Palestino | 3 | : | 2 |
| Group D |
Apr 10 • 02:30 | CA Peñarol | | - | | LDU Quito | 1 | : | 0 |
| Group F |
Apr 10 • 02:30 | San Lorenzo | | - | | FBC Melgar | 2 | : | 0 |
| Group B |
Apr 11 • 00:15 | Cruzeiro EC | | - | | CA Huracán | 4 | : | 0 |
| Group C |
Apr 11 • 00:15 | Sporting Cristal | | - | | Universidad de Concepción | 2 | : | 0 |
| Group E |
Apr 11 • 00:15 | Club Nacional Montevideo | | - | | Zamora FC | 1 | : | 0 |
| Group E |
Apr 11 • 00:15 | Cerro Porteño | | - | | Atlético Mineiro | 4 | : | 1 |
| Group F |
Apr 11 • 02:30 | SE Palmeiras | | - | | Atlético Junior | 3 | : | 0 |
| Group G |
Apr 11 • 02:30 | Boca Juniors | | - | | Club Jorge Wilstermann | 4 | : | 0 |
| Group H |
Apr 11 • 02:30 | Grêmio Porto Alegrense | | - | | Rosario Central | 3 | : | 1 |
| Group H |
Apr 11 • 02:30 | CD Universidad Católica | | - | | Club Libertad | 2 | : | 3 |
| Group A |
Apr 12 • 00:00 | River Plate | | - | | Alianza Lima | 3 | : | 0 |
| Group D |
Apr 12 • 02:00 | Flamengo | | - | | Club San José | 6 | : | 1 |
| Group B |
Apr 12 • 04:00 | CS Emelec | | - | | Deportivo Lara | 2 | : | 2 |
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| Group B |
Apr 23 • 22:00 | Deportivo Lara | | - | | Cruzeiro EC | 0 | : | 2 |
| Group B |
Apr 24 • 00:15 | CA Huracán | | - | | CS Emelec | 1 | : | 2 |
| Group C |
Apr 24 • 00:15 | Universidad de Concepción | | - | | Olimpia Asunción | 3 | : | 3 |
| Group H |
Apr 24 • 00:15 | Club Libertad | | - | | Grêmio Porto Alegrense | 0 | : | 2 |
| Group C |
Apr 24 • 02:30 | Godoy Cruz | | - | | Sporting Cristal | 2 | : | 0 |
| Group E |
Apr 24 • 02:30 | Atlético Mineiro | | - | | Club Nacional Montevideo | 0 | : | 1 |
| Group A |
Apr 25 • 00:15 | CD Palestino | | - | | River Plate | 0 | : | 2 |
| Group G |
Apr 25 • 00:15 | Club Jorge Wilstermann | | - | | Club Athletico Paranaense | 3 | : | 2 |
| Group H |
Apr 25 • 00:15 | Rosario Central | | - | | CD Universidad Católica | 1 | : | 1 |
| Group A |
Apr 25 • 02:30 | Alianza Lima | | - | | SC Internacional | 0 | : | 1 |
| Group D |
Apr 25 • 02:30 | Club San José | | - | | CA Peñarol | 3 | : | 1 |
| Group D |
Apr 25 • 02:30 | LDU Quito | | - | | Flamengo | 2 | : | 1 |
| Group G |
Apr 25 • 02:30 | Deportes Tolima | | - | | Boca Juniors | 2 | : | 2 |
| Group E |
Apr 25 • 22:00 | Zamora FC | | - | | Cerro Porteño | 2 | : | 1 |
| Group F |
Apr 26 • 02:00 | Atlético Junior | | - | | San Lorenzo | 1 | : | 0 |
| Group F |
Apr 26 • 04:00 | FBC Melgar | | - | | SE Palmeiras | 0 | : | 4 |
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| Group E |
May 08 • 00:15 | Club Nacional Montevideo | | - | | Cerro Porteño | 1 | : | 1 |
| Group E |
May 08 • 00:15 | Zamora FC | | - | | Atlético Mineiro | 1 | : | 2 |
| Group A |
May 08 • 02:30 | River Plate | | - | | SC Internacional | 2 | : | 2 |
| Group A |
May 08 • 02:30 | Alianza Lima | | - | | CD Palestino | 1 | : | 2 |
| Group B |
May 09 • 00:15 | Cruzeiro EC | | - | | CS Emelec | 1 | : | 2 |
| Group B |
May 09 • 00:15 | CA Huracán | | - | | Deportivo Lara | 3 | : | 0 |
| Group H |
May 09 • 00:15 | Grêmio Porto Alegrense | | - | | CD Universidad Católica | 2 | : | 0 |
| Group H |
May 09 • 00:15 | Rosario Central | | - | | Club Libertad | 2 | : | 1 |
| Group D |
May 09 • 02:30 | CA Peñarol | | - | | Flamengo | 0 | : | 0 |
| Group D |
May 09 • 02:30 | LDU Quito | | - | | Club San José | 4 | : | 0 |
| Group F |
May 09 • 02:30 | SE Palmeiras | | - | | San Lorenzo | 1 | : | 0 |
| Group F |
May 09 • 02:30 | Atlético Junior | | - | | FBC Melgar | 0 | : | 1 |
| Group C |
May 10 • 00:15 | Olimpia Asunción | | - | | Sporting Cristal | 0 | : | 1 |
| Group C |
May 10 • 00:15 | Godoy Cruz | | - | | Universidad de Concepción | 1 | : | 0 |
| Group G |
May 10 • 02:30 | Boca Juniors | | - | | Club Athletico Paranaense | 2 | : | 1 |
| Group G |
May 10 • 02:30 | Club Jorge Wilstermann | | - | | Deportes Tolima | 0 | : | 2 |
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| Jul 24 • 00:15 | River Plate | | - | | Cruzeiro EC | 0 | : | 0 |
| Jul 24 • 02:30 | Godoy Cruz | | - | | SE Palmeiras | 2 | : | 2 |
| Jul 24 • 02:30 | LDU Quito | | - | | Olimpia Asunción | 3 | : | 1 |
| Jul 25 • 00:15 | Club Nacional Montevideo | | - | | SC Internacional | 0 | : | 1 |
| Jul 25 • 00:15 | San Lorenzo | | - | | Cerro Porteño | 0 | : | 0 |
| Jul 25 • 02:30 | Club Athletico Paranaense | | - | | Boca Juniors | 0 | : | 1 |
| Jul 25 • 02:30 | CS Emelec | | - | | Flamengo | 2 | : | 0 |
| Jul 26 • 02:30 | Grêmio Porto Alegrense | | - | | Club Libertad | 2 | : | 0 |
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| Jul 31 • 00:15 | Cruzeiro EC | | - | | River Plate | 0 | : | 0 |
| Jul 31 • 02:30 | Olimpia Asunción | | - | | LDU Quito | 1 | : | 1 |
| Jul 31 • 02:30 | SE Palmeiras | | - | | Godoy Cruz | 4 | : | 0 |
| Aug 01 • 00:15 | Cerro Porteño | | - | | San Lorenzo | 2 | : | 1 |
| Aug 01 • 00:15 | SC Internacional | | - | | Club Nacional Montevideo | 2 | : | 0 |
| Aug 01 • 02:30 | Boca Juniors | | - | | Club Athletico Paranaense | 2 | : | 0 |
| Aug 01 • 02:30 | Flamengo | | - | | CS Emelec | 2 | : | 0 |
| Aug 02 • 02:30 | Club Libertad | | - | | Grêmio Porto Alegrense | 0 | : | 3 |
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| Aug 21 • 02:30 | Grêmio Porto Alegrense | | - | | SE Palmeiras | 0 | : | 1 |
| Aug 22 • 00:15 | LDU Quito | | - | | Boca Juniors | 0 | : | 3 |
| Aug 22 • 02:30 | Flamengo | | - | | SC Internacional | 2 | : | 0 |
| Aug 23 • 00:15 | River Plate | | - | | Cerro Porteño | 2 | : | 0 |
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| Aug 28 • 02:30 | SE Palmeiras | | - | | Grêmio Porto Alegrense | 1 | : | 2 |
| Aug 29 • 00:15 | Boca Juniors | | - | | LDU Quito | 0 | : | 0 |
| Aug 29 • 02:30 | SC Internacional | | - | | Flamengo | 1 | : | 1 |
| Aug 30 • 00:15 | Cerro Porteño | | - | | River Plate | 1 | : | 1 |
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| Oct 02 • 02:30 | River Plate | | - | | Boca Juniors | 2 | : | 0 |
| Oct 03 • 02:30 | Grêmio Porto Alegrense | | - | | Flamengo | 1 | : | 1 |
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| Oct 23 • 02:30 | Boca Juniors | | - | | River Plate | 1 | : | 0 |
| Oct 24 • 02:30 | Flamengo | | - | | Grêmio Porto Alegrense | 5 | : | 0 |
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| Nov 23 • 21:00 | River Plate | | - | | Flamengo | 1 | : | 2 |
