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| Mar 09 • 01:30 | América FC |  | - |  | Barcelona SC | 0 | : | 0 |
| Mar 09 • 23:15 | Everton Viña del Mar |  | - |  | Estudiantes de La Plata | 0 | : | 1 |
| Mar 10 • 01:30 | Fluminense FC |  | - |  | Olimpia Asunción | 3 | : | 1 |
| Mar 11 • 01:30 | Universidad Católica de Ecuador |  | - |  | The Strongest | 0 | : | 0 |
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| Mar 16 • 01:30 | Barcelona SC | | - | | América FC | 0 | : | 0 |
| Mar 16 • 23:15 | Estudiantes de La Plata | | - | | Everton Viña del Mar | 1 | : | 0 |
| Mar 17 • 01:30 | Olimpia Asunción | | - | | Fluminense FC | 2 | : | 0 |
| Mar 18 • 01:30 | The Strongest | | - | | Universidad Católica de Ecuador | 2 | : | 1 |
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| Group B |
Apr 06 • 00:15 | Caracas FC |  | - |  | Club Athletico Paranaense | 0 | : | 0 |
| Group G |
Apr 06 • 00:15 | Olimpia Asunción | | - |  | Cerro Porteño | 0 | : | 0 |
| Group G |
Apr 06 • 00:15 | Colón de Santa Fe |  | - |  | CA Peñarol | 2 | : | 1 |
| Group E |
Apr 06 • 02:30 | Club Always Ready |  | - |  | Corinthians | 2 | : | 0 |
| Group E |
Apr 06 • 02:30 | Deportivo Cali |  | - |  | Boca Juniors | 2 | : | 0 |
| Group H |
Apr 06 • 03:00 | Sporting Cristal |  | - |  | Flamengo | 0 | : | 2 |
| Group C |
Apr 07 • 00:00 | RB Bragantino |  | - |  | Club Nacional Montevideo | 2 | : | 0 |
| Group D |
Apr 07 • 00:00 | América FC | | - |  | Independiente del Valle | 0 | : | 2 |
| Group H |
Apr 07 • 00:00 | Talleres de Córdoba |  | - |  | CD Universidad Católica | 1 | : | 0 |
| Group A |
Apr 07 • 02:00 | Deportivo Táchira |  | - |  | SE Palmeiras | 0 | : | 4 |
| Group D |
Apr 07 • 02:00 | Deportes Tolima |  | - |  | Atlético Mineiro | 0 | : | 2 |
| Group F |
Apr 07 • 02:00 | Alianza Lima |  | - |  | River Plate | 0 | : | 1 |
| Group A |
Apr 07 • 04:00 | Independiente Petrolero |  | - |  | CS Emelec | 1 | : | 1 |
| Group F |
Apr 08 • 00:00 | Fortaleza EC |  | - |  | Colo-Colo | 1 | : | 2 |
| Group C |
Apr 08 • 02:00 | Estudiantes de La Plata | | - |  | Vélez Sársfield | 4 | : | 1 |
| Group B |
Apr 08 • 04:00 | The Strongest | | - |  | Club Libertad | 1 | : | 1 |
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| Group E |
Apr 13 • 00:15 | Boca Juniors | | - | | Club Always Ready | 2 | : | 0 |
| Group G |
Apr 13 • 00:15 | Cerro Porteño | | - | | Colón de Santa Fe | 3 | : | 1 |
| Group H |
Apr 13 • 00:15 | CD Universidad Católica | | - | | Sporting Cristal | 2 | : | 1 |
| Group A |
Apr 13 • 02:30 | SE Palmeiras | | - | | Independiente Petrolero | 8 | : | 1 |
| Group G |
Apr 13 • 02:30 | CA Peñarol | | - | | Olimpia Asunción | 2 | : | 1 |
| Group H |
Apr 13 • 02:30 | Flamengo | | - | | Talleres de Córdoba | 3 | : | 1 |
| Group B |
Apr 14 • 00:00 | Club Libertad | | - | | Caracas FC | 2 | : | 1 |
| Group F |
Apr 14 • 00:00 | Colo-Colo | | - | | Alianza Lima | 2 | : | 1 |
| Group C |
Apr 14 • 02:00 | Club Nacional Montevideo | | - | | Estudiantes de La Plata | 0 | : | 0 |
| Group D |
Apr 14 • 02:00 | Atlético Mineiro | | - | | América FC | 1 | : | 1 |
| Group E |
Apr 14 • 02:00 | Corinthians | | - | | Deportivo Cali | 1 | : | 0 |
| Group F |
Apr 14 • 02:00 | River Plate | | - | | Fortaleza EC | 2 | : | 0 |
| Group D |
Apr 14 • 04:00 | Independiente del Valle | | - | | Deportes Tolima | 2 | : | 2 |
| Group B |
Apr 15 • 00:00 | Club Athletico Paranaense | | - | | The Strongest | 1 | : | 0 |
| Group C |
Apr 15 • 02:00 | Vélez Sársfield | | - | | RB Bragantino | 2 | : | 2 |
| Group A |
Apr 15 • 04:00 | CS Emelec | | - | | Deportivo Táchira | 1 | : | 1 |
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| Group A |
Apr 27 • 00:15 | Independiente Petrolero | | - | | Deportivo Táchira | 1 | : | 2 |
| Group B |
Apr 27 • 00:15 | Club Libertad | | - | | Club Athletico Paranaense | 1 | : | 0 |
| Group C |
Apr 27 • 00:15 | Vélez Sársfield | | - | | Club Nacional Montevideo | 1 | : | 2 |
| Group C |
Apr 27 • 00:15 | Estudiantes de La Plata | | - | | RB Bragantino | 2 | : | 0 |
| Group D |
Apr 27 • 02:30 | Independiente del Valle | | - | | Atlético Mineiro | 1 | : | 1 |
| Group E |
Apr 27 • 02:30 | Corinthians | | - | | Boca Juniors | 2 | : | 0 |
| Group H |
Apr 27 • 02:30 | Talleres de Córdoba | | - | | Sporting Cristal | 1 | : | 0 |
| Group D |
Apr 28 • 00:00 | América FC | | - | | Deportes Tolima | 2 | : | 3 |
| Group F |
Apr 28 • 00:00 | Fortaleza EC | | - | | Alianza Lima | 2 | : | 1 |
| Group A |
Apr 28 • 02:00 | CS Emelec | | - | | SE Palmeiras | 1 | : | 3 |
| Group F |
Apr 28 • 02:00 | Colo-Colo | | - | | River Plate | 1 | : | 2 |
| Group G |
Apr 28 • 02:00 | Cerro Porteño | | - | | CA Peñarol | 1 | : | 0 |
| Group B |
Apr 28 • 04:00 | The Strongest | | - | | Caracas FC | 1 | : | 1 |
| Group H |
Apr 29 • 00:00 | CD Universidad Católica | | - | | Flamengo | 2 | : | 3 |
| Group G |
Apr 29 • 02:00 | Olimpia Asunción | | - | | Colón de Santa Fe | 0 | : | 0 |
| Group E |
Apr 29 • 04:00 | Club Always Ready | | - | | Deportivo Cali | 2 | : | 2 |
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| Group A |
May 04 • 00:15 | Deportivo Táchira | | - | | CS Emelec | 1 | : | 4 |
| Group B |
May 04 • 00:15 | Caracas FC | | - | | Club Libertad | 1 | : | 0 |
| Group B |
May 04 • 00:15 | The Strongest | | - | | Club Athletico Paranaense | 5 | : | 0 |
| Group A |
May 04 • 02:30 | Independiente Petrolero | | - | | SE Palmeiras | 0 | : | 5 |
| Group C |
May 04 • 02:30 | Estudiantes de La Plata | | - | | Club Nacional Montevideo | 1 | : | 0 |
| Group D |
May 04 • 02:30 | América FC | | - | | Atlético Mineiro | 1 | : | 2 |
| Group G |
May 05 • 00:00 | Colón de Santa Fe | | - | | Cerro Porteño | 2 | : | 1 |
| Group H |
May 05 • 00:00 | Talleres de Córdoba | | - | | Flamengo | 2 | : | 2 |
| Group E |
May 05 • 02:00 | Deportivo Cali | | - | | Corinthians | 0 | : | 0 |
| Group E |
May 05 • 02:00 | Club Always Ready | | - | | Boca Juniors | 0 | : | 1 |
| Group G |
May 05 • 02:00 | Olimpia Asunción | | - | | CA Peñarol | 1 | : | 0 |
| Group D |
May 05 • 04:00 | Deportes Tolima | | - | | Independiente del Valle | 1 | : | 0 |
| Group H |
May 05 • 04:00 | Sporting Cristal | | - | | CD Universidad Católica | 1 | : | 1 |
| Group F |
May 06 • 00:00 | Fortaleza EC | | - | | River Plate | 1 | : | 1 |
| Group C |
May 06 • 02:00 | RB Bragantino | | - | | Vélez Sársfield | 1 | : | 1 |
| Group F |
May 06 • 04:00 | Alianza Lima | | - | | Colo-Colo | 1 | : | 1 |
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| Group B |
May 18 • 00:15 | Caracas FC | | - | | The Strongest | 0 | : | 0 |
| Group C |
May 18 • 00:15 | RB Bragantino | | - | | Estudiantes de La Plata | 0 | : | 1 |
| Group G |
May 18 • 00:15 | CA Peñarol | | - | | Cerro Porteño | 0 | : | 0 |
| Group E |
May 18 • 02:30 | Boca Juniors | | - | | Corinthians | 1 | : | 1 |
| Group H |
May 18 • 02:30 | Flamengo | | - | | CD Universidad Católica | 3 | : | 0 |
| Group H |
May 18 • 02:30 | Sporting Cristal | | - | | Talleres de Córdoba | 0 | : | 0 |
| Group A |
May 19 • 00:00 | SE Palmeiras | | - | | CS Emelec | 1 | : | 0 |
| Group B |
May 19 • 00:00 | Club Athletico Paranaense | | - | | Club Libertad | 2 | : | 0 |
| Group C |
May 19 • 00:00 | Club Nacional Montevideo | | - | | Vélez Sársfield | 2 | : | 3 |
| Group A |
May 19 • 02:00 | Deportivo Táchira | | - | | Independiente Petrolero | 3 | : | 0 |
| Group D |
May 19 • 02:00 | Deportes Tolima | | - | | América FC | 2 | : | 2 |
| Group G |
May 19 • 02:00 | Colón de Santa Fe | | - | | Olimpia Asunción | 2 | : | 1 |
| Group F |
May 19 • 04:00 | Alianza Lima | | - | | Fortaleza EC | 0 | : | 2 |
| Group D |
May 20 • 00:00 | Atlético Mineiro | | - | | Independiente del Valle | 3 | : | 1 |
| Group F |
May 20 • 02:00 | River Plate | | - | | Colo-Colo | 4 | : | 0 |
| Group E |
May 20 • 04:00 | Deportivo Cali | | - | | Club Always Ready | 3 | : | 0 |
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| Group C |
May 25 • 00:15 | Club Nacional Montevideo | | - | | RB Bragantino | 3 | : | 0 |
| Group C |
May 25 • 00:15 | Vélez Sársfield | | - | | Estudiantes de La Plata | 4 | : | 0 |
| Group A |
May 25 • 02:30 | SE Palmeiras | | - | | Deportivo Táchira | 4 | : | 1 |
| Group A |
May 25 • 02:30 | CS Emelec | | - | | Independiente Petrolero | 7 | : | 0 |
| Group H |
May 25 • 02:30 | Flamengo | | - | | Sporting Cristal | 2 | : | 1 |
| Group H |
May 25 • 02:30 | CD Universidad Católica | | - | | Talleres de Córdoba | 0 | : | 1 |
| Group F |
May 26 • 00:00 | River Plate | | - | | Alianza Lima | 8 | : | 1 |
| Group F |
May 26 • 00:00 | Colo-Colo | | - | | Fortaleza EC | 3 | : | 4 |
| Group D |
May 26 • 02:00 | Atlético Mineiro | | - | | Deportes Tolima | 1 | : | 2 |
| Group D |
May 26 • 02:00 | Independiente del Valle | | - | | América FC | 3 | : | 0 |
| Group G |
May 26 • 02:00 | CA Peñarol | | - | | Colón de Santa Fe | 2 | : | 1 |
| Group G |
May 26 • 02:00 | Cerro Porteño | | - | | Olimpia Asunción | 0 | : | 1 |
| Group B |
May 27 • 00:00 | Club Athletico Paranaense | | - | | Caracas FC | 5 | : | 1 |
| Group B |
May 27 • 00:00 | Club Libertad | | - | | The Strongest | 4 | : | 1 |
| Group E |
May 27 • 02:00 | Boca Juniors | | - | | Deportivo Cali | 1 | : | 0 |
| Group E |
May 27 • 02:00 | Corinthians | | - | | Club Always Ready | 1 | : | 1 |
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| Jun 29 • 00:15 | CS Emelec | | - | | Atlético Mineiro | 1 | : | 1 |
| Jun 29 • 02:30 | Corinthians | | - | | Boca Juniors | 0 | : | 0 |
| Jun 29 • 02:30 | Club Athletico Paranaense | | - | | Club Libertad | 2 | : | 1 |
| Jun 30 • 00:15 | Cerro Porteño | | - | | SE Palmeiras | 0 | : | 3 |
| Jun 30 • 00:15 | Talleres de Córdoba | | - | | Colón de Santa Fe | 1 | : | 1 |
| Jun 30 • 02:30 | Vélez Sársfield | | - | | River Plate | 1 | : | 0 |
| Jun 30 • 02:30 | Deportes Tolima | | - | | Flamengo | 0 | : | 1 |
| Jul 01 • 02:30 | Fortaleza EC | | - | | Estudiantes de La Plata | 1 | : | 1 |
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| Jul 06 • 00:15 | Atlético Mineiro | | - | | CS Emelec | 1 | : | 0 |
| Jul 06 • 02:30 | Boca Juniors | | - | | Corinthians | 0 | : | 0 |
| Jul 06 • 02:30 | Club Libertad | | - | | Club Athletico Paranaense | 1 | : | 1 |
| Jul 07 • 00:15 | SE Palmeiras | | - | | Cerro Porteño | 5 | : | 0 |
| Jul 07 • 00:15 | Colón de Santa Fe | | - | | Talleres de Córdoba | 0 | : | 2 |
| Jul 07 • 02:30 | River Plate | | - | | Vélez Sársfield | 0 | : | 0 |
| Jul 07 • 02:30 | Flamengo | | - | | Deportes Tolima | 7 | : | 1 |
| Jul 08 • 02:30 | Estudiantes de La Plata | | - | | Fortaleza EC | 3 | : | 0 |
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| Aug 03 • 02:30 | Corinthians | | - | | Flamengo | 0 | : | 2 |
| Aug 04 • 02:30 | Atlético Mineiro | | - | | SE Palmeiras | 2 | : | 2 |
| Aug 04 • 02:30 | Vélez Sársfield | | - | | Talleres de Córdoba | 3 | : | 2 |
| Aug 05 • 02:30 | Club Athletico Paranaense | | - | | Estudiantes de La Plata | 0 | : | 0 |
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| Aug 10 • 02:30 | Flamengo | | - | | Corinthians | 1 | : | 0 |
| Aug 11 • 02:30 | SE Palmeiras | | - | | Atlético Mineiro | 0 | : | 0 |
| Aug 11 • 02:30 | Talleres de Córdoba | | - | | Vélez Sársfield | 0 | : | 1 |
| Aug 12 • 02:30 | Estudiantes de La Plata | | - | | Club Athletico Paranaense | 0 | : | 1 |
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| Aug 31 • 02:30 | Club Athletico Paranaense | | - | | SE Palmeiras | 1 | : | 0 |
| Sep 01 • 02:30 | Vélez Sársfield | | - | | Flamengo | 0 | : | 4 |
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| Sep 07 • 02:30 | SE Palmeiras | | - | | Club Athletico Paranaense | 2 | : | 2 |
| Sep 08 • 02:30 | Flamengo | | - | | Vélez Sársfield | 2 | : | 1 |
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| Oct 29 • 22:00 | Flamengo | | - | | Club Athletico Paranaense | 1 | : | 0 |
