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| Pool A |
Oct 13 • 20:45 | Ulster Rugby |  | - |  | Wasps RFC | 19 | : | 9 |
| Pool C |
Oct 14 • 14:00 | Leinster Rugby |  | - |  | Montpellier Hérault Rugby | 24 | : | 17 |
| Pool D |
Oct 14 • 16:15 | Racing 92 |  | - |  | Leicester Tigers | 22 | : | 18 |
| Pool A |
Oct 14 • 18:30 | Harlequins |  | - |  | Stade Rochelais | 27 | : | 34 |
| Pool E |
Oct 14 • 18:30 | Bath Rugby |  | - |  | Benetton Treviso | 23 | : | 0 |
| Pool C |
Oct 14 • 20:45 | Exeter Chiefs |  | - |  | Glasgow Warriors | 25 | : | 15 |
| Pool D |
Oct 15 • 14:00 | Castres Olympique |  | - |  | Munster Rugby | 17 | : | 17 |
| Pool E |
Oct 15 • 16:15 | RC Toulonnais |  | - |  | Scarlets | 21 | : | 20 |
| Pool B |
Oct 15 • 18:30 | Northampton Saints |  | - |  | Saracens | 13 | : | 57 |
| Pool B |
Oct 15 • 18:30 | Ospreys |  | - |  | ASM Clermont Auvergne | 21 | : | 26 |
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| Pool E |
Oct 20 • 20:45 | Scarlets | | - | | Bath Rugby | 13 | : | 18 |
| Pool C |
Oct 21 • 14:00 | Glasgow Warriors | | - | | Leinster Rugby | 18 | : | 34 |
| Pool B |
Oct 21 • 16:15 | ASM Clermont Auvergne | | - | | Northampton Saints | 24 | : | 7 |
| Pool E |
Oct 21 • 16:15 | Benetton Treviso | | - | | RC Toulonnais | 29 | : | 30 |
| Pool D |
Oct 21 • 18:30 | Leicester Tigers | | - | | Castres Olympique | 54 | : | 29 |
| Pool D |
Oct 21 • 18:30 | Munster Rugby | | - | | Racing 92 | 14 | : | 7 |
| Pool B |
Oct 21 • 20:45 | Saracens | | - | | Ospreys | 36 | : | 34 |
| Pool C |
Oct 22 • 14:00 | Montpellier Hérault Rugby | | - | | Exeter Chiefs | 24 | : | 27 |
| Pool A |
Oct 22 • 16:15 | Stade Rochelais | | - | | Ulster Rugby | 41 | : | 17 |
| Pool A |
Oct 22 • 18:30 | Wasps RFC | | - | | Harlequins | 41 | : | 10 |
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| Pool C |
Dec 08 • 20:45 | Glasgow Warriors | | - | | Montpellier Hérault Rugby | 22 | : | 29 |
| Pool E |
Dec 09 • 14:00 | Scarlets | | - | | Benetton Treviso | 33 | : | 28 |
| Pool E |
Dec 09 • 16:15 | RC Toulonnais | | - | | Bath Rugby | 24 | : | 20 |
| Pool B |
Dec 09 • 18:30 | Northampton Saints | | - | | Ospreys | 32 | : | 43 |
| Pool D |
Dec 09 • 18:30 | Castres Olympique | | - | | Racing 92 | 16 | : | 13 |
| Pool D |
Dec 09 • 20:45 | Munster Rugby | | - | | Leicester Tigers | 33 | : | 10 |
| Pool A |
Dec 10 • 14:00 | Harlequins | | - | | Ulster Rugby | 5 | : | 17 |
| Pool A |
Dec 10 • 14:00 | Stade Rochelais | | - | | Wasps RFC | 49 | : | 29 |
| Pool C |
Dec 10 • 18:30 | Exeter Chiefs | | - | | Leinster Rugby | 8 | : | 18 |
| Pool B |
Dec 11 • 18:30 | Saracens | | - | | ASM Clermont Auvergne | 14 | : | 46 |
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| Pool A |
Dec 15 • 20:45 | Ulster Rugby | | - | | Harlequins | 52 | : | 24 |
| Pool C |
Dec 16 • 14:00 | Montpellier Hérault Rugby | | - | | Glasgow Warriors | 36 | : | 26 |
| Pool E |
Dec 16 • 14:00 | Benetton Treviso | | - | | Scarlets | 12 | : | 31 |
| Pool C |
Dec 16 • 16:15 | Leinster Rugby | | - | | Exeter Chiefs | 22 | : | 17 |
| Pool D |
Dec 16 • 16:15 | Racing 92 | | - | | Castres Olympique | 29 | : | 7 |
| Pool E |
Dec 16 • 18:30 | Bath Rugby | | - | | RC Toulonnais | 26 | : | 21 |
| Pool A |
Dec 17 • 14:00 | Wasps RFC | | - | | Stade Rochelais | 21 | : | 3 |
| Pool B |
Dec 17 • 16:15 | ASM Clermont Auvergne | | - | | Saracens | 24 | : | 21 |
| Pool B |
Dec 17 • 16:15 | Ospreys | | - | | Northampton Saints | 32 | : | 15 |
| Pool D |
Dec 17 • 18:30 | Leicester Tigers | | - | | Munster Rugby | 16 | : | 25 |
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| Pool E |
Jan 12 • 20:45 | Bath Rugby | | - | | Scarlets | 17 | : | 35 |
| Pool A |
Jan 13 • 14:00 | Ulster Rugby | | - | | Stade Rochelais | 20 | : | 13 |
| Pool C |
Jan 13 • 16:15 | Exeter Chiefs | | - | | Montpellier Hérault Rugby | 41 | : | 10 |
| Pool A |
Jan 13 • 18:30 | Harlequins | | - | | Wasps RFC | 33 | : | 28 |
| Pool B |
Jan 13 • 18:30 | Northampton Saints | | - | | ASM Clermont Auvergne | 34 | : | 21 |
| Pool B |
Jan 13 • 20:45 | Ospreys | | - | | Saracens | 15 | : | 15 |
| Pool C |
Jan 14 • 14:00 | Leinster Rugby | | - | | Glasgow Warriors | 55 | : | 19 |
| Pool E |
Jan 14 • 14:00 | RC Toulonnais | | - | | Benetton Treviso | 36 | : | 0 |
| Pool D |
Jan 14 • 16:15 | Racing 92 | | - | | Munster Rugby | 34 | : | 30 |
| Pool D |
Jan 14 • 18:30 | Castres Olympique | | - | | Leicester Tigers | 39 | : | 0 |
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| Pool C |
Jan 20 • 14:00 | Glasgow Warriors | | - | | Exeter Chiefs | 28 | : | 21 |
| Pool C |
Jan 20 • 14:00 | Montpellier Hérault Rugby | | - | | Leinster Rugby | 14 | : | 23 |
| Pool B |
Jan 20 • 16:15 | ASM Clermont Auvergne | | - | | Ospreys | 24 | : | 7 |
| Pool B |
Jan 20 • 16:15 | Saracens | | - | | Northampton Saints | 62 | : | 14 |
| Pool E |
Jan 20 • 18:30 | Benetton Treviso | | - | | Bath Rugby | 28 | : | 47 |
| Pool E |
Jan 20 • 18:30 | Scarlets | | - | | RC Toulonnais | 30 | : | 27 |
| Pool D |
Jan 21 • 14:00 | Leicester Tigers | | - | | Racing 92 | 20 | : | 23 |
| Pool D |
Jan 21 • 14:00 | Munster Rugby | | - | | Castres Olympique | 48 | : | 3 |
| Pool A |
Jan 21 • 16:15 | Stade Rochelais | | - | | Harlequins | 16 | : | 7 |
| Pool A |
Jan 21 • 16:15 | Wasps RFC | | - | | Ulster Rugby | 26 | : | 7 |
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| Mar 30 • 18:30 | Scarlets | | - | | Stade Rochelais | 29 | : | 17 |
| Mar 31 • 16:15 | Munster Rugby | | - | | RC Toulonnais | 20 | : | 19 |
| Apr 01 • 14:00 | ASM Clermont Auvergne | | - | | Racing 92 | 17 | : | 28 |
| Apr 01 • 16:30 | Leinster Rugby | | - | | Saracens | 30 | : | 19 |
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| Apr 21 • 16:30 | Leinster Rugby | | - | | Scarlets | 38 | : | 16 |
| Apr 22 • 16:15 | Racing 92 | | - | | Munster Rugby | 27 | : | 22 |
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| May 12 • 17:45 | Leinster Rugby | | - | | Racing 92 | 15 | : | 12 |
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